جستجوی مقالات مرتبط با کلیدواژه « S. lugdunensis » در نشریات گروه « پزشکی »

Although Coagulase Negative Staphylococci (CoNS) were previously considered to be harmless bacteria, some species have recently been shown to be potential pathogens in humans. One of these species, which has emerged in nosocomial infections, is Staphylococcus lugdunensis. Given the importance of recognizing new infections in hospital settings and their prevention, the present study aimed to investigate the presence of S. lugdunensis in patients with burn injuries.
In this study, 124 CoNS isolates were evaluated in the patients admitted in a burn injury center in the southwest of Iran during January 2016-May 2017. The detected S. lugdunensis isolates were assessed in terms of drug susceptibility pattern, β-lactamase production, mecA-mediated oxacillin resistance, and inducible clindamycin resistance. The applied methods included disk diffusion, penicillin minimal inhibitory concentration, cefoxitin broth microdilution, and erythromycin/clindamycin disk diffusion, respectively.
Among the CoNS samples, 25 cases (20.2%) were S. lugdunensis. In the confirmed isolates, mecA-mediated oxacillin resistance was detected in 21 cases (84%), and 18 isolates (72.0%) produced β-lactamase. In addition, 23 isolates (88.5%) showed inducible clindamycin resistance. In the antibiogram pattern, more than 70% of the methicillin-resistant isolates were also resistant to chloramphenicol, trimethoprim/sulfamethoxazole, gentamicin, azithromycin, and ceftazidime.
According to the results, S. lugdunensis was the cause of a new infection emerging in the studied burn injury center. Considering the resistance of the isolates against the most routine antibiotics, vancomycin is suggested as an alternative. Due to the prevalence of S. lugdunensis in different hospital wards, it is strongly recommended that CoNS isolates be evaluated for the detection of this bacterium.

Traditional medicine/complementary alternative medicine may suggest new ideas to modern medicine in order to face new challenges however these concepts should be acknowledged based on experimental studies. We aimed to study the effects of onion (Allium cepa) juice on the normal flora of conjunctiva and eye lids, and to follow the histopathology changes of conjunctiva in an animal study. Twenty-four rabbits were randomly classified into three equal groups. Groups 1, 2 and 3 received fresh red onion juice, as an eye drop, into the right eye twice daily for; one week, one month, and two months, respectively. Microbiological sampling by sterile swabs was performed before and after the intervention. Cultural characteristics, including the growth rate and the kind of organisms, are reported. At the end of the study, pathological samples were collected from the inferior fornix. After the intervention, the number of positive cultures in the samples, collected from both the conjunctiva and eyelid, had decreased. Group 3 demonstrated the lowest amount of growth after the administration of the onion juice and the bacterial isolation rates from each organism had decreased. All pathological samples revealed some degree of inflammation. There was no evidence of metaplasia or dysplasia. There was no significant difference between the growth rates of organisms in the experimental groups using statistical analysis. According to our experiment, onion has an inhibitory effect on the growth of normal eye flora; although the duration of onion juice instillation did not show any significant effect on the group results. Hence, this finding is an initiating point for further investigations into the antimicrobial properties of this herb to treat common eye infections, including conjunctivitis and blepharitis.