جستجوی مقالات مرتبط با کلیدواژه « Lipopolysaccharide of Brucella abortus » در نشریات گروه « پزشکی »

The incidence of inflammatory disease is increasing around the world. Conventional therapies in patients with inflammatory diseases unable to cure completely. However, recent studies have shown anti-inflammatory effects of angustifolia aqueous extract. The IL-6 cytokine level is increased in many inflammatory diseases and is recognized as a marker for inflammatory diseases. Therefore, this study aimed to evaluate the effect of angustifolia aqueous extract on IL-6 serum levels in mice receiving lipopolysaccharide of Brucella abortus. Subjects and Twenty five mice were divided into five equal groups. The control group did not receive the extract. The four next groups intraperitoneally received the different dose of 10, 20, 30 and 40 mg/kg of angustifolia aqueous extract daily for four days. All groups intraperitoneally received 100 g of lipopolysaccharide of Brucella abortus on the fourth day. Blood samples were collected by cardiac puncture. The sera were separated and kept frozen at −80°C and thawed shortly before determination of IL-6 levels by the ELISA kit. Our results showed that serum concentrations of IL -6 (pg/ml) in groups receiving angustifolia aqueous extract at dose of 10 mg/kg (P<0.05), 20 mg/kg (P = 0.o14), 30 mg/kg (P =0.012) and 40 mg/kg (P=0.023) significantly decreased when compared to control group (p <0.05). Keywords: Angustifolia aqueous extract, IL-6, Lipopolysaccharide of Brucella abortus.