مجله دانشگاه علوم پزشکی مازندران
پیاپی 90 (تیر 1391)

Background and

Health related quality of life (HRQOL) is a main outcome in irritable bowel syndrome (IBS). Several psychological factors are mentioned as effective factors in determining HRQOL in IBS patients. The aim of this study is to determine the association between patient’s illness perceptions and HRQOL in IBS sufferers.

In this cross-sectional study 160 patients with IBS who were referred to psycho-somatic clinic (related to Noor hospital of Isfahan) were participated. Patients’ illness perceptions and HRQOL were assessed by Brief Illness Perception Questionnaire (Brief-IPQ) and IBS specific quality of life questionnaire (IBS-QOL-34). Information gathered from questionnaires was finally analyzed by descriptive statistic methods, Pearson correlation and Canonical correlation method.

Results of analysis performed by canonical correlation method showed significant association between patient’s illness perception and HRQOL in IBS sufferers (Canonical correlations: 0.84, P<0.001). Among illness perception subscales, Emotions (P<0.001, r=0.69), Consequence (P<0.001, r=0.67), Identity (P<0.001, r=52), Concern (P<0.001, 0.51), Timeline (P<0.001, r=49) and Personal Control (P<0.001, r=0.19), respectively, had the most significant correlation with HRQOL, and there was no relation found between Illness Comprehensibility or treatment control and HRQOL.

Patient’s illness perceptions seem to play a role in determining HRQOL in IBS sufferers. Therefor [psychological interventions based on patients’ Illness perceptions are recommended for these patients.

Background and

Febrile seizure is the most common type of seizure in children and a variety of causes are considered to be responsible for it. There are some reports that some trace elements may have a role in febrile seizure (FS). The aim of this study was to evaluate and compare the serum magnesium (Mg) levels in 3 groups: children with FS (A), children with fever without Seizure (B) and normal children (C). Relation between fever and serum magnesium level, was another goal of this study.

The aim of this case-control study was to evaluate and compare the serum magnesium (Mg) levels in 3 groups. In this study subjects in magnesium evaluation included 94 cases of A, 93 patients of B and 40 children of C. Each groups were matched for age, sex, weight and hemoglobin. The age range of children was 6 months to 6 years. The Mg levels in serum were analyzed by atomic absorption spectrophotometer. Data analyzed with Independent-Samples T Test and Pearson correlation coefficient.

The mean fever in A group was 0.40 ± 38.8 and B group 0.44 ± 38.4 ºC (Auxiliary temperature). The mean Mg level in A group was 15.6627 ± 2.8599, in B group 14.6157 ± 1.9769 and in C group 19.4479 ± 1.8619 mg/L. The mean serum Mg levels were decreased in A and B groups when compared with normal children (p<0.001), and also significant decrease were observed in serum Mg level in B group in compare with A group. (p<0.005) There was invert significant relation between Mg levels in serum on A group and fever. (PC= -0.312 and p<0.005(

It was revealed that zinc and magnesium play an important role in pathogenesis of febrile seizure and fever severity in children with fever without seizure.

Background and

Surgical site infections are infections of the tissues,organs,or spaces exposed by surgeons during performance of an invasive procedure,and the development of SSIs is related to the degree of microbial contamination of wound during surgery,duration of the procedure,and host factors.Inguinal hernioplasty is one of the most common surgical operations. The use of prophylactic antibiotic in Lichtenstein hernioplasty is controversial. Hence this study done to evaluate the prophylactic antibiotic effect in reducing the post operative wound infection in Lichtenstein hernioplasty.

This is an interventional double-blind randomized trial on 282 patients under going, Unilateral primary elective inguinal hernioplasty with Lichtenstein method. Using polypropylene mesh. They were randomized to receive 1gr/1v cephalotin (keflin) or equal volume of placebo 30min before incision. Patients were evaluated 1week, 2weeks and 12weeks after surgery by an independent surgeon or resident. Wound infection was defined according to the criteria of centers for Disease control and recorded. Results were assessed using chi-square and t-test as appropriate.

We included 282 patients in this study between March 2010 and october 2011. The total number of wound infection was 13 (4.7%), 4(2.8%) in antibiotic group and 9(6.4%) in placebo group (p= 0.29). There was 1 deep infection only in placebo group. Statistical analysis showed no significant difference in two groups.

The results show that, in Lichtenstein hernioplasty, routine use of prophylactic antibiotic is not indicated, as it does not significantly reduce the post operative surgical site infection rates.

Background and

Exposure to formaldehyde (FA), a highly-used chemical in industries, can induce serious health problems.Aim of this study was to explorethestatus of oxidant and antioxidant parameters in liver tissue of rats exposed to FAinhalation

Twenty-one male albino Wistar rats divided into 3 separate groups randomly (n=7). Rats in groups 1 and 2 were respectively exposed to atmospheres containing6 and 12 PPM FA continuously (8 hours/day, 14 days), whileanimals in group 3 which served as control group were not exposed to any stress source.The animals were anesthetized by CO2 and after decapitation, liver samples were collected and processed for estimation of MDA and GSHlevels in the supernatant by spectrophotometric methodin control and exposed groups. Data were analyzed bynonparametric tests and significance was expressedas P<0.05.

The present research findings showed statistically significant body weight loss in FA (12ppm) exposed group compared to the control and also FA (6ppm) exposed groups. However, a statistically significant decrease in liver weight and liver/body weight ratio was observed in the exposed groups compared to the control group (P<0.05). FA exposed groups showed a statistically significant decrease in GSH levelin liver tissue and statistically significant increase in MDA level in liver tissue (P<0.05). However, the levels of changes inbiochemical parametersin FA exposed groups were not dose-dependent.

The results of present study show that exposure to formaldehyde is toxic to liver tissue. Further research for exploring the toxicity of FA in occupationally exposed groups is recommended.