مجله دانشکده پزشکی اصفهان
پیاپی 136 (هفته چهارم خرداد 1390)

Most previous studies were concentrated on plasma beta-endorphin (ß-EP) and cortisol responses following sub-maximal or maximal exercise; however, little researches have been conducted on the efficacy of sports specialized exercise sessions in ß-EP and cortisol secretions. The aim of this study was to assess changes in plasma beta-endorphin and cortisol levels in male sprint swimmers after one session of swim exercise training. 15 healthy male elite swimmers as purposefully and voluntarily participated in an semi-experimental study. After a practice session for 2 hours long swimming, participants were swimming in a 50 meters standard pool with an intensity equivalent to 80-85 percent of maximal oxygen consumption. Venous blood samples were taken from the right arm of the subjects to measure levels of beta-endorphin and cortisol in the three steps: 1. Basic conditions, 2. Immediately after specialized training, and 3. 30 minutes after exercise. Serum blood samples separated immediately in refrigeratored centrifuge in +4 °C and then were transferred to assess the variables to the refrigerator -70 °C. Beta-endorphin and cortisol were measured by ELISA kit. Data were analyzed using repeated measures ANOVA test. There are significant differences between levels of beta-endorphins of male sprint swimmers in the three periods of time before, immediately after and 30 minutes after exercise (P < 0.05). The paired comparison test showed a significant difference between the mean beta-endorphin before and recovery period in the swimmers (P < 0.05). Also, results showed that the changes of cortisol levels in three steps were not significantly different. The results showed that an acute exercise session increase only serum beta-endorphins hormones in sprint swimmers.

To evaluate refractive, visual, topographic, and wavefront outcome of photorefractive keratectomy (PRK) for treatment of myopia and myopic astigmatism with two different excimer laser systems: Technolas 217z and Lasersight LSX excimer lasers.

183 eyes of 95 patients enrolled in this clinical trial. Patients underwent PRK in a Sadra refractive surgery center with Technolas or Lasersight system by a single surgeon between 2007 and 2011. For PRK we used Technolas 217z in one group and Lasersight LSX excimer laser in another group. Subjects examined before and 24 months after surgery evaluating vision, refraction, Orbscan topography, and Wavefront analysis. Data collected, analyzed with SPSS 16. We used Student t-test for statistical data analysis.

83 eyes were in the Lasersight group and 100 eyes in the Technolas group. Pre-op spherical equivalent refraction was not different in two groops. After surgery it was -0.93 ± 0.73 in Technolas and -0.19 ± 0.40 in Lasersight group, the difference was statistically significant (P < 0.001). Post-op difference vector of astigmatic correction was 0.44 ± 0.58 in Technolas and 0.41 ± 0.26 diopters in Lasersight group (P = 0.04). Post-op LogMAR Acuity was 0.015 ± 0.027 in Technolas and 0.0005 ± 0.005 in Lasersight group (P < 0.001). Post-op Q value of asphericity was 0.24 ± 0.33 in Technolas and 0.46 ± 0.37 in Lasersight group (P < 0.001).

Post-op spherical equivalent refractive outcome, best corrected distance visual acuity and satisfaction were better in Lasersight group. We did not find any difference regarding post-op wavefront analysis between groups.

Serum biomarkers can be used as alternative method for liver biopsy in order to assess the level of fibrosis in patients with chronic Hepatitis C. The determination of Hepascore is a non-invasive method to assess the level of fibrosis among patients. This study aims to compare the liver biopsy results with Hepascore among the Genotype 1 Hepatitis C patients in Isfahan.

A sample of 39 patients with chronic Hepatitis C is selected through the simple non-random sampling method for a liver biopsy and Hepascore test. After biopsy, the patients are categorized based on the Metavir scoring system. The Hepascore algorithm is computed based on age, sex, total Billirubin, δ-glutamyl transferase, α2-Macroglobin, Hyaluronic acid. Using the Spearman and ROC test in SPSS15, collected data have been analyzed.

The liver biopsy results showed 6 patients with F0, 12 patients with F1, 10 patients with F2, 3 patients with F3, and 8 patients with F4. The Hepascore value above 0.37 cut off point for detecting significant level of fibrosis has shown 67% sensitivity, 61% specificity, 67% positive predictive value, 61% negative predictive value. For a Hepascore value above 0.66, the results are: 82% sensitivity, 89% specificity, 75% positive predictive, 89% negative predictive value. For a Hepascore value higher than 0.84 for detecting cirrhosis, the results are: 100% sensitivity, 97% specificity, 89% positive predictive, and 100% negative predictive value.

This study shows that the Hepascore method is accurate enough to measure the level of fibrosis, particularly cirrhosis. Therefore, it can use for screening of patients that need liver biopsy.:

Multiple sclerosis (MS) is a chronic progressive disease which influences the brain, spinal cord, and other parts of nervous system and women are diagnosed with the disease 2 to 3 times more frequently than men. The purpose of this study was to evaluate the influences of yoga on depression in women with multiple sclerosis. Thirty women with multiple sclerosis from Isfahan multiple sclerosis Association volunteered to participate in this study. They were randomly divided into two groups of 15 people: control (age: 31.06 ± 9.7 y; height: 159.46 ± 3.83 cm; and weight: 59.1 ± 11.37 kg) and experimental (age: 35.73 ± 8.3 y; height: 161.9 ± 4.46 cm; and weight 59.53 ± 10.48 kg). The experimental group practiced yoga for 8 weeks (two sessions a week) under the supervision of a yoga teacher in class, and also one session a week at home for 60-75 minutes, while the control group performed only their everyday activities. The depressions of all subjects were evaluated at the beginning and in the end of the study using Beck questionnaire. Date was analyzed using student t-test. The depression in the experimental group decreased significantly (P < 0.05) after 8 weeks of yoga. No significant change was observed in the control group (P > 0.05). It can be concluded that yoga can be considered as a useful modality in treatment of the depression disorder in women with multiple sclerosis.

Hydatid cyst is a zoonotic disease caused by infestation of tape worm of the genus echinococcus. The most commonly encountered form of hydatid cyst caused by echinococcus granulosus or dog tapeworm. Liver and lung are usual locations of infestation. Locations other than liver, lung, and spleen are found in 6 percent of patient that most of those are secondary hydatid disease. Primary pelvic occurrence is less than 2 percent. Case Report: we report a rare case of primary hydatid cyst infestation of perianal location in a 56 years old man from a rural area. He presented with an inflammatory mass that seemed to be a perianal abscess. Pathologic report of drained materials confirmed hydatid cyst.

It seems to be necessary, especially for physicians working in endemic area such as sheep and cattle-rearing regions, to be more familiar with unusual presentations of hydatid cyst.