مجله دانشکده پزشکی دانشگاه علوم پزشکی مشهد
سال شصت و یکم شماره 2 (پیاپی 157، خرداد و تیر 1397)

Today, overweight and associated metabolic disorders have become one of the major health concerns. The purpose of the present study was to investigate the effect of rope skipping and supplementation of cumin cyminum L. on anthropometric, body composition, metabolic, antioxidant and inflammatory in overweight men.
In this clinical trial study, 40 overweight young men were randomly divided into four groups of control, exercise, supplementation and combination. The exercise group program included eight weeks of selected creeping training. The supplementation and combined groups consumed 2 caps of 25 mg cumin cyminul daily. Blood samples were taken after 10 to 12 hours of fasting before and after eight weeks.
The results showed that after 8 weeks, there was a significant difference between body weight values of all groups and control group (P≤0.05). Also, there was a significant difference between body fat, BMI, leptin and CRP in the training and combination groups. This difference was apparent in TAC values only in complementary and combination groups (P≤0.05).
According to the findings of this study, it can be concluded that the use of cranberries and cumin in reducing the amount of leptin and inflammatory agents and increasing total antioxidant capacity plays an important role in regulating the body weight of overweight men. Although it seems, cumin and creeping exercises creeping and cumin exercises each independently show significant impacts

Considering the increased illness caused by obesity, therapeutic methods for controlling or preventing obesity and overweight are interest to researchers. Meanwhile, the manipulation of appetite hormones by exercise has been studied as a low-risk factor in the health process.
Material and A total of 13 healthy women with overweight or obesity of grade one with an average age of 25 years and an average body mass of 31.23 kg / m2 participated in the study. The test session included 3 stages of blood collection (before the activity 30 minutes and two hours after the activity) to measure the acylated ghrelin (AG) and peptide YY3-36 (PYY 3-36), as well as seven stages of completion of the VAS questionnaire to measure appetite. Data were analyzed by SPSS software version 20 and using repeated analysis of variance and LSD post hoc test.
There was no significant difference between the AG and PYY 3-36 post-activity levels compared to baseline (P Changes in appetite hormones are not always associated with changes in appetite. Other factors contribute to the response of these hormones

Adverse drug reactions (ADRs) are one of the most important problems in all hospitalized patients. It is especially more common and problematical in cancer chemotherapy. In this study we tried to evaluate the incidence of ADRs associated with chemotherapeutic drugs in colorectal and gastric cancer patients in a teaching hospital.
Material and A prospective observational study was carried out on patients with colorectal or gastric cancer who referred to outpatient chemotherapy unit of Imam Reza Hospital, Mashhad, Iran, between July and December 2016. The identified ADRs were assessed for causality, severity and preventability.
Among 121 patients (67 with colorectal cancer and 54 with gastric cancer) followed during 251 and 249 chemotherapy courses respectively, in 182 and 249 courses ADRs occurred. All patients with gastric cancer experienced at least one ADR but 28.4% of patients with colorectal cancer passed their chemotherapy course without any adverse reaction. Gastrointestinal tract complication and neurologic problems were the most common ADRs in gastric and colorectal cancer patients, respectively. Nausea and vomiting was significantly more common in gastric cancer patients who received EOX regimen and also muscular weakness in patients who received FOLFOX regimen. The same correlation was found between neuropathy and FOLFOX IV regimen in patients with colorectal cancer.
Patients undergoing cancer chemotherapy have higher chances to develop ADRs. Those patients on chemotherapy should be strictly monitored for the early detection and prompt management of the ADR to prevent morbidity and mortality

Left ventricular filling pressure (LVFP) determination is a key step in predicting prognosis and making an appropriate therapeutic strategy, especially in patients with heart failure. Left cardiac catheterization allows an accurate and direct evaluation of some hemodynamic variables that estimate LVFP. But, since this method is not completely free from complications, several different methods, especially echocardiographic, were used in order to non invasively evaluate LVFP. The aim of this study was to determine the accuracy of E/E’ ratio in non-invasive prediction of LVFP in patients with different EF.
In this study, LVEDP was measured in cardiac catheterization for 50 patients with sinus rhythm under left ventricular catheterization. Also, the mean E/E’ ratio (early diastolic mitral inflow velocity to annular velocity) was measured by Doppler echocardiography in all patients. At the end, the relationship between echocardiographic measurements and cardiac catheterization measuring LVEDP was evaluated.
The mean age of patients was 57.71 ± 11.72 years and 37 (61.7%) were male. The mean E/E’ ratio was 11.06 ± 4.17 cm/s and the mean LVEDP was 12.9 ± 3.96 mm Hg. The Pearson correlation between E/E' ratio and LVEDP was 0.717 (p 55%, and the weakest correlation in the EF=35-44.
The results of this study show that the evaluation of left ventricular filling pressure using a non-invasive calculation of E/E’ ratio in echocardiography has high accuracy and can replaced and used instead of invasive methods

Uropathogenic Escherichia coli (UPEC) is one of the most prevalent microbial factor resulting in urinary system infections. Many of its serotypes with genetic variety contribute to these infections. The present study was done aiming at genetic classification of UPEC strains isolated from urinary system infections in Chahrmahal & Bakhtiari province, Iran.
A total of 67 isolates of UPEC from patients hospitalized in
hospitals of Chahrmahal & Bakhtiari were chosen and tested in ERIC-PCR.
The studied isolates had band pattern varying from 110-3100 bp which were classified to 15 subgroups in the resulting banding pattern with simple matching similarity coefficient in 91% similarity level. Except 100 proximity found in four cases, other isolates had 44.4-48.1% genetic proximity. Placement of the studied isolates in several subgroups showed the acceptable discrimination power of ERIC-PCR technique in genotyping/ E.coli and presence of various sources of contamination of urinary system with this pathogen.
ERIC-PCR is a simple, fast and low cost method for describing the genetic variety of different strains of E.coli including UPEC strains

heart failure (HF), a syndrome is described with fatigue and dyspnea. The patientis involved in decrease of physical and social and other aspects of health. The objective of this study was to test the effects of CoQ10 and exercise training (ET) on rest blood pressure (bp), heart rate (hr), double product (RPP) and quality of life (QOL) in patients.
In this study 4o patients were recruited and assigned to four groups: ET, coq10, ET 犊 and control, randomly. Patients in ET group perfomed exercise three times a week, (25 to 45 minutes) with 60 to 80% intensity of maximal (hr). According to the result of Borg test in every time, the intensity of exercise has been increased for the next time. The second group consumed 100 mg two times daily. The third group tried to do exercise and consumed coq10. Rest bp, hr and RPP (bp×hr) were measured, in addition patients completed questionnaire (QOL), before and after 8 weeks.
Paired T test showed that, (RPP) and (QOL) were increased and rest bp, hr decreased significantly in three interventional groups (P Consuming of coq10 and exercise training, especially integration of these two methods result in improvement of hemodynamic factors and QOL in patients

The motor function in patients with multiple sclerosis is restricted and doing exercise training and supplementation with coenzyme Q10 can be effective in improving this condition. The purpose of this research was to investigate the effect of 8 weeks of combined exercise training and supplementation of coenzyme Q10 on some motor function indexes in patients with multiple sclerosis.
In this semi-experimental study, 28 patients (16 men and 12 women; mean age = 37/71±7/18 years) with multiple sclerosis (EDSS=3-5) were selected using purposive sampling method and were evaluated into three experimental groups (combined exercise training䍝 supplement, combined exercise trainingꙖ鱹, Q10 supplement) and one control (placebo) group. The exercise training was done for 8 weeks (two sessions of resistance and one endurance session per week) and the dose of supplement of Q10 was 200 mg daily. Before and after intervention, the patients performed functional tests. Data were analyzed by statistical methods of covariance analysis, paired sample t-test and Bonferroni post-hoc test at a significant level of P The results of tests of analysis of covariance and paired sample t-test indicated significant reductions in the durations of functional tests of 25-foot walk and timed up and go and significant increases in the records of tests of chair stand and 6 minute walk in the training닪榕 and training groups compared to the supplement and control groups after the end of the intervention period (P= 0.0001); but there was no significant difference between the two training groups (P ≥ 0.05).
Accordingly, the patients with multiple sclerosis can use the provided combined training, with or without coenzyme Q10 supplementation, to improve their motor function. Also, coenzyme Q10 supplementation doesnt affect the improvement of motor function in these patients

Irisin is a myokine released from a membrane protein FNDC5 and has positive effects on carbohydrate metabolism. The aim of this study was to compare the effect of two different intensities of combined training on serum irisin, FBS, HbA1c and insulin resistance.
26 patients with type 2 diabetes mellitus were divided into 3 groups, intense and moderate combined exercise and control group. The training groups participated in combination exercises with high or moderate intensity for 8 weeks. Exercise aerobic moderate intensity performed with 70 to 89% of HRmax, 75 minutes per week. Addition 2 day strength training with elastic band. Moderate exercise aerobic exercises were performed at 55-69% of HRmax, 150 minutes per week. and resistance training two days a week with elastic band. Blood samples were taken before exercise and 48 hours after the last session.
Combined exercise leading to increased irisin, decrease fasting blood glucose, HbA1c, and decreased insulin resistance in both experimental groups (P Combined exercises are beneficial for increasing the level of irisin, reducing fasting blood glucose, HbA1c and decreasing insulin resistance, and therefore controlling diabetes. Moderate combination exercises can be used to improve glycemic conditions as an efficient method