جستجوی مقالات مرتبط با کلیدواژه « Growth Hormone Deficiency » در نشریات گروه « پزشکی »

Idiopathic growth hormone deficiency may be isolated or associated with deficiency of other pituitary hormones. the use of brain MRI findings to differentiate between the two groups can be useful.

This descriptive study of the retrospective method, investigates all 2–6-year-old children, who referred to Sari Gardener Clinic between 1390 and 1396 with a short stature complaint, and diagnosed them with a single growth hormone deficiency or multiple hypophysis hormone deficiency. Patient file information that includes demographic information, history and clinical examination information, laboratory information, and paraclinical information were extracted.

In this study, 150 patients, 63 of whom (42%) were girls, were evaluated. The mean age of the patients was 34.71 ± 113.63 months. 68.7% showed a slight deficiency of growth hormone and 31.3% showed a severe deficiency of growth hormone. A total of 6.67% had a significant deficiency of pituitary hormones and 93.33% had an isolated deficiency of growth hormone. 79.33% of patients had normal Brain MRI and 20.67% had abnormal MRI. The findings included hypoplasia and 41% loss of adenohypophysis, 2.56% ectopic neurohypophysis, 12.82% pituitary microadenoma, 25.64% partial empty sella, 7.69% Complete empty sella and other reported findings were 10.25%.

In this study Pituitary abnormalities in brain MRI have been reported in patients with multiple pituitary hormone deficiency more than in patients with isolated growth hormone deficiency, However, it has not been established that the pathological findings detected on MRI are consistently associated with permanent growth hormone deficiency.

Background and Growth hormone deficiency is the reason of growth disorder in children. Therapeutic response is related to the factors such as, age, drug dosage, numbers of administrations and duration of therapy. Researches have been done to clarify the relationship between therapeutic response with the maximum amount of GH secretion in stimulatory tests. Ïn order to study this relationship, a research was conducted in Boali endocrine clinic on referred patients. in 1997-1990. This study was an open clinical trial done on two groups of children with growth hormone deficienes. The patients were divided in two groups of  and B on the basis of maximum amount of growth hormone secretion on stimulatory tests. Group  included 11 patients, with maximum secretion of not more than 5 ng/ml. Group B, included 5 patients with maximum secretion of more than 5 ng/ml. Patients were matched for numerical and skeletal age, dosago and frequency of injection per week. Standard Deviation Score(SDS) for weight, height and the rate of growth were compared. The results were compared by paired T-test in the groups and T-test between the groups. The height growth, weight changes and also the growth rate in the groups were significant statistically. Weight SDS change was significant between two groups, but height and growth rate SDS changes between two groups was nor significant. Çonclusion: No significant changes was observed in group Â, which could be due to the less number of samples and much height growth SDS changes. Hence, further studies with more number of samples is recommended.