فصلنامه یافته
سال هجدهم شماره 3 (پیاپی 67، پاییز 1395)

Phenylketonuria (PKU) is a metabolic disease with autosomal recessive pattern of inheritance caused by a deficiency or absence of the enzyme phenylalanine hydroxylase in the liver. Phenylketonuria incidence is 1 in 10¡000 births. This study aimed to determine the epidemiological characteristics of phenylketonuria in Lorestan province.
All 81 phenylketonuria patients known in Lorestan province up to winter 2014 were considered in this descriptive epidemiologic study. Based on the goals and variables of the study¡ a complete questionnaire was developed to collect data through interviews with parents and the records and they were analyzed by use of SPSS v.16 software with preparing tables and graphs and using chi-square and t-test.
Results showed that phenylketonuria prevalence is 4.3 out of 100¡000 people in Lorestan province. Twenty of the patients (24.7%) were identified through screening and 61 patients (75.3%) through other methods. Forty-six of the samples (56.8%) were female and 35 cases (43.2%) were male. Nearly 75% of PKU patients had a positive history of consanguinity marriage in their parents. The prevalence of the disease was significantly different from other cities.
Neonatal screening for phenylketonuria is necessary and should be done within 3-5 days of birth. In families with children suffering from PKU¡ prenatal diagnosis is necessary for other pregnancies.

In the last two decades the using of artificial intelligence models for correct operation of the water treatment plant and maintain the stability of systems in favorable conditions, much researches has been done in this area. These models to simulate the behavior of water treatment systems can be used as an effective tool and to be used in the prediction of plant performance. The aim of this study was to evaluate of Khorramabad wastewater treatment plant performance (WWTP) using artificial intelligence network (AIN).
In this study, by using the AIN-LM and underlying the quality parameters measured at the entrance of plant (T, PH, DO, BOD, COD, TSS, TDS, NO3, PO4), the corresponding three parameters BOD, COD and TSS in the output of wastewater treatment plant was predicted. Statistical indicators used in this study were R, MSE and the software Matlab and SPSS (test T-test), respectively.
Based on the results, BOD, COD and TSS, respectively, with a maximum R, 0/98, 0/91 and 0/92 for the train data and 0/5, 0/66 and 0/5 for the test data and minimum MSE, 3/5, 33/15 and 2/17 for the train data 11, 115 and 20/99 were predicted for the test data, and the results were acceptable. Also, by calculating the percent removal of pollutants in the output of plant was revealed that TSS had the maximum efficiency of pollutant removal in wastewater treatment plant and was equal to 87/68 %. Also, other amounts of pollutant were closed to TSS.
In this study, AIN-LM created a reliable tool for predicting the performance of Khorramabad wastewater treatment plant and could predict the quality of effluent on the basis of measured parameters. So, remove of pollutants through the results were obtained by using the AIN-LM network, showed that, it was a good model, so the observed data indicates that confirm of the performance this model, as well. Also, the reduction of qualitative values as standard values recommended by the DOE indicates that the relatively good performance of the WWTP.

The existence of OCD-like symptom in patients with opium addiction , , the lack of a coherent, and shows the necessity of this study. The aim of this research is to study of prevalence of obsessive-compulsive disorder in patients with opioid dependency that refer to the addiction clinics affiliated to the lorestan university of medical sciences.
This research is a cross-sectional descriptive study. In this study, 200 patients with opioid dependency who attended to the addiction clinics affiliated to the Lorestan University of Medical Science were selected by convenience sampling method from December to February in 2013. Data collected by using instruments including Demographic Questionnaire and Zohar-fineberg screening questionnaire obsession. Descriptive and inferential statistical indicators by spss-20 software were used for data analysis.
In this study all participants were man. The mean and standard deviation of the respondents’ age and term drug abuse were in order 41/72±11/96 and 12/02±8/87. Patients were % 71 married, % 56 self-employed and in terms of education % 43 level of diploma. Also, 31 patients were with (% 15/05) obsessive-compulsive disorder and 169 patients were (% 84/5) without obsessive-compulsive disorder.
In creating drug abuse disorder, other disorders and symptoms may contribute and have important roles. Therefore, diagnosis and attention to it is important. Accordingly, clinical specialists on the results of such research design appropriate clinical trials or modify of existing interventions.

Given the large amount of gaseous and aerosol pollutants produced by the printing press industry, the indoor and outdoor air quality of such centers in Khorramabad, Iran was assessed.
Methods and Materials: In a descriptive study, five gaseous pollutants from among criteria air pollutants (CO, NO, NO2, SO2, O3) and volatile organic compounds (VOCs) were measured. Overall, 360 samples were taken from the indoor and outdoor air of printing press centers during the two seasons of summer and winter. In addition to the direct reading sampling method, environmental sampling was also conducted. In the direct reading method, the environmental analyzer device was used to measure criteria gaseous pollutants and the phocheck5000 device was used to measure the VOCs. In the sampling by environmental pumps, SKC activated carbon absorbent tubes were used randomly/continuously during the work hours and periodically for all centers. The samples were prepared using a carbon disulfide solution and were analyzed using a gas chromatograph device. Statistical t-tests were used to analyze the results.
The results of the study demonstrated that, the concentrations of the all of the criteria pollutants except for the CO gas and, among the VOCs, the concentrations of benzene and toluene in the air of the printing press centers was higher than the standards set by the EPA for indoor areas. Further, there was a significant difference between the concentrations of benzene and toluene during the summer and winder seasons (p Although printing press centers cannot be considered as serious hotspots for the emission of pollutants into public places in urban areas, the pollutants produced in these centers, especially O3 can jeopardize the health of the employees of these centers.

Diagnosis of Chronic myeloid leukemia (CML) is according to the existence of ABL_BCR fusions and Philadelphia chromosome. Various type of ABL_BCR fusions were studied on 58 cml patients.
Blood samples were obtained with informed consent after completing basic information. RNA was extracted from blood samples and cDNA was synthesized. By multiplex RT-PCR method, ABL-BCR fusions containing b3a2 and b2a2, e1a2 and b3a2 were studied.
From 58 patients, who were positive ABL_BCR fusion, 18 patients (30.5 %) with fusion b2a2, 37 patients (71/62%) have b3a2 fusion and three (08/3 percent) fusion's e1a2 respectively. In this study 25 men and 33 women participated. In contrast with other studies, women with (CML) had more population than men in this study.
The results of the ABL-BCR fusion in the Lorestan province (with the exception of higher prevalence in women) were same to the other studies in Iran and b3a2 fusion has the highest prevalence in the patients were studied.

Cytomegalovirus (CMV) infection is one of the most common causes of death in people with immune deficiency diseases such as: organ or tissue recipients, patients with HIV/AIDS and newborn infants. The aim of this study was to determine the prevalence of anti-CMV antibodies in patients with HIV/AIDS in the Kurdistan province.
This cross-sectional study carried out on 151 patients with HIV/AIDS covered by behavioral health counseling centers in Kurdistan province, 2015. For all patients the values of CMV antibodies, include IgG and IgM, were determined by ELISA technique and Diagnostic Kits (EIA WELL, Rome, Italy). Data analyses were done by use of t-test and multiple linear regression tests in stata software, version 13.
116 (76.8%) and 35 (23.2%) of the patients were male and female, respectively. Mean (SD) age of the patients were 39.3 (9.1) years. All studied patients were found positive for CMV-IgG (prevalence=100%), whereas only one case (0.7%) was found positive for CMV-IgM. The relationship between age and CMV-IgG levels was statistically significant.
The results showed that high prevalence of CMV in patients with HIV/AIDS, so in addition to paying more attention to the issue of HIV and CMV co-infection, about value of early antiretroviral treatment conducting further studies seems necessary.

Survey conducted by the center for disease control of the ministry of health shows that cases of AIDS through risky sexual behavior are increasing that could be warning for the intensification of the negative consequences of the disease in the community. Difficulty in emotion regulation and exposure to traumatic event are the most important factors in risky sexual behavior. The aim of this study was to investigate the mediating role of emotion regulation difficulty in the relationship between risky sexual behavior and exposure to traumatic events.
Two hundred substance abusers admitted to addiction treatment and recovery centers in Shiraz were selected by convenient sampling. To collect the data HIV Risky Sexual Behavior Scale (HRSB), Difficulty in Emotion Regulation Scale (DERS) and Life Event Checklist (LEC) were used. Possible causal model was analyzed by Structural Equation Model (SEM).
The results of this study support the mediating role of emotion regulation difficulties (β=0.31, P=0.0001) in the relationship between exposure to traumatic event and risky sexual behavior.
According to evidence, it can be concluded that exposure to traumatic event and difficulty in emotion regulation can provide risky sexual behavior. Furthermore, trauma by disrupting the emotion regulation can lead to risky behavior.

Salmonella enterica serotype Enteritidis is one of the most important cause of non-typhoidal ýsalmonellosis, a clinically less severe infection than typhoid fever. The present study aimed to ýdetection of virulence genes in the S. enteritidis isolated from the food samples by multiplex-PCR ýmethod.ý
In this descriptive cross-sectional study was performed during a year in 2014 on the 1250 no ýduplicative and non-repetitive food samples. M-PCR assay was done in order to detection of ýinvA ý¡ttrC¡ý mgtC¡ý spi4D and agfA genes.ý
Totally, sixty S. enteritidis strains were obtained from the poultry meat (38 strains, 61.6%) and ýthe eggs (23 strains, 38.3%), respectively. The highest and lowest prevalence of these genes were ýrelated to mgtC (51.6%) and spi4D (1.3%).ý
Evaluation of virulence genes in the S. Enteritidis isolated from food samples are useful because ýof the incidence of the virulence elements and efficiency of M-PCR in the epidemiological study ýand evaluation of intraspecies genes transfer in the various samples.ý

Diabetes mellitus is one of the prevalence metabolic disorders in the worldwide. Studies have shown that fruits, vegetables and drinks that are rich in phenolic and antioxidants components may reduce cardiovascular and diabetes diseases. One of these fruits is Pomegranate that is rich in phelavonoid. Therefore, this study was designed to determine pomegranate juice effect on fast blood sugar, lipid profile, anthropometry, total antioxidant capacity and blood pressure in diabetic patients.
In the present study, 50 patients with diabetes aged 30-50 were recruited into the study and randomly assigned into 2 groups:1) intervention group (n=25) that fed 240cc pomegranate juice daily, 2) control group (n=25) that fed 240cc water daily. Weight, hip circumstance, waist circumstance, lipid profile (HDL-C, LDL-C, TG, TC) glucose, HbA1C, GPX, total antioxidant capacity, systolic and diastolic blood pressure were measured at the baseline and end of 8 weeks.
Insulin resistance, systolic and diastolic blood pressure, body weight, hip circumstance, waist circumstance decreased significantly and GPX increased in intervention group whereas pomegranate juice had no significant effect on glucose, HbA1C, lipid profile and total antioxidant capacity.
These findings indicate that beneficial effect of pomegranate juice on insulin resistance, systolic and diastolic blood pressure, body weight, hip circumstance, waist circumstance, GPX

Obesity is a common problem for public health around the world, which are associated with the risk of developing various diseases. In order to improve treatment and appropriate intervention to combat this growing wave of obesity, identify significant factors in susceptibility to overweight and obesity is critical. Thus, the present research investigated the relationship between emotion regulation and eating behavior among women with high and normal body mass index.
The present study was causal-comparative where the population included women referring to hospitals and clinics in districts 1 and 2 in Tehran as well as women with normal weight living in these two districts. Among them, 150 women (75 overweight and 75 normal weights) were selected using convenience sampling. They were asked to complete Difficulties in Emotion Regulation Scale (DERS) and Three-Factor Eating Questionnaire (TFEQ). The data obtained were analyzed using independent t-test.
The results showed that non–acceptance of emotional responses, difficulties engaging in goal-directed behavior, impulse control difficulties, limited access to emotion regulation strategies, and total scores in emotion regulation, as well as emotional eating, and uncontrolled eating in obese individuals were significantly higher than those of normal weight. Conversely cognitive restraints in obese individuals were significantly less than those who had a normal weight.
Difficulty in emotion regulation and eating behavior can play an important role in obesity are requiring more attention.