نشریه دانشور پزشکی
پیاپی 109 (اسفند 1392)

Multiple sclerosis is the most common neurological diseases that cause disability in the nervous system which reduces quality of life. Stretching exercise is a low-cost and non-invasive method that can be used to improve physical health composite. The aim of this study was to determine the effect of stretching exercises on the physical health composite for patients with multiple sclerosis (MS). In this quasi-experimental study, 90 patients with MS were recruited from Tehran MS association and Sina hospital research center. Subjects were divided into two groups of experimental and control. MSQOL-54 scale was used to evaluate the physical health for both groups at first. Then, the correct way of exercises is taught to patients. Experimental groups did stretching exercise for 12 weeks, three times every week. Subjects in control group did not have any intervention. Quality of life was again measured in both groups after 12 weeks. Collecting method was based on personal information and MSQOL-54. The data were analyzed by SPSS software version 18. There were no significant differences regarding physical health at baseline in the two groups (p=0.82). There was a significant result that shows physical health score in experimental group increases as compared to control group (p<0.001). According to the present results, stretching exercise raises quality of life of multiple sclerosis patients. Therefore, this method is safe, simple, non-invasive and low-cost that is recommended.

Biochanin A a bioflavonoids in red clover and soybeans is well-known as an anti diabetic and anti lipidemic flavonoids. The aim of this investigation was to study the renal and hepatic effects of biochanin A in streptozocin-induced diabetic rats. Diabetes was induced in wistar rats، by administration of streptozocin (35 mg/Kg of body weight) intraperitoneally. Diabetic rats were treated with 10 and 15 mg/kg (body weight) biochanin A in 5% DMSO for 30 days. Body weight and biochemical parameters including fasting blood glucose level (FBG)، glycosylated hemoglobin (HbA1c)، lipid profile، aspartate aminotransferase (AST)، alanine aminotransferase (ALT)، alkaline phosphatase (ALP)، urea andcreatinine were assessed. The data showed، increasing in biochemical parameters such as body weight (BW)، FBG، HbA1c and lipid profile because of STZ induction، returned back to normal level after oral administration of biochaninA. The results showed significant increase in hepatic enzyme، urea and creatinine in STZ diabetic rats، but oral administration of biochaninA significantly decreased AST، ALT، ALP، urea and creatinine. The data of this investigation also indicate that protective effect of biochaninA on hepatic and renal tissues is greater in 10mg/kg compared to 15 mg/kg. Oral administration of biochanin A in addition of antidiabetic، anti lipidemic effect has a protective effect on hepatic and renal function. The data of this investigation indicate that Biochanin A، is not toxic.

The hospitalization length of admitted patients is very important for the management of hospitals. Due to the significance of this subject and few similar researches in this area, the current study has been done to model the number of days of stay for cerebrovascular accident (CVA) patients in Sabzevar Vaseyee hospital and to determine its relation with independent variables. The current study was designed on modeling the number of stay days for CVA patients in Sabzevar Vaseyee hospital in 2012. By using random sampling, 179 persons were selected and the value of the length of stay as the response variable and the value of gender, age and residence location of these patients as the independent variables were considered and count regression models and SAS9.2 software were used to analyze the gathered data. The obtained results of this study showed that the average of stay length for CVA patients is 5.13±2.67 (mean±standard deviation) in Vaseyee hospital. Also, the finding of the regression models used in this study presented that the length of stay of patients increases one day on the average for a one-year increase in patient’s age. Moreover, the relations between gender and residence location variables with length of stay variable were obtained. Due to the significance of the stay length of patients and because of its different values in different units and hospitals, the application of these advanced statistical models is also proposed in other hospitals and cities.

Maintaining independence and attention to needs of elder people have always been one of the main goals of care-givers and policy-makers in the field of elderly care. This study was performed to investigate the determination of care dependency among elderly residents of nursing homes in Ahvaz city in 2012. This research was a cross-sectional study of descriptive-analytical type which was carried out on 154 elders with an age over 60 years residing in nursing homes in Ahvaz city. Sampling was performed using stratified sampling method. Data collecting instruments were “Care Dependency Scale”, “Demographic Questionnaire” and “Mini-Mental State Examination”. For data analysis, Chi square test, one-way ANOVA, t-test independent and Pearson correlation coefficient tests were used. The results indicated that 72.7% of elderly were dependent. There was a high correlation between care dependency and aspects of care dependency scale (p<0.01). The mean score of care dependency was 47.38 and the mean items score of the care dependency scale for the total sample was 47.25. The variables age (p=0.03), education (p=0.001), having disease (p=0.001) and disability (p=0.032) had significant relationship with care dependency. In this study, elderly who were better in performing daily living activities certainly needed less care. The knowledge of elderly needs and their capability in performing daily activities may enable care-givers and families to provide more proper services with their need.

Menorrhagia is considered as one of the most common gynecological problems in childbearing age of women. Regarding the prevalence of this disease، the study examinesthe effect of Nettle extract in Menorrhagia improvementby statistical modeling. Thestatistical modeling has been performed by data on 100 patients with menorrhagia. 100 patients were randomly assigned to two groups - intervention group (Nettle and Mefenamic acid) and control group (placebo and Mefenamic acid) – with equal size of 50. In this study، joint longitudinal and generalized linear model were used for predicting the probability of recovery of women who participated in the study. Joint modeling with common random effects was performed by controlling variables such as age، body mass index to assess the impact of nettle extract on improving Menorrhagia patient. Based on results the average number of menstrual days in the third month (second cycles after intervention) were (5. 52 ± 1. 44) and (6. 19 ± 1. 82) respectively in Nettle and extract groups. The difference between the two groups was statistically significant (p =0. 023). The chance of improvement who are in Nettle group were 1. 5 times control group، but there was no significant difference of improvement between the two groups (p=0. 347). In general، joint model were more accurate than the conventional models. Probability of improvement was higher in the intervention group than the control group. Using Nettle extract in reducing the number of days of menstrual cycle in patients with menorrhagia has had a positive impact.

Down’s syndrome، as the most common chromosome disorder، is associated with several psychomotor and sensory disorders that can affect the nutritional status of patients. The aim of this study was to determine the nutritional and anthropometric status and taste and smell sensitivity of children with Down syndrome in Ahvaz. This cross-sectional study was done on 58 children with Down syndrome in exceptional and welfare centers of Ahvaz in 2011. Demographic، anthropometric and dietary data were collected by questionnaires، with interviewing with parents. Taste and smell sensitivity was assessed using the Short Sensory Profile questionnaire. Data analysis was carried out using SPSS17. 0 software and P<0. 05 was considered significant. Based on the growth charts for children with Down syndrome، 37. 9% and 34. 4% of children were above the 75th percentile، respectively in terms of weight to age ratio and BMI. Extracellular water to total body water was significantly higher in girls than boys. Dietary intake of fat was higher than its recommended values and the mean of taste and smell sensitivity score was 13. 5±2. 0. More than a third of children were obese according to weight / age and BMI. Eating more high- fat and high-calorie foods and higher sensitivity of them to taste and smell stimuli can be effective in their obesity. In this regard، the need to provide nutritional education to parents and correct dietary pattern is recommended

Social environment affects quality of life and causes physical and psychological disorders in children. Aim of this study was comparing the quality of life in abused and normal children by controlling roles of social anxiety، mood and feeling. The research design was non- experimental research. Participants were 60 children. With using available sampling method 30 abused children were selected from Center for Treatment of Social and Individual Crises and a Center of Street Children in Semnan in 2012. They were matched with 30 normal children by age and gender. They completed Pediatric Quality of Life Inventory، Social Phobia and Anxiety Inventory and Short Mood and Feeling Questionnaire for Children. The results showed by controlling social phobia، quality of life in physical dimension was different between two groups. By controlling simultaneous changes of children''s mood/feeling on emotional and social dimensions، and also، by controlling social anxiety on emotional and school dimensions، difference of quality of life in these dimensions between two groups weren''t significant statistically. Interventions should focus on social anxiety and mood/feeling for improving the quality of life in emotional dimension، while these interventions should focus on mood/feeling for improving social quality of life and should focus on social anxiety to improve school dimension

The aim of this research is comparison study of epidural by lidocaine، tramadol، and combinations in rabbit as a model for further research on methods of epidural anesthesia in humans. By experimental study 12 New Zealand white rabbits were divided into 3 groups of 4. In the first experimental group (L) used 4 mg / kg lidocaine 2%، for the second group (T) used 4/4 mg / kg tramadol and in third group (TL) the combination of lidocaine (2 mg / kg) and Tramadol (2/2 mg / kg) was used. Sensory block، motor block، heart rate، respiratory rate and rectal temperature، 10 min before injection and at intervals of 10 minutes to 90 minutes after injection was measured. Spss statistical analysis software and paired sample t-test used and significance level (p <0/05) were considered. Based on survey results in delayed onset of numbness and immobility of the drug tramadol (min 3 ± 0/3) significant increase in the lidocaine group - tramadol (min 1/25 ± 0/5) and lidocaine (1 min) was found (P <0/05). Also، the duration of numbness and immobility in tramadol group (min 5/2 ± 7/13) was most significantly reduced compared to the lidocaine - Tramadol (min 1/14 ± 20) and lidocaine groups (min 10 ± 30) (p <0/05).