فهرست مطالب sara beigrezaei

Several studies assessed the relationship between the cholesterol ester transfer protein (CETP) Taq1B gene polymorphism (rs708272) with risk factors of cardiovascular diseases (CVDs). However, their findings were inconsistent. The present study investigated the relationship between CVD risk factors and the Taq1B variant in patients undergoing coronary angiography.  This cross-sectional study was conducted on 476 patients aged 30-76 years old of both sexes from 2020-2021, in Yazd (Iran). The Taq1B polymorphism genotypes were evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on DNA extracted from whole blood. Standard protocols were used to measure cardio-metabolic markers. To determine the association between CVDs risk factors and the rs708272 variant, binary logistic regression was used in crude and adjusted models. Taq1B polymorphism genotype frequencies were 10.7% for B1B1, 72.3% for B1B2, and 17% for B2B2. There was no significant association between abnormal levels of CVDs risk factors and different genotypes of the Taq1B variant, Gensini score (P=0.64), Syntax score (P=0.79), systolic blood pressure (P=0.55), diastolic blood pressure (P=0.58), and waist circumference (P=0.79). There was no significant association between genotypes of the rs708272 variant and any abnormal serum lipid levels. After adjusting for confounders, the results remained non-significant. There was no significant association between CVDs risk factors and CETP rs708272 polymorphism. The relationship between CETP gene variants and CVD occurrences varied across groups, implying that more research in different regions is required. A preprint version of this manuscript is available at https://www.researchsquare.com/article/rs-2575215/v1 with doi: 10.21203/rs.3.rs-2575215/v1.

Although several studies have attempted to identify coronary artery disease (CAD) risk factors, few have explored the association between lifestyle-related factors and the severity of coronary artery stenosis. The present study was designed to assess the association between a combination of lifestyle, dietary, cardiometabolic, psychological, and mental factors, and CAD severity in adults undergoing angiography. This cross-sectional study aimed to recruit a total of 700 patients (aged 35 to 75 years) who met the inclusion criteria and were referred for angiography between July 2020 and November 2021 to Afshar Hospital, a central heart disease hospital in Yazd city, Iran. To assess the presence and intensity of CAD, we used the Gensini and SYNTAX scores. Biochemical factors were measured using standard kits from serum samples, and extra serum and whole blood samples were retained for further analyses. Data on general information, dietary food and supplement intake, eating habits, medicinal herbs consumption, psychological and mental state, sleep quality, and other variables were gathered by trained interviewers using specific questionnaires. In total, 720 participants (444 males and 276 females) aged 56.57±9.78 years were included in the current study. Moderate to severe coronary artery stenosis was prevalent in 47.0% and 17.9% of participants based on Gensini and SYNTAX scores, respectively. The results of this study will enhance our understanding of the association between different risk factors and the severity of coronary artery stenosis.

 Genetic and environmental factors are involved in the pathogenesis of cardiovascular diseases (CVDs). The aim of the study was to investigate between the genotype of the NFKB1 gene and the cardiometabolic risk factor in patients undergoing coronary angiography.

 This cross-sectional study was conducted on 462 adults (male and women) aged between 35 and 75 years who referred to Afshar Hospital for coronary angiography in 2021- 2022. The polymerase chain reaction restriction fragment length polymorphism method was used to detect the genotype of rs28362491. Biochemical parameters were measured using commercial kits. Gensini and Syntax scores were calculated using the angiography result to assess the extent of coronary artery stenosis. We used multivariate logistic regression analysis to examine the relationship between genotype variants and cardiometabolic risk factors.

 There was no association between variant genotypes and abnormally levels of serum alanine aminotransferase (ALT) (P value=0.51), aspartate aminotransferase (AST) (P value=0.99), triglyceride (TG) (P value=0.48), total cholesterol (P value=0.79), low density lipoprotein-cholestero (LDL-C) (P value=0.31), high-density lipoprotein-cholesterol (HDL-C) (P value=0.53), fast blood sugar (FBS) (P value=0.39), systolic blood pressure (P value=0.14), diastolic blood pressure (P value=0.64), Gensini score (P value=0.48) and syntax score (P value=0.74) in the crude model even after adjustment for confounding factors.

 We found no association between the ATTG polymorphism and cardiometabolic risk factors in patients who had coronary angiography. Further investigations are needed to assess the association between variants of 28362491 and cardiometabolic markers.

It is suggested that palm oil consumption might increase the likelihood of developing chronic diseases including cardiovascular disease. Previous studies that investigated the effect of palm oil intake on anthropometric measures, blood glucose control, inflammation, and oxidative stress markers were inconclusive. This is while previous systematic review and meta-analyses should be updated.

The present study describes a protocol for a range of systematic reviews and meta-analyses to examine the effect of palm oil intake on body weight and fat, inflammatory markers, oxidative stress, liver enzymes, blood pressure, and blood glucose control indices.

ISI web of science, EMBASE, MEDLINE, Scopus, and Google Scholar will be searched using medical subject heading (MeSH) and non-MeSH keywords. Controlled clinical trials will be selected based on predefined eligibility criteria. The intra-study risk of bias will be checked by using the Cochrane collaboration's tool. Mean difference (MD) (the difference between mean change values in the intervention group/period and control group/period) and its corresponding standard deviation will be calculated to be used as effect size. A random-effects meta-analysis will be performed to pool the results. Subgroup analysis and meta-regression will be conducted to explore the possible sources of heterogeneity. Sensitivity analysis will be conducted by removing the studies one-by-one from the overall analyses. Publication bias will be assessed by inspecting funnel plots and using asymmetry tests.

The results of systematic reviews and meta-analyses might provide helpful data about the effects of palm oil consumption on different aspects of health among adults. The evidence provided by the results of systematic reviews can be useful for dietitians, clinicians, public health policy-makers, and the public.

Increasing rate of type 2 diabetes (T2D) prevalence during the recent years has caused concern about significant risks for the public health. Dietary patterns have recently attracted great attention in the evaluation of the relationship between diet and health. In the present study, we investigated the relationship between the major identified dietary patterns and T2D.

In this matched case–control study, 315 individuals (125 newly diagnosed cases and 190 controls); 18–60 years of age were selected. A valid semiquantitative food frequency questionnaire was used to collect dietary intakes of individuals. Anthropometric characteristics and blood pressure were measured with standard instructions and body mass index and waist to hip ratio were calculated. Factor analysis was used to identify major dietary patterns. The relationship between major food patterns and T2D was assessed by logistic regression analysis.

Two dietary patterns were identified: healthy and Western dietary patterns. The second tertile of the healthy dietary pattern had significantly association with decreased risk of T2D in the crude model (Odds ratios [OR]: 0.51, 95% Confidence interval [CI]: 0.29–0.9; P for trend = 0.018), Model II (OR: 0.5, 95% CI: 0.27–0.9; P for trend = 0.019), and Model III (OR: 0.56, 95% CI: 0.23–1.4 P for trend = 0.048). The inverse association of the second tertile of Western dietary pattern score with the T2D was significant in crude (OR: 9.25, 95% CI: 4.95– 17.4; P for trend <0.001) and multivariable‑adjusted model (OR: 16.65, 95% CI: 2.99–92.84; P for trend <0001).

Our study found an inverse relationship between adherence of healthy pattern and direct association with Western dietary pattern and the risk of T2D.

Population studies have demonstrated that there is an inverse association between dietary intake of vitamin D and the mean blood pressure in elderly in particular. So, we investigated the correlation between vitamin D intake and the mean blood pressure in the elderly with and without nursing care. Based on a cross‑sectional design, this study was conducted on 152 old people with and without nursing care. Assessment of the dietary intake of nutrients was done by an expert dietitian using food frequency questionnaire and nutritionist IV software analyzer. Also, the mean blood pressure was extracted from participants’ fles. The independent samplet‑test, Chi‑square test, and partial correlation test were used for data analysis. Mean ± SD age, weight, height, body mass index (BMI) of participants, and the percentage of male/females were 68.7 ± 5.5 years, 63.5 ± 7.9 kg, 162.5 ± 7.1 cm, 24.1 ± 3.4 kg/m2 and 48.7/51.3, respectively. Also, a signifcant negative relationship was observed between vitamin D intake and systolic blood pressure in all participants (P value = 0.028, r = -0.179). There was no signifcant correlation between vitamin D intake and diastolic blood pressure (P value = 0.558, r = -0.048). The fndings revealed that the nursing care can improve dietary intake of vitamin D in the elderly population. Also, a negative correlation was found between vitamin D intake and systolic blood pressure among all the elderly.

Chronic kidney disease (CKD) is a consequence of progressive and irreversible destruction of nephrons, mainly due to uncontrolled diabetes mellitus and high blood pressure. Ghrelin is a peptide hormone which could play a substantial role in hunger sensation, may increase body fat percentage and might adjust the long-term body weight and is mostly secreted in the stomach.
This study aimed to evaluate the relationship between ghrelin levels and various biochemical and demographic indices in a group of non-diabetic hemodialysis patients.
Patients and Around 39 non-diabetic patients undergoing hemodialysis in Hajar hospital at Shahrekord city were enrolled. The mean age of patients was 57.10±20.20 years. Their mean weight was 56.65 ±16.25 kg. Their hemoglobin level mean was 10.43±1.84 g/dL. The serum ghrelin level had a positive but not significant correlation with the age, dialysis quality, dosage, calcium level, alkaline phosphatase (ALP), parathormone, vitamin D and hemoglobin in these patients.
More studies in this subject of hemodialysis patients to define the exact role of ghrelin in hemodialysis patients are recommended.

Chronic kidney disease (CKD) is a serious universal problem that is the main risk for several diseases including cardiovascular disease. Dietary factors are important to prevent and control the kidney disease. Some evidence has shown that modifying the amount and the types of dietary protein exert a major effect on renal failure so limiting dietary protein and substituting animal protein with soy protein has suggested. However, there is a lot of controversy about it, especially in human. Thus, this paper will review the clinical trial studies conducted on the effects of soy protein intake on CKD in both animal and human and its effect mechanism.

Medicinal plants have special importance around the world. Further, they have been noticed for nutrition and illness treatment such as preparation of anticancer new drugs. Therefore, a wide range of studies have been done on different plants, and their anticancer effects have been investigated. Nowadays, cancer is the most important factor of death rate in the developed and developing countries. Among them, stomach cancer is one of the most common malignancies around the world. At present, it is recognized as the fourth common cancer and the second factor of death rate due to cancer. So far, there has been wide range of effort for cancer treatment; however, in most cases, the response to the treatment has been very weak and often accompanied improper subsidiary effects.
The present problems as a consequence of chemical treatment and radiotherapy and many subsidiary problems created due to their use for patients, and also, the resistance to the current treatment has motivated researchers to apply new medicines with more effect and less toxicity. The secondary metabolisms existent in the plants have an important role in the treatment of several diseases such as cancer. This study was conducted to investigate and collect scientifc results for stomach cancer and to clarify the role of medicinal plants and secondary plant compounds on its treatment.

Adiponectin is a cytokine produced by the adipose tissue. This collagen-like protein has 244-amino acid and its concentration in plasma of healthy individuals is 5-40 μg / mL. In fact, adiponectin comprises 1% of the total serum protein. Although, adiponectin has anti-inflammatory and anti-atherogenic effects in physiological conditions and plays a key role in lipid and glucose metabolism and energy balance as well. However, in patients with end-stage renal disease, it is not a protector due to the changes in the structure and function, and also is considered as a risk factor. So with regard to the prevalence of atherosclerosis in patients with end stage renal disease, adiponectin may be a marker for indentifying the cardiovascular involvement of these patients.

The present world is a world of short-sectional relationships, most people identify themselves by acknowledging their appearance instead of considering their inherited or acquired different characteristics. In this study, we decided to compare the body image between patients with skin diseases and healthy participants.
In this case-control study, 300 (150 cases and 150 controls) individuals aged from 18 to 64 years were selected in the Isfahan city. Satisfaction with body image and feelings of respondents regarding their apparent looks in different situations and different conditions were investigated using an a researcher-constructed questionnaire. To analyze the collected data, we used the analysis of covariance and compared the means.
Single, younger, and less educated women had body image scores higher and more positive look to their bodies. Healthy people had higher score of body image than the patients with skin diseases. There was no significant relationship between gender and body image scores.
Skin diseases had an important role in body image. So we suggest that the effect of other diseases, that somehow affect the appearance of people on body image, be examined deeply for each disease.