Govaresh
Volume:19 Issue: 4, 2015

Gastric cancer as the fourth most frequent malignancy worldwide was known to have the highest rate among cancer-related disorders in Ardabil province. The product of TP53 gene regulated the cell cycle process and acts as a tumor suppressor factor. The polymorphism P53 Arg72Pro (rs1042522) has been reported to be associated with many type of cancers. The purpose of the present study was investigating about susceptibility of gaining gastric cancer in which probably conferred by the polymorphism P53 Arg72Pro in Ardabil province. Using PCR-RFLP، the polymorphism was assayed among 87 patients affected with gastric cancer and 92 healthy controls selected. The statistical significance was analyzed by logistic regression test. The mean of age for cases and controls were 64. 2 and 61. 9 years respectively. The frequency of genotypes for cases has been detected as 16. 3% for Pro/Pro، 41. 9% for Arg/Pro، and 41. 9% for Arg/Arg and for controls were 18. 5% Pro/Pro، 40. 2% Arg/Pro، and 41. 3% Arg/Arg respectively. There was not any significant association between this polymorphism and affecting to gastric cancer. Finding shows relationship between susceptibility of gaining gastric cancer in our province and the polymorphism rs1042522 could be due to genetic and population relationship between Ardabil population and Caucasians، and the selective advantage of the Arg allele in cold climates، as well. On the other hand، considering to the previous studies on the etiology of gastric cancer in Ardabil province shows، environmental factors such as nitrate have more important role bin conferring susceptibility to gain gastric cancer and some genetic changes and affecting to gastric cancer in this study indicates that the role of lifestyle improvement might reduce the huge rate of affected patients in our province.

Insulinoma was a rare pancreatic neuroendocrine tumor. Insulinoma was more likely to present as one small size tumor in head of pancreas in middle age. Surgery was a curative treatment. The aim of this study was to present clinical characteristics of insulinoma tumors in pancreas and their outcomes after tumor resection from a referral endosonography center in Iran.

this was cross sectional study from Nov 2010 to Nov 2013، all patients with clinical and biochemichal diagnosis of insulinoma entered to the study. Various characteristics likes، symptoms، laboratory and imaging findings،pathologic reports and their outcomes after surgery were recorded in a standard check list. Patients were followed for up to three years. All statistical analyses were performed SPSS software.

A total of 42 patients (62% women; mean of age 40 years) were identified. All of patients reported Whipple’s triad. Mean time from initiating of symptoms untill diagnosis time was 14 months. The common blood type was O (n=22،52. 3%). The mean tumor size was 2. 7cm. 33. 4% of endosonography reports show a solid tumor in the head of pancreas. Finding shows (n=36، 85%) of patients were treated surgically. Insulinoma tumor was confirmed in the pancreatic sample. Insulinoma recurrence have not report during the mean follow-up of 343 days in patients after tumor resection.

In this study، insulinoma tumors of pancreas (non familial) were single with tumor size of less than 3 cm. Most of them located in the head of pancreas. Outcomes following complete resection of tumor were satisfactory and have not report tumor recurrence during up to 3 years follow up. These results were the same as reports from other countries.

The rapid development of the mining and industry activities increased and many toxic metals in the environment of the earth''s crust has been dissipated and t has taken risks to human exposure، inhalation. Today evidence of many diseases associated with environmental factors harmful to repellent Bio systems is increasing gradually، The majority of these factors were man-made and the activities associated with heavy metals was a major threat for human health. Mercury has the most toxic non-radioactive element that was already known. The purpose of this study was to investigate the effect of mercuric chloride intra peritoneally on blood albumin and some liver enzymes. In this study، 30 male Wistar rats randomized selected into 6 groups (1 control group، and experimental groups of 1، 2، 3، 4، 5). In control group adequate serum physiology، and in experimental groups a dose of mercuric chloride infused into peritoneal cavity for 7 days. The amount of mercuric chloride infused were 1 mg/kg in 1st group، 2 mg/kg in group 2، 5 mg/kg in group 3، 7 mg/kg in group 4، and 10 mg/kg in the fifth group every other day for for 7 days. After the 7 days blood samples، were tested and analyzed. In this study، there was a significant relation between decrease in albumin levels in experimental groups compared to the control group and a there was significant relation increase in the amount of transaminases; SGOT and SGPT in the experimental group This study showed that intra peritoneal injection of mercuric chloride causes the balance were increased. of liver enzymes and serum albumin levels.

Various studies on prevalence of celiac disease in patients with irritable bowel syndrome in Iran is available that Chiefly، the prevalence of this disease and its association with several factors have been investigated. In order to gain a better perspective of Iran and spread across the heterogeneity، all studies included in the systematic review، the findings were analyzed and used a meta-analysis. All articles published in Iranian journals and international research project، related papers presented at the Congress، and the Student thesis، in this study used standard and sensitive keyword. All the articles published in this field in the country، where inclusion criteria for assess quality control using random effect، and the meta-analysis were entered. In 7 studies، minimum and maximum prevalence of celiac disease in patients with irritable bowel syndrome، 2/59 % and 13/5 % was calculated، and total prevalence of this disease based on fix effect model 6/26 %، with the heterogeneity index equals Q =13/74 (t2=52/05 and I2=56) and reliability 99% (x2=16/8) was estimated and because of the high heterogeneity based on random effect model، total and final prevalence of the celiac disease in IBS patients 7/59%، with the heterogeneity index equals Q=2/05 (t2=0 and I2=19) and confidence 95% (CI =8/07-7/23) were counted. Also by using method of meta-regression، main factors causing heterogeneity، variable location، time، and gender of patients were identified. (p<0/01). Considering that the prevalence of celiac disease in patients with irritable bowel syndrome in the country is high، with knowledge and research-centered measures، total level of health in the country should be raised and daily، in the direction to the horizon landscape of civil and global health charter progressed.

Today investing about the role of contributing emotional factors in etiology and treatment of functional gastrointestinal disorders was an interesting subject for many researches. The purpose of the present study was to assess the relationship between emotional intelligence and somatization in patients with functional gastrointestinal disorders.

This study was descriptive and correlation. In this study 240 patients with functional gastrointestinal disorders (42 male and 198 female) were selected by the convenience sampling and participated in the study by filling baron emotional intelligence scale (1970) and Modified somatic Perception Questionnaire (MSPQ). Data was analyzed and used Pearson correlation and multiple regressions.

The results show that emotional intelligence had significant relationship in patients with functional gastrointestinal disorders. There was an association between increasing in scores of emotional intelligence and decreasing in scores of somatization. Also، adaptability and stress management among dimensions of emotional intelligence had significant and contrary relationship with somatization. The results of regression analysis show that emotional intelligence predicts 10 percentages of somatization scores in these patients.

The results of the study highlight the protective role of emotional intelligence in physical and psychological health and provide useful information for medical and psychological treatment of patients with functional gastrointestinal disorders.

Psychological factors have important role in vulnerability and maintenance of Functional Gastrointestinal Disorders (FGID). The aims of present study was the comparison of early maladaptive schemas and cognitive emotion regulation styles in FGID patients and normal group. For this purpose from Functional Gastrointestinal Disorders population that referred to therapeutic centers of Urmia city selected، 90 patient with FGID diagnosis and 90 normal group selected by purposive sampling. Data collected by YSQ-SF and CERQ، then analyzed by MANOVA method. Findings shows that two group significantly differed of early maladaptive schemas particularly in Impaired Limits and Over vigilance and Inhibition domains، but there was not relation in cognitive emotion regulation styles. Early maladaptive schemas can be influence Functional Gastrointestinal Disorders (FGID)، and should be considered.

Data mining has an interdisciplinary field including various scientific disciplines such as: database systems، statistics، machine learning، artificial intelligence and the others. In the field of medical، data mining algorithms can help physicians to diagnose diseases and chose the best type of treatment. Hepatocellular carcinoma has the most common type of liver cancer. Given the poor prognosis، Hepatocellular carcinoma (HCC) has the fourth leading cause of cancer-related deaths. In this article we aimed to build a decision support system which helps physicians for identify patients at risk to liver cancer. We analyzed 258 patients with cirrhosis liver. Patients have followed up for four years. We have used decision tree as a data mining tool، for identify patient at high risk to Hepatocellular carcinoma. Decision tree determined the importance of attributes such as creatinine، INR and BMI which could be useful for prediction of cancer. From decision tree model، cirrhosis disease classification rules were extracted and used to improve the prediction of HCC. Decision tree could identify patients at risk to liver cancer with the accuracy of 88% for patients with Sustained virological response (SVR) and the accuracy of 92% for patients with non SVR found. According to decision tree results، attributes such as etiology، age، BMI، Platelet، Total Bilirubin، INR، Creatinine، Alfafetoproteina (AFP)، and Serum Albumin can predict HCC in patient with cirrhosis. It is suggest that results examine with a greater number of patient.

Prognosis of small intestine Artesia، the most common agents causing intestinal obstruction in neonates، has improved in last decades. Some variable such as weight change، type of feeding، post operation oral feeding starting time، and adequacy of energy and protein intake can change patients clinical outcomes. We performed a retrospective study to evaluate all neonates with small intestinal Artesia who were admitted to pediatric intensive care unit (PICU)، during 2002-2010 and followed-up their clinical outcomes over an 8-year period. We reviewed medical records of all patients with small intestinal atresia treated at Dr. Sheikh hospital in the between 2002 and 2010. Information of all patients were recorded، including demographic data، type and location of atresia، other problem or anomalies، being term or preterm، term of stay and length of hospitalization، weight change، type of feeding، post operation oral feeding starting time، and adequacy of energy and protein intake. 65 neonates presented with small intestinal atresia treated at Dr. Sheikh hospital during 2002-2010 entered our study. The age of neonates at admission time was median 3 days (1 day – 2 month). The median weight at reception was 2. 32 0. 6 kg (ranged 0. 75-3. 85 kg). The median of hospitalization period was 15 days. The mean amount of delivered calorie- protein and energy intake was significantly lower than the guidelines of the American Society for Parenteral and Enteral Nutrition (P<0. 001). We recommend full investigation of congenital anomalies and possible prevention of infections and its resultant sepsis in all infants with intestinal atresia، in order to reduce the risk of mortality in these infants.