مجله علمی پزشکی جندی شاپور
پیاپی 33 (شهریور 1381)

Cyclosporine is an immunosuppressive drug which is widely used among the patient with organ transplantation, psoriasis. rheumatoid arthrtis, etc. Since ladies at reproductive age may use this drug, the effect of cyclosporine on the resorption and absorption of the embryo should be assessed. For this reason,many outbreed white mice were kept in normal conditions and diet for a long time.A day after mating, the observation of vaginal plug in the female mice was considered as pregnancy.The pregnant mice were divided into test and control groups. The test group received cyclosporine solved in olive oil and the control group received only olive oil intraperitoneally on the 7th,8th and 9th days of pregnancy.After laparatomy the embryos were removed from uterus.The number of embryonic absorption site and normal embryos were counted.The obtained data were analysed by t-test and Mann-whitney testIt was found that cyclosporine crossed the placenta and caused absorption of mice embryos. The number of embryos in the test group was less than that of the control group, 9.44 for each control mouse and 3.7 for each experimental mouse (P<0.001). Embryonic absorption sites in the test group were more than that of the control group, zero for each control mouse and 4.8 for each experimental mouse (P<0.001).It is recommended that pregnant woman and physician don’t use or order cyclosporine as far as possible until more research is done on the subject.

although anatomic reduction and internal fixation of calcaneal fracture has become the preferred treatment but. becouse of too much difficulty to obtain this aim and so many complication afte that. varius closed treatment are still advocated by many orthopaedists. this studay is result of conservative treathment of 70 calcaneal fractures by short time splint & early range of motion of foot & ankle. 92/5% men. and 88% was between 20-50 years old 97% of the patients achive good results with minor syptoms wich did not interfere ththeir occupation.

Organochlorine Pesticides are important groups of chlorinated compounds which have been used for different purposes from the beginning of the 20th century.The bioaccumulation and biomagnificantion of these compounds within various food chains is a direct consequence of their chemical stability and lipid solubility.However, even with the ban of their application by WHO and Iranian authorities, it is thought that, some of the organochlorine pesticides are still used in Iran. The aim of this investigation was to identify and determine the above mentioned organochlorine pesticides in Karoon River water by a new HPLC method. Determination of their residues in Karoon River water can be considered as an index of their presence in living organisms of Khuzestan province.In this research, samples were collected from 16 stations along Karoon River and also from tap water in the Winter and Autumn of 1999. Extraction was carried out by liquid-liquid extraction method with n-hexane. Clean up process was done by floricil column chromatoraphy. Indentification and quantification of each component was performed by a new reverse phase HPLC method. A spherisorb (25*0.46cm) 5μm ODS column was used as stationary phase, mobile phase was composed of acetonitrile: methanol: water in ratio of 44:40:16 respectively, with a flow rate of 0.7 mL/min isocratically. A UV detector set at 218nm was used as detection system.Method validation showed that recovery, coefficient of variaition, detection and quantitation limits were quite satisfactory, which are described in the paper. Results obtained indicated that the concentration of the above mentioned organochlorine pesticides in the tap water were negligible, but in the samples of Karoon River, they were in the range of 0.013 to 9.2 μg/L.

It is more than 4 decades which haemodialysis has been used as replacement therapy in ESRD, but it has not been clear yet, what amount of dialysis an uremic patient needs. There are multiple methods for assessing the adequacy of dialysis. The aim of this study was to assess the adequacy of dialysis based on urea kinetic modeling, in hemodialysis center of sina hospital in ahvaz.74 Patients (43 men and 31 women) were studied. 39 of the patients have been dialysed twice and the rest of them thrice weekly. Their mean age was 50 years. KT/V, nPCR and TAC (urea) was calculated in all them.Based on KT/V,85% of patients in thrice weekly group and 97. 44% in twice weekly group have inadequate dialysis. The mean of nPCR in the patients was significantly lower than normal (p < 0.001).The difference between the mean of nPCR in two groups (twice and thrice weekly) was significant (lower in former group). This implies that low protein intake may be the result of lower dialysis dose.Although nearly all of patients had a TAC (significantly lower than 50 mg/dl, but with respect to the nPCR results (that show low protein intake in the patients), we can not use the TAC (urea) results as a marker of adequacy in them.The above results indicaled that another study should be planned for determining the reasons of dialysis inadequacy and malnutrition in these patients.