فهرست مطالب seyed hadi mousavi

The present work examined the anti-metastatic effects of auraptene and their underlying mechanisms of action in U87 Glioblastoma multiforme (GBM) cells. To test the hypothesis, cell culture, Matrigel invasion assay, scratch wound healing assay, gelatin zymography assay, qRT-PCR, and western blot analysis were conducted. At sublethal concentrations of 12.5 and 25 µg/ml, auraptene exhibited a significant reduction in cell invasion and migration of U87 cells, as assessed using scratch wound healing and Transwell tests, respectively. The qRT-PCR and zymography experiments demonstrated a significant decrease in both mRNA expression and activities of MMP-2 and MMP-9 following auraptene treatment. Western blot analysis also showed that the total protein level of MMP-2 as well as phosphorylation of crucial metastasis-related proteins, including p-JNK and p-mTOR, decreased in auraptene-treated cells. The molecular docking studies consistently demonstrated that auraptene exhibits a significant affinity towards MMP-2/-9, the ATP binding site of mTOR and JNK1/2/3. Auraptene effectively inhibited the migration and invasion of GBM cells. This inhibitory effect was induced by modulating specific mechanisms, including suppressing MMPs, JNK, and mTOR activities. Auraptene might serve as a potential anti-metastatic agent against malignant GBM.

One of the very key concepts in the definition of modern Islamic civilization is the concept of "spirituality". In this article, our main problem is to investigate the intrinsic and essential components of spirituality in the modern Islamic civilization and the abundance of spirituality in the modern civilization and the guiding place of spirituality in this civilization from the perspective of Ayatollah Khamenei's thoughts. Our purpose in this research is to provide a deep understanding of the concept of Islamic spirituality and to assess the aspects of the influence of spirituality in the foundation, evolution and progress and realization of the new Islamic civilization in the thought of Ayatollah Khamenei.  

In this article, the analytical descriptive method is used, relying on library sources. In the analytical descriptive method, first of all, the issues and topics of the article are tried from the perspective of Ayatollah Khamenei by following and studying throughout his works and statements, focusing on the two concepts of "spirituality" and "new Islamic civilization" with three characteristics of conceptual system, deep description and systematic view. , be explained, and in the next step, based on deep and clear explanations and descriptions of the research subjects, we will analyze their different aspects, layers and levels in a logical, chain-wise, systematic and ijtihad way.

1. From the point of view of Ayatollah Khamenei, Islamic spirituality in such a way that the type of spirituality includes faith and knowledge of the unseen, obedience and actions based on the Sharia, and finally being adorned with moral virtues. In other words, the subject of Islamic spirituality, "spiritual intellect", " "spiritual soul" and "spiritual verb".A brief summary of the concept of new Islamic civilization being full of spirituality from Ayatollah Khamenei's point of view is that according to what forms the interior of Islamic spirituality, new civilization is a spiritual and divine civilization that is full of collective spiritual rationality, which is a sign of its expansion. Belief in the unseen and worldview is clear, full of meaning and divine, and the prominent feature of this faith is awareness, commitment, responsibility, and continuous reproduction. In the context of this spiritual rationality and the commitment and fertility of everyone's faith, humans become possessed of a spiritual soul and soul, the obvious effect of which is the existence and abundance and predominance of moral virtues in the modern Islamic civilization, and the scarcity, weakness, and lack of governance of vices, impurities, and rebellions.The first aspect of the role of Islamic spirituality in shaping the new Islamic civilization is the foundational and infrastructure-building aspect, in the sense that Muslims can once again realize great ideals such as the new Islamic civilization. And make their actions real in their intellect, soul and action.Another effective aspect of spirituality for Islamic civilization is that spirituality, just as it is a source of soul, purpose and identity for humans, it also gives meaning, identity and purpose to society and modern civilization.Another aspect of spirituality guidance for the modern Islamic civilization is mainly due to the spiritual view and knowledge of the world and man, and it provides the theoretical and worldview infrastructure of the modern Islamic civilization.The other aspect of guiding spirituality for the new Islamic civilization is to ensure the inner endurance of man and to fight against the internal factors that weaken this endurance inside and outside of man in order to realize the new Islamic civilization as well as its effective survival and continuity.Another effect of Islamic spirituality in modern Islamic civilization is that it prevents believers from being influenced by enemies' obsessions and following sensual desires as the causes of weakening perseverance in the direct path of Islamic civilization and deviation from it.

According to Ayatollah Khamenei, Islamic spirituality is faith in the unseen, the inner purity of man in the light of the unseen, and submission and servitude to the unseen. The concept of modern Islamic civilization being full of spirituality also refers to the existence of conscious faith and the rule of virtues and the centrality of divine worship throughout modern Islamic civilization. The effective and guiding aspects of Islamic spirituality for the new Islamic civilization are the six aspects of grounding, identity-building, knowledge-giving, strength and endurance-giving, immunity-building and speeding-up of the new Islamic civilization. Islamic spirituality covers the modern Islamic civilization from the beginning to the end: it provides the ground for the formation of the modern civilization, gives it identity and identity, provides its basic knowledge, strengthens its foundations and existence, protects it against degeneration and It prevents stagnation and stagnation and gives speed and ease to its movement to reach its goals.

 Acute myeloid leukemia (AML) has a complex course of treatment, including chemotherapy and bone marrow transplantation, which mostly results in drug resistance and recurrence. Therefore, alternative therapies have attracted the attention of researchers. Mesenchymal stem cells exert their paracrine effects through the secretion of multiple cytokines and vesicles. Recent findings suggest the possible antitumor properties of MSCs by the secretion of micro-vesicles, and consequent activation of cell death pathways in cancer cells. The present study evaluated how micro-vesicles from human placental mesenchymal stem cells affect the autophagy and apoptosis pathways in AML.

 After isolation and culture, hPMSCs were identified through flow cytometry. The Bradford method was employed to determine the concentration of MVs. The properties of MVs were confirmed by transmission electron microscopy (TEM) and DLS. Next, the KG1 cell line was exposed to MVs at concentrations of 25, 50, and 100 μg/ml for 24 hours. Subsequently, apoptosis was assessed using an Annexin V-FITC/PI kit, and ROS activity was gauged through the utilization of H2DCFDA. The gene expression in the autophagy and apoptosis pathways was investigated by using the real-time PCR technique.

 After 24 hours of treatment, a rise in intracellular ROS accumulation and apoptosis was observed in all groups compared to the control group. The mean intracellular ROS accumulation at the concentrations of 25, 50, and 100 μg / ml of the samples and the control group was 62.21% (P<0.0002), 66.25% (P<0.0001), 62.55% (P<0.0001), and 26.1% (P<0.0001), respectively. The apoptosis indices at the concentrations of 25, 50, and 100 μg / ml of the samples were 62.6% (P<0.0002), 46.0% (P<0.0001), and 48.2% (P<0.0001), respectively. Furthermore, analyzing genes through RT-PCR indicated a considerable increase in the expression of autophagy-related and pro-apoptotic genes.

 Our findings indicate that hPMSC-MVs induce Cell death pathways of autophagy and apoptosis in the KG1 cell lines. Additionally, hPMSC-MVs exhibited heightened impactful anti-proliferative and pro-apoptotic outcomes on KG1 cells in vitro.

β-Thalassemia is one of the most common groups of hereditary hemoglobinopathies. This study aimed to investigate the concentrations of hepcidin, ferritin, some interleukins (IL-6 and IL-10), and some hormones (Testosterone and follicle-stimulating hormone [FSH]) in β-thalassemia patients compared to healthy people.

This study was conducted on 150 male subjects. Individuals were randomly assigned to either case group (β-thalassemia patients, n=100) or control group (healthy, n=50) based on simple randomization from Azadi Teaching Hospital and Al-Jumhuri Hospital in Iraq, from April 2022 to July 2022. Experimental work was carried out at laboratories in Kirkuk, Iraq.

Our findings showed that the hepcidin and ferritin concentrations had a significant increase in the case group (P<0.05) compared to the control group. IL-6 and IL-10 concentrations demonstrated a significant rise in patients (P<0.05) compared to the control group. The concentration of sexual hormones (Testosterone and FSH) demonstrated a significant reduction in the case group (P<0.05) compared to the control group.

β-thalassemia, in addition to hematological abnormalities, is caused by mutations in the beta gene. It is involved with other problems, such as immune, inflammatory, and endocrine imbalances. Evaluating and monitoring the biochemical, hormonal, and inflammatory factors mentioned in the present study can help prevent the iron-overload-induced consequences of major β-thalassemia.

The purpose of the study, with a descriptive-analytical method based on library documents, lies in explaining and proving the concept of two components of Ayatollah Khamenei`s theology including: "establishment of religion" and "rule of religion" as two parts of Islamic religion. The findings of the research show that "establishing religion", that is, practicing it in all aspects of life, is one of the components of Islam. The sum of "sciences and rules" and their "external realization" form the religion of Islam, and Islam insists on establishing all the components of the religion and is not satisfied with the realization of some parts of them. "Sovereignty of religion" is also one of the components of Islam. Islam has both "jurisdictional general sovereignty" which means the inclusion of its systematic rulings on all aspects of human life, and it also has "objective general sovereignty" over society, which is manifested in the social political sovereignty of Islam

Microvesicles have been identified as candidate biomarkers for treating AML. This study investigated the effects of hUCMSC-derived MVs on apoptosis and autophagy in the KG-1 leukemic cell line.

The hUCMSCs were cultured and characterized by flow cytometry. MVs were isolated by ultracentrifugation was determined using the Bradford method. The characteristics of MVs were confirme4d using TEM, flow cytometry, and DLS methods. KG-1 cells were treated with the desired concentrations of MVs for 24 h. The apoptosis induction and ROS production were evaluated using flow cytometry. RT-PCR was performed to evaluate apoptosis- and autophagy-related genes expression.

Following tretment of KG-1 cells with 25, 50, and 100 μg/ml concentrations of MVs, the apoptosis rates were 47.85%, 47.15%, and 51.35% (p < 0.0001), and the autophagy-induced ROS levels were 73.9% (p < 0.0002), 84.8% (p < 0.0001), and 85.4% p < 0.0001, respectively. BAX and ATG7 gene expression increased significantly at all concentrations compared to the control, and this level was higher at 50 μg/ml than that of the other concentrations. In addition, LC3 and Beclin 1 expression increased significantly in a concentration-dependen manner. Conversely, BCL2 expression decreased compared to the control.

Our findings indicate that hUCMSC-MVs could induce cell death pathways of autophagy and apoptosis in the KG-1 cell lines and exert potent antiproliferative and proapoptotic effects on KG-1 cells in vitro. Therefore, hUCMSC-MVs may be a potential approach for cancer therapy as a novel cell-to-cell communication strategy.

Psoriasis is a chronic inflammatory autoimmune disease. The effectiveness of noscapine has been employed as a helpful treatment for various disorders and subjected to recent theoretical breakthroughs. Psoriasis-like lesions were induced by topical application of 5% imiquimod (IMQ) (10 mg/cm2 of skin) in male Balb/c mice and then medicated with a single oral dose of methotrexate (MET) as a positive control or daily oral treatment of noscapine (5, 15 and 45 mg/kg). In this way, skin inflammation intensity, psoriatic itchiness, psoriasis area severity index (PASI) score, ear length, thickness, and organ weight were daily measured. At the end of the study, histological and immunohistochemical and enzyme-linked immunosorbent assays (ELISA, for pro-/anti-inflammatory factors) were performed in each ear. IMQ caused psoriasis-like lesions. Noscapine markedly alleviated macroscopic parameters, namely ear thickness, ear length, skin inflammation, itching, and organ weight, as well as microscopic parameters including, pathology and Ki67 and p53, and tissue immunological mediators, such as tumour necrosis factor (TNF-α), interleukin (IL)-10, transforming growth factor (TGF-β), interferon-g (IFN-g), IL-6, IL-17, and IL-23p19 in the psoriatic skin in a concentration manner (p<0.05-<0.001). Therefore, noscapine with good pharmacological properties has considerable effects on psoriasis inflammation.

Neobaicalein is one of the rich plant flavonoids isolated from the roots of Scutellaria spp. In this study, we evaluated and compared cytotoxic activity and the related apoptosis mechanisms of neobaicalein from Scutellaria litwinowii Bornm. & Sint. ex Bornm on apoptosis-proficient HL-60 cells and apoptosis-resistant K562 cells. 

Cell viability, cell apoptosis, caspase activity, and apoptosis-related protein expression were measured using MTS assay, propidium iodide (PI) staining and flow cytometry, caspase activity assay, and western blot analysis, respectively. 

Neobaicalein significantly reduced cell viability in a dose-dependent manner using the MTS assay (P<0.05). The IC50 values (µM) against HL-60 and K562 cells after 48 hr treatment were 40.5 and 84.8, respectively. Incubation of HL-60 and K562 cells with 25, 50, and 100 µM neobaicalein for 48 hr, significantly increased the number of apoptotic cells and showed cytotoxic effects compared with the control group. Treatment with neobaicalein significantly increased Fas (P<0.05) and the cleaved form of PARP (P<0.05), and decreased the Bcl-2 levels (P<0.05) in HL-60 cells, whereas neobaicalein significantly increased Bax (P<0.05) and the cleaved form of PARP (P<0.05), and the caspases of the extrinsic and intrinsic pathways including caspases-8 (P<0.0001), -9 (P<0.01), and effector caspase-3 (P<0.0001) levels in K562 cells compared with the control group.

It seems neobaicalein might cause cytotoxicity and cell apoptosis through interaction with the different apoptosis-related proteins of apoptotic pathways in HL-60 and K562 cells. Neobaicalein may exert a beneficial protective effect in slowing the progression of hematological malignancies.

Ferula gummosa (F. gummosa), a potent medicinal herb, has been shown to possess anticancer activities in vitro. The present examination evaluated the cytotoxic and apoptogenic impacts of F. gummosa gum on the U87 glioblastoma cells.

 MTT assay to determine the cell viability, flow cytometry by annexin V/FITC-PI to apoptosis evaluation, reactive oxygen species (ROS) assay, and quantitative RT-PCR were performed.

The results revealed that F. gummosa inhibited the growth of U87 cells in a concentration- and time-dependent manner with IC50 values of 115, 82, and 52 μg/mL obtained for 24, 48, and 72 h post- treatment, respectively. It was also identified that ROS levels significantly decreased following 4, 12, and 24 h after treatment. The outcomes of flow cytometry analysis suggested that F. gummosa induced a sub-G1 peak which translated to apoptosis in a concentration-dependent manner. Further examination revealed that F. gummosa upregulated Bax/Bcl-2 ratio and p53 genes at mRNA levels.

 Collectively, these findings indicate that sub-G1 apoptosis and its related genes may participate in the cytotoxicity of F. gummosa gum in U87 cells

Education is the vital and economic engine of any society that changed from traditional to electronic mode following the Covid-19 epidemic and provided the necessary context for self-teaching thinking. In the field of education, there is a concept called self-directed learning, which consists of three separate parts: self means personal, directed means guidance and learning means learning. In fact, self- directed learning includes all cognitive and motivational processes which the learner determines goals accordingly and plans in that direction.

 This research is a narrative review study of some articles and books published in the field of self- directed learning from 1975 to 2020.

 To achieve self- direction in learning, it is necessary to strengthen skills and characteristics. In fact, both learner and teacher have roles that the learner can contribute to the effectiveness of their learning.

One of the effective ways to be self- directed in learning, motivation and commitment. In fact, self- directed learning will be effective when the person first feels the need to learn, then determines goals for successful learning, and finally, to achieve the goals from communication tools, participation and teacher monitoring get help.

Acute myeloid leukemia (AML) is characterized by abnormalities of differentiation and growth of primary hematopoietic stem cells (HSCs) in the blood and bone marrow. In many studies, miR-625-5p has been shown to inhibit downstream pathways from affecting the metastasis and invasion of the integrin-linked kinase (ILK) signaling pathway. It has been proved that the expression of miR-625-5p decreases in AML cell lines. This study aimed to investigate the effect of miR-625-5p upregulation on the invasion of KG1 ell line in vitro.

Materials And Methods:

In this experimental study, we investigated the impact of upregulation of miR-625-5p on ninvasion via the ILK/AKT pathway in the KG1 cell line. After transfection using the viral method, the cellular invasion was assessed by invasion assay and the levels of miR-625-5p genes and protein were evaluated by quantitative polymerase chain reaction (qPCR) and western blotting. Moreover, CXCR4 level was assessed by flow cytometry.

The invasion significantly reduced in MiR-625-5p-transfected KG1 cells (P<0.01) that was concomitant with remarkably decreasing in the expression levels of ILK, NF-κB, and COX2 genes compare with the control group (P<0.01). Incontrast, MMP9, AP1, and AKT significantly increased (P<0.01, P<0.001 and P<0.01, respectively) and GSK3β did not change significantly in MiR-625-5p-transfected KG1 cells. The protein level of NF-κB decreased (P<0.01) and MMP9 increased, however it was not significant. Moreoever, the expression of CXCR4 was significantly lower (P<0.01) in comparison with the control group.

miR-625-5p leads to a reduction in cell invasion in the AML cell line through ILK pathway. Therefore, it could be a breakthrough in future AML-related research. However, further studies are needed to support this argument.

The SARS-CoV-2 virus is a member of the coronavirus family that caused the COVID-19 respiratory disease epidemic in China before the global pandemic of the disease in late 2019. The virus's genome is of 79% similarity to that of the SARS-CoV virus, using the ACE2 receptor to enter its target cells. The most common symptoms of this disease include fever, cough, pulmonary involvement, and sometimes gastrointestinal symptoms. A decline in both the number and function of lymphocytes and a severe increase in leukocyte inflammatory activity are among the most obvious immunological complications of this disease. If the immune system response to the virus is inadequate, the disease can become acute. Immune cells activity leads to a sharp increase in the number of blood cytokines, causing "cytokine storm," which in turn can cause systematic damages to the heart, lungs, and kidneys, and ultimately may lead to death. Mesenchymal stem cell therapy offers a promising approach to reducing the destructive impacts of infection in patients with COVID-19. Mesenchymal stem cells can secrete immune-modulating factors that suppress cytokine storms. Furthermore, the role of mesenchymal stem cells in preventing cell death and inhibiting tissue fibrosis has been well demonstrated. This review shows available clinical trials that have tapped into the therapeutic potential of the umbilical cord mesenchymal stem cells in patients with COVID-19.

Acute lymphoblastic leukemia (ALL) is a malignant disease of lymphoid progenitor cells affecting both children and adults. Long non-coding RNAs (lncRNAs) are one kind of non-coding RNAs (ncRNAs), reported modulatingthe initiation or progression of diversecancers. However, the role of CCDC26 and FOXCUT long non-coding RNAs in ALL has been unknown.In this study, we explored the expression of FOXCUT and CCDC26 lncRNAs in acute lymphoblastic leukemia cell lines.

Acute T lymphoblastic leukemia cell lines, RPMI 8402, Jurkat, B lymphoblastic leukemia, Daudi,and Ramoscell lines were used.After culturing the cells, RNA extraction and cDNA synthesiswere performed.The real-time PCR technique was then used to study the expression of CCDC26, FOXCUT, C-kit, and FOXC1 genes.

We found a significant increase of CCDC26 expression in RPMI 8402 (p<0.0001) and Ramos (p<0.05)cell lines compared to the control, while decreased expression of thesegeneswas observed in Jurkat and Daudi cell lines. Furthermore, FOXCUT gene had a significant increase in expression in all cell lines compared to the control (p<0.01 in Daudi and RPMI 8402 cell lines) (p<0.001 in Jurkat and Ramos cell lines).

Our results demonstrated that CCDC26 and FOXCUT genes can play a regulatory role in acute lymphoblastic leukemia and may serve as a potential diagnostic biomarker and therapeutic target of acute lymphoblastic leukemia.

N-Acetylcysteine (NAC) is a cost-effective antioxidant and very useful treatment for several diseases.

Here we report a rare case of iatrogenic NAC overdose following the mistake in calculation of the loading dose.

The patient was 14 years old girl referred to a local hospital due to history of intentional ingesting about 7grams acetaminophen. The physician prescribed her 6 grams NAC as a loading dose but 42grams NAC were infused by mistake. After infusion, the patient showed signs of anaphylactic shock and then transferred to Imam Reza toxicology-unite with weakness, lethargy, extreme fatigue, nausea, and dizziness. NAC overdosing, in a short period of time, led to coagulopathy, reduced platelet count, acute renal failure and metabolic acidosis. After 24 h, the patient died. The Medical forensic examination showed minor lung hemorrhage and presence of little amount of Aluminum phosphide in tissues they did not find no vital organ hemorrhage. It is unclear related to NAC overdose, phosphine intoxication or synergic effects.

Massive transfusion of NAC was associated with impairment of coagulation factors, intracranial hypertension, renal failure and metabolic acidosis. Thus, NAC administration should be with caution. The medical history of patients committed suicide are not always accurate and complete evaluation are recommended

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Several experimental studies have shown neuroprotective and antioxidant effects for Artemisia absinthium. The present study was designed to assess the effect of A. absinthium on 6-hydroxydopamine (6-OHDA)-induced toxicity in SH-SY5Y cells.
SH-SY5Y cells were treated with ethanolic extract of A. absinthium for 24 hr and then, exposed to 6-OHDA (250 μM) for another 24 hr. MTT (3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyl tetrazolium bromide) assay was used for evaluation of cell viability. Moreover, the rate of apoptosis was measured using propidium iodide (PI) staining. The amount of intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) was also measured using 2’, 7’–dichlorofluorescin diacetate (DCFDA) fluorometric method. Determination of glutathione (GSH) and superoxide dismutase (SOD) activity was done by colorimetric assay using DTNB [5, 5′-Dithiobis (2-nitrobenzoic acid)] and pyrogallol respectively.
While 6-OHDA significantly increased ROS and apoptosis (p<0.001), the extract of A. absinthium significantly reduced ROS and cell apoptosis at concentrations ranging from 6.25 to 25 μg/mL (p<0.01 and p<0.001 respectively). Also, the extractsignificantly reduced MDA level in comparison with 6-OHDA (p<0.001). The GSH level and SOD activity were increased by the extract.
Findings of the current study showed that A. absinthium exerts it effect throughinhibiting oxidative stress parameters and it can be considered a promising candidate to be used in combination with the conventional medications for the treatment of neurodegenerative disorders, such as Parkinson's disease.

 Juvenile delinquents are a group of people that is in dire need of psychosocial rehabilitation. In this research, we seek to assess the lived experience in two groups of delinquent adolescents: one group is repetitive delinquents, the second group successfully returned to society. We tried to understand the relevant and essential factors in making this difference. 

 This study is a qualitative research based on Grounded Theory. In this study, samples of adolescents with recurrent crimes and samples that have successfully returned to society without recidivism were reviewed. To do this, we should have investigated each case separately and the whole process that led to the recurrence of the crime. However, because the size of the statistical population is not sufficient to use quantitative and generalized methods, a case-experienced study has been conducted. This method assesses current phenomena in their real-life context, especially when the boundaries between a phenomenon and the context in which it occurs are not clearly defined. Several sources of evidence were used. After the coding of the gathered data and the formulation of the interviews in the form of concepts, the next step was to increase the level of abstraction of these concepts and propositions in the form of subcategories.

 Finally, of 222 propositions, we reached 100 concepts that were mainly associated with recurrent delinquency or regret and return to society. Some of the most important ones were family problems (such as parental quarrels, parental addiction, parental unemployment, and a history of a criminal conviction and parental imprisonment).

 Undoubtedly, one of the essential factors in the occurrence of crime is the environments in which the perpetrators deal with them. They are influenced by these environments whose personalities are shaped. Family, school, neighborhood, dropout, peer group, and general social determinants are influential in juvenile delinquency and its continuation or abandonment.

The Dracocephalum kotschyi Boiss.is a wild-growing flowering plant belonging to the Lamiaceae family and has been used as a medicinal herb for rheumatoid diseases, headaches, congestion, stomach disorders, liver treatment. In order to study the effects of dryland farming system on some agronomical and physiological traits of D. kotschyi, two separate experiments were conducted in three locations of, Mashad (Golmakan station), Quchan (5km in the northeast of city) and Bojnord (Sisab station) under normal irrigation and dryland farming systems in 2018. The collected data were combined analysis over three locations and mean comparisons were made using Tukey method. The results showed significant effects of locations for all of the traits except carbohydrate contents. Effect of farming system was also significant for all traits. Farming system by location interaction effects were significant for aerial fresh and dry weigh, 1000 seeds weight, proline, DPPH, flavonoid, protein, chlorophyll a, carotenoid, nitrogen and potassium. Result showed the location of Quchan had significantly higher mean values for many of traits followed by Mashad. In comparisons between two method of cultivations, the lower and higher values of plant height (20.6 vs. 25.3 cm), main branch (13.1 vs. 14.9 per plant), leaf area (38.9 vs. 48.3 mm2), flower number (14.6 vs. 23.1 per plant), fresh weight (295 vs. 888 g/plant), dry weight (80 vs. 244 g/plant), 1000 seeds weight (0.27 vs. 0.35 g), Protein (9.74 vs. 11.06%), chlorophyll a (7.47 vs. 8.19 mg g-1FW), carotenoid (0.08 vs. 0.11 mg g-1FW), nitrogen (1.43 vs. 1.77%) and phosphorus (13.89 vs. 20.79 ppm) were obtained in dryland and irrigation farming, respectively. In contrast, the higher and lower values of internode length (4.11 vs. 3.71 cm), proline (1.44 vs. 0.77 mg g-1FW), DPPH (0.39 vs. 0.19 mg g-1FW), phenol (0.83 vs. 0.67 mg g-1FW), flavonoid (0.60 vs. 0.47 mg g-1FW), carbohydrate (8.2 vs. 6.2 mg g-1FW), and potassium (4.2 vs. 3.7%) were obtained in dryland farming system.

Glioblastoma multiforme (GBM) is the most aggressive and malignant brain tumor and has a poor prognosis. This study was aimed to investigate the cytotoxic effects of Dracocephalum kotschyi Boiss. (D. kotschyi) extracts in GBM U87 cell line. The extracts of D. kotschyi obtained by two different ways of Soxhlet and soaked. The cytotoxic effects of D. kotschyi extracts were measured using MTT assay following treatment for different times of exposure (24, 48, and 72 hr) and at different concentrations of D. kotschyi extracts. The effects of D. kotschyi extracts on cellular oxidative stress were also evaluated by measuring cellular ROS levels. Furthermore, cellular death and apoptosis were studied by sub G1 analysis and Annexin V-FITC/propidium iodide (PI) staining using flow cytometry method, respectively. Characterization of the extracts was carried out using gas chromatography/mass spectrometry (GC/MS) analysis by Agilent GC-MSD system. Our results indicated thatD. kotschyi extracts decreased U87 cell viability in a time- and dose-dependent manner. Moreover, treatment with D. kotschyi extracted by Soxhlet for 24 and 48 hr significantly increased the levels of cellular ROS and Sub G1 population (p D. kotschyi mainly consisted of β-caryophellene, α-pinene and limonene. Our findings demonstrated that D. kotschyi extracts can exert cytotoxic effects against GBM U87 cell line in a time- and concentration-dependent manner, and these effects may be mediated through intracellular ROS accumulating. However, further studies should be performed to confirm the efficacy and exact mechanism of action of the extracts.

The rapid growth of IT applications and providing more services on computer networks comes with security threats with malicious and business targets. One method to deal with network traffic analysis complexities is to analyze a summary of network data that is extracted from network connections. Netflow is a defacto standard for generating network flow data introduced by Cisco and integrated into Cisco switches and routers which produce flow records about underlying network traffic. In this paper, we use machine learning techniques to analyze Netflow data and classifying connections pertain to network attacks and do respective prevention measures after the classification. Machine learning algorithms including Naïve Bayes, SVM, and NBTree has been used to model different attacks based on network flow data. In the evaluation phase, KDDcup99 dataset used and related features to Netflow data are selected (7 features), and then, classification has been done with both original KDDcup99 features (41 features) and our selected Netflow features. Average classification accuracy for different 22 attack classes and one benign class shows that using just seven Netflow related features does not affect the accuracy obviously while the computation overhead is obviously decreased. Average detection accuracy for our selected features in different algorithms is 97% whereas, for the best case (i.e, SVM) with 41 features, the average accuracy is 99% which is not so much better than our less complex Netflow based method.

Quality of life is a multidimensional concept that is influenced by many important factors such as physical and mental health. Health literacy is also one of the factors that has a significant impact on quality of life. The purpose of this study was to investigate the relationship between nurses' quality of life and health literacy in the largest heart center of Northwest Iran in 2018.

The present study is an analytical, cross-sectional study that was performed on 217 nurses working in the largest heart center of Northwest in Tabriz through random sampling. Study data were collected using the 36-item Quality of Life Questionnaire (SF-36) and the Adult Functional Health Literacy Standard Questionnaire (HELIA). Data analysis was performed using ANOVA, t-test, Pearson correlation coefficient, by SPSS software version 25.

The mean and standard deviation of nurses' quality of life was (59.17±7.6) and the majority of subjects 84(37.8%) had good quality of life. the mean and standard deviation of the overall health literacy was estimated to be 75.9 ± 13.3, indicating adequate health literacy among nurses. There was a significant relationship between different dimensions of quality of life with total health literacy score (P <0.001), but there was no significant relationship between understanding and quality of life’s dimensions.

Findings showed that increasing nurses' health literacy has positive effects on some aspects of their quality of life. Therefore, while communicating with nursing staff, nursing managers should pay close attention to their health and quality of life, and should try to improve their quality of life by developing educational programs and promoting health literacy.

Glioblastoma multiforme (GBM) is the deadliest type of primary brain tumors, and the survival of patients is estimated to be only about one year. This study, for the first time, investigated the cytotoxic effects of auraptene on U87 GBM cell line. The cellular toxicity was measured by the MTT assay following 24 and 48-hr treatment with different concentrations of auraptene (0-400μg/ml). Apoptosis was evaluated by sub-G1 peak in cell cycle analysis of propidium-iodide- stained nuclei. Moreover, to determine the Bax, Bcl-2, MCP-1, NF-κB, IL-1β, and p53 genes expression, we used real-time polymerase chain reaction (RT-PCR). The results revealed that auraptene reduced the viability of U87 cells concentration- and time-dependently with IC50 values of 108.9 and 79.17μg/ml obtained for 24 and 48-hr treatments, respectively. Also, sub-G1 population was significantly increased following 24 (p real-time RT-PCR showed an up-regulation in Bax, NF-κB, IL-1β, and p53 but a down-regulation in MCP-1 and Bcl-2 genes expression. This study showed that auraptene triggered apoptosis probably through Bax/Bcl-2 regulation, blocked cell cycle progression and inhibited proliferation in U87 GBM cells. Taken together, auraptene can be utilized as an effective natural medicine against GBM, after complementary studies.

Nowadays, using umbilical cord blood (UCB) as a rich source of hematopoietic stem cells has been an important issue for both researchers and physicians in many parts of the world. According to the benefits of using cord blood in curing disorders, awareness of parents about cord blood utility and cord blood banking is important. The aim of the study was to evaluate the knowledge and willingness of Iranian pregnant women and also the information level of doctors about cord blood banking.
This is a survey that conducted among at least 28 weeks 824 pregnant women and 152 Obstetric-Gynecologists (OB-GYNs) in private hospitals of 24 provinces of Iran to evaluate the knowledge using a questionnaire.
Our finding indicated that 38.7% of participants were aware of cord blood banking and less than 50% of doctors had complete information about cord blood usage. The mother’s attitude is related to their doctor’s recommendation. The results show that the level of education, employment status, and occupation, income has an impact on the parent’s attitude for cord blood banking.
The level of knowledge among the pregnant women about cord blood usage is low totally. Even the doctors had not complete awareness about cord blood banking. Hence the most of the women tend to get advice from their physician; we should try to introduce Royan cord blood bank and the advantages of cord blood stem cells via holding congresses and medical gathering.

This study aimed to compare the ratio of suicide attempts between female opium and Methamphetamine (MA) users to determine the relationship between the increased prevalence of MA and suicide risk.  In this cross-sectional study, 136 drug dependent females were randomly selected from Tehran. Data gathering was performed by a demographic questionnaire and Beck Scale for Suicidal Ideation. Data were analyzed by Chi-squared test and Independent Samples t-test. There was no significant different in suicidal ideation between the two groups; however, the suicide attempt was significantly higher in the MA users compared to opium users (P<0.001). Suicide attempt is much higher in females who use crystal MA, compared to female opium users. This could be a warning to prevent associated risks.

This article examines the meaning, the concept and the nature of the transformation what is transformation in the humanities as a software of modern Islamic civilization from the perspective of Ayatollah Khamenei. What is inferred from the descriptive-analytical method of Ayatollah Khameneichr('39')s statement is that the production of humanities, due to its intellectual dignity and its directional function, which is included in the feature of the software of these sciences, has an unparalleled role in the formation of civilization Modern Islamic. From his point of view, the concept of transformation in the human sciences has two intrinsic and constitutive components that make sense and meaning of the transformation. The first component of the concept of transformation in the human sciences is the negative approach to the existing humanities.The spirit of this negative form, the inevitable turning away from the Western humanities due to their intrinsic crisis, requires the revolution and reversal of these sciences in various fields of Foundations, principles, methods, orientations and ends, as well as their degradation from the position of "the axis of recognition and The ultimate knowledge of man "is. The second and final element of the nature of the transformation of the human sciences is a positive approach to the true production of Islamic human sciences. The truth of this evolutionary aspect is the complete rejoinder of Islamic thought, which relies on the texts and divine sources and Islamic culture of Islam in a scholarly way, and relying on such vast, profound and deep Islamic capacities, in a continuous, difficult and The vital way of the productive, institutionalized, and creative work of the Islamic Humanities is taking steps.

High prevalence of stimulants use –especially crystalline methamphetamine (crystal meth)-, which required extensive medical and rehabilitation interventions is a major problem in Iran’s health care system. Main objective of the current study was to compare social, economic and cultural factors associated with female’s tendency toward use of two main types of drugs including opium and crystal methamphetamine. The present cross-sectional and comparative study was performed on female opium and Methamphetamine (MA) dependents of Tehran in 2015. 136 women (82 crystal meth consumers and 54 opium consumers) were selected by simple random sampling method whom filled a researcher-developed questionnaire. Data was analyzed by Pearson Correlation Coefficient and Chi-square test using SPSS software V. 19. There were significant differences between two groups in terms of marital status (P=0.012), the believe in better fitness with drug use (P=0.011), and the believe in improved working and studying efficacy (P=0.039). It seems that misconceptions of beneficial impact of crystal methamphetamine use on fitness and improved working and studying efficacy could be recognized as a prominent factor for women’s tendency toward crystal methamphetamine use. Also, being single and avoiding a stable marital life was a strong factor associated with such tendency. This was whilst opium use was more prevalent among married women, and especially those influenced by their addicted spouse