مجله زنان مامائی و نازائی ایران
سال هجدهم شماره 165 (هفته سوم و چهارم مهر 1394)

Medicinal plants are an important source for treatment of various diseases. However، the possible toxicity of these plants on gestation needs to be evaluated before their clinical applications in pregnant women. Nigella sativa is one of the medicinal plants widely used in traditional medicine، however there is no enough evidence about its potential risks in pregnancy. This study was performed with aim to determine the potential toxicity of N. sativa seed extract on pregnant rats. This animal study was performed in 2015. In this study، pregnant rats were divided into three groups of eight cases: (1) control group which received regular food and water، (2) the group of N. sativa with low dose، from the beginning of pregnancy until the tenth day of pregnancy، 50 mg/kg of hydro-alcoholic extract of Nigella sativa was added to their oral water، and (3) the group of N. sativa with high dose، from the beginning of pregnancy until the tenth day of pregnancy، 300 mg/kg of hydro-alcoholic extract of Nigella sativa was added to their oral water. During pregnancy، the number of stillbirths and neonatal health status were assessed. Data analysis was performed using one-way ANOVA and Tukey''s post hoc test. Compared to control group، N. sativa extract at 50 mg/kg and 300 mg/kg had no significant effect on duration of pregnancy، percent of stillbirth، number of newborns، and weight of neonates. Also، no abnormal behavior and skeletal deformity were observed in neonates monitored for 30 days after birth. Consumption of hydroalcoholic extract of N. sativa up to 300 mg/kg during the first half of gestation has no toxic effect on pregnancy and newborns health parameters in rats. Further studies on the long-term side effects of N. sativa are recommended.

Women''s belief that health control to what extent is their own can serve as an internal motivation which causes preventive behavior of disease. This study was performed with aim to investigate the belief to the type of health locus of control and its relationship with women''s attitudes about breast cancer. This cross-sectional study was performed on 200 women with positive family history of breast cancer in Sabzevar at 2014. Data collection was performed by interview using Walston Health Locus of Control regional scale and researcher-made questionnaire. Belief in internal locus، belief to chance، and belief to other people were assessed. LISREL software (version 8. 8) was used for validity، and data analysis was performed by SPSS software (version 20)، and Correlation coefficient and stepwise multiple regression tests. In this study، highest score was related to belief to internal health locus of control (5. 15±0. 52)، and lowest score was related to belief to chance (3. 34±1. 18). Also، no statistically significant relationship was found between women''s attitude toward breast cancer and belief to internal health locus of control (P=0. 49)، belief to chance (P=-0. 88)، and belief to other people (P=0. 12). But، education (P=0. 005) and age (P=0. 028) had significant effect on attitude. Belief to internal health locus of control has not effect on the attitude of women with positive family history of breast cancer.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. Quality of life in women with polycystic ovary syndrome is lower compared to healthy subjects and even the patients with other gynecological diseases. This study was performed with aim to evaluate the effect of selected interval exercise on body composition and quality of life in students with polycystic ovary syndrome. This practical pretest-post test quasi-experimental study was performed on 10 non-athlete students diagnosed with PCOS in 2014-2015. The subjects performed selected interval exercise 3 sessions per week for 6 weeks. The participants were evaluated using women quality of life questionnaire and measurement of Anthropometric variables. Data was analyzed by SPSS software (version 18) and Kolmogorov-Smirnov and dependent t- test. P<0. 05 was considered significant. In this study، body weight (P=0. 040)، body mass index (P=0. 049) and body fat percent (P=0. 041) were significantly decreased after exercise. The data comparison showed a statistically significant difference in menstrual disorders (P=0. 001)، weight (P=0. 016)، emotional-excitement (P=0. 009)، and Total score of quality of life (p=0. 036) after the intervention. Performing interval exercise can be effective to improve the quality of life in women with polycystic ovary syndrome.