فهرست مطالب
Govaresh
Volume:20 Issue: 2, 2015
- تاریخ انتشار: 1394/05/21
- تعداد عناوین: 9
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Pages 79-84BackgroundNon-alcoholic fatty liver disease (NAFLD) was one of prevalent problems in general population. It was the most common cause of abnormal liver function tests and may lead to steatohepatitis and cirrhosis. The role of many factors has been known in NAFLD. In this study، we investigated the correlation of serum magnesium level and NAFLD after minimizing the role of major confounding factors.Materials And MethodsThis was a cross-sectional study in the referral patients to the internal medicine clinic. We grouped study patients in two; patients with and without NAFLD. Then، serum level of magnesium was measured، and its relation was studied between both groups.ResultsWithin patients enrolled into study، 55 had NAFLD، and 33 were without NAFLD. Both groups were matched for main confounding factors، including: gender، diabetes and metabolic syndrome (p>0. 05). Mean serum magnesium level was 2. 26+/-0. 35، 2. 25+/-0. 39 and 2. 08+/-0. 41 in patients without NAFLD، grade one and two NAFLD، respectively (p=0. 06). However it was shown that with each unit increase in serum level of magnesium، risk of fatty liver disease would decrease 50 percent. (OR=0. 516، CI=95%،0. 147-1. 8060. 147-1. 806)ConclusionIn the current study، we evaluated the relation between serum magnesium level and NAFLD. We showed that patients with a lower serum level of magnesium have 50% more chance to get NAFLD، and it is correlated with higher degrees of fatty liver disease.Keywords: Non, Alcoholic fattly liver, Magnesium, Cirrhosis
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Pages 85-89Background
An elevation in the mean percentages of the gamma delta T lymphocytes per total T cells in the epithelium of the small intestine has a diagnostic value for celiac disease. This study aimed to measure the percentages of the peripheral blood gamma delta T lymphocytes in the adults'' celiac disease and healthy controls.
Materials And MethodsIn this case-control study the absolute numbers of the peripheral blood lymphocytes obtained from the controls (n = 21) and celiac patients (n = 15) were studied، Using a cell counter. The proportions of the gamma-delta T lymphocytes were evaluated by the flow cytometer method.
ResultsThe results showed that there was not significant I difference in the percentages of the gamma-delta T lymphocytes between celiac patients and healthy individuals (P value= 0. 84).
ConclusionsCollectively، the data show that the percentages of the peripheral blood gamma delta T lymphocytes could not be helpful for celiac disease diagnosis.
Keywords: Celiac disease, T lymphocytes, Peripheral blood -
Pages 90-96Background
Pentoxifylline might have a role in the suppression of inflammatory cytokines in non-alcoholic fatty liver disease (NAFLD). The aim of study was to evaluate the effect of Pentoxifylline on liver function tests in non-diabetic subjects with NAFLD.
Materials And MethodThis clinical trial was performed in 120 NAFLD patients. They were divided to two groups by Balance Block Randomization method. A dietitian in both arms performed regulation of daily calorie intake. Pentoxifylline was prescribed to intervention arm at the dose of 1200 m/g per day. Liver function tests were checked at 2 months interval up to 6 months.
ResultsFifty-four patients in control group and fifty-six ones in Pentoxifylline group were evaluated. The participants mean of age was 36. 65 ± 8. 82 years. The mean aminotransferase levels were not statistically different in two arms at the study period. However، the speed of aminotransferase reduction was faster in Pentoxifylline arm. The mean aminotransferase levels were decreased during the study period in each arm.
ConclusionPentoxifylline was not effective in reducing aminotransferase in NAFLD patients.
Keywords: Fatty liver, Pentoxifylline, Aminotransferase, Lifestyle modification, Diet -
Pages 97-105Background
H. pylori infection in the stomach was the first major cause of gastritis and peptic ulcer disease and gastric adenocarcinoma and lymphoma (MALT). Evaluation of the infection eradication is important. H. pylori infection was associated with gastric glands dysfunction such as increased serum gastrin and increased secretion of Pepsinogen. In recent years the measurement of serum gastrin and pepsinogen were considered to evaluation of Helicobacter pylori eradication.
Materials And MethodsIn a case - control study، we evaluated the changes of serum pepsinogen type 1 and 2 in H. pylori-positive patients after eradication therapy، and we assessed the correlation of serum pepsinogen type 1 and 2 and with successful eradication therapy.
ResultsPepsinogen type 1 and 2 serum levels significantly decreased after successful eradication in comparison with unsuccessful eradication. The both 2 markers decreased after 8 weeks of therapy. Pepsinogen 1 by a 41. 1% decrease in 8 weeks after eradication had 95% sensitivity and 100% specificity for successful eradication. 64. 1% reduction in pepsinogen 2، 8 weeks after treatment had 97. 5% sensitivity and specificity for successful eradication.
ConclusionAccording to the findings of this study and other previous studies، changes in the type 2 pepsinogen serum levels، can be a reliable indicator of successful eradication of H-pylori infection. Although our study showed that changes in pepsinogen 1 levels have a sufficient sensitivity and specificity of treatment، but in our study some factors including atrophic gastritis and age that affected on type 1 pepsinogen serum levels، did not considered.
Keywords: H.pylori eradication, Pepsinogen 1, Pepsinogen 2 -
Pages 106-110Strongyloidiasis disease caused by the Strongyloidesstercoralis nematode. This disease mainly affects the intestines. Sometimes the symptoms were similar to inflammatory bowel disease which may lead to misdiagnosis and lack of effective treatment. A 46-year-old male patient who complained of occasional diarrhea، sometimes with blood، about two months ago consulted with an internist. He had colonoscopy and ulcerative colitis was diagnosed without biopsy. The patient was treated with Mesalamine together with Prednisolone. The patient''s symptoms improved within the first two weeks، but after the third week got worse and he referred to a gastroenterologist. The patient then underwent colonoscopy and biopsy was done this time. In the biopsy، Strongyloidesstercoralis larvae were observed. Prednisone and Mesalamine were stopped and Ivermectin tablet was administered. Patient''s symptoms improved within a week to ten days and one year after treatment patient did not express any complaint. For diagnosis of ulcerative colitis،In addition to the colonoscopic observations، biopsy is necessary. Especially in the northern regions of the country، before initiating treatment with immunosuppressive and steroid drugs and/or if no response to treatment، it is necessary to think about strangyloidiasis.Keywords: Strongyloidiasis, Ulcerative colitis, Bloody Diarrhea
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Pages 111-119
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Pages 122-134Today’s knowledge on oesophageal adenocarcinoma and its rising incidence has encouraged researcher to illustrate relationship between Barrett’s disease and progression to adenocarcinoma. The incidence of this disease has been accelerated sharply in current decades since people life has changed. Studies have been demonstrated that several potential factors including genetical and environmental factors are involved on Barrett’s transformation. Using different detectable biomarkers and techniques have supported early recognition of adenocarcinoma but still have not clarified pathogenesis of Barrett’s oesophagus to oesophageal adenocarcinoma. This review summarizes as much as information in relationship with those evidences that have been finalised in different aspects of cellular and molecular pathogenesis of OA. However، current data shows that bacteria might play new role in the pathogenesis of adenocarcinoma.Keywords: Barrett's oesophagus, Oesophageal adenocarcinoma, Incidence
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Pages 135-140BackgroundBlood born viral infections such as hepatitis B virus (HBV) are major concerns in chronic hemodialysis (CHD) patients and hemodialysis units. Undetected HBs Ag in the presence of viral DNA، occult HBV infection (OBI)، is a concern in the care of CHD patients and hemodialysis unit as a mode of transmission.ObjectivesIn this case-control study we compare the frequency of OBI in the CHD patients with the normal population.Materials And Methods82 consecutive CHD patients and 82 healthy individuals without any risk factors for HBV infection were enrolled in this study. A selection criterion was negative serum HBs Ag by ELISA method. Subsequently، the sera were tested for HBV DNA by nested PCR method.ResultsIn the CHD group، 55 (67. 1%) were male and 27 (32. 9%) were female، with the overall mean age of 54. 32 ± 13. 67 years old. The mean age of control group was 32. 65 ± 8. 51 years old، with 26 (31. 7%) male and 56 female (69. 3%). HBV DNA was present in 9 (11%) CHD patients، 4 (8%) of whom were seronegative for anti-HBc and anti-HBs antibodies. No HBV DNA was identified in the control group (p<0. 0001). History of blood transfusion was present in all OBI CHD patients and 59 (80. 9%) of non-OBI CHD patients. Duration of hemodialysis in OBI CHD and non-OBI CHD patients were 73. 56 ± 39. 53 and 44. 24 ± 24. 59 months، respectively (p =0. 002).ConclusionThe prevalence of occult HBV infection is relatively high in patients with chronic hemodialysis in our region. Duration of hemodialysis and history of blood transfusion are important risk factor for OBI infection. A more sensitive method، such as PCR، may need to be considered in this patient population.Keywords: Adolescent, Adult, Age Factors, Biological Markers, Hepatitis B
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Pages 141-144There is still been no report of splenic involvement in the wake of colon cancer. In this case، air was seen in the spleen and liver following the penetration of colon cancer to the continuous spleen. Colon cancers always do not present with clear and common symptoms. Some times with a non-specific and uncommon symptoms and signs present that would be amazed physicians and researchers. It is very rare that we present، a middle aged man who presented with abdominal pain and rectal bleeding and in our investigation was seen air in spleen and liver in CT scan study. After surgery we found that air in spleen and liver is due to infiltration and invasion of splenic flexure colon cancer to spleen. Has had no cases of invasive colon cancer that causes the air in the spleen and liver have been reported.Keywords: Colon Cancer, Spleen, Invasion