مجله پزشکی دانشگاه علوم پزشکی تبریز
سال سی و هفتم شماره 5 (پیاپی 119، آذر و دی 1394)

Regular exercise expands capillary bed in active muscles which is mediated by several angiogenic factors. On the other hand, Ginseng is a herbal supplement that induces angiogenesis. The aim of this study was to investigate the effect of circuit resistance training combined with ginseng supplementation on serum Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF) in inactive females.

In this semi-experimental study Thirty-two healthy and inactive females (20-30years) were randomly divided into four homogenous groups first group received Training and Ginseng supplement (TG), group two received Training and Placebo (TP), group three received only Ginseng and group four only received placebo (P). The training groups received the circuit resistance training at the 65-75% of maximal intensity, 3 days a week for 6 weeks. Besides resistance training, subjects were given either ginseng (5 mg/kg per day) or placebo. before and 48 hours after interventions body composition was measured and blood samples were taken in order to assess serum levels of VEGF and PDGF. One-way ANOVA and Tukey post hoc test were used to analyze the data.

We observed that circuit resistance training with and without ginseng supplementation significantly increased serum levels of VEGF in inactive females (p<0.05) but ginseng supplementation alone had no significant effect on VEGF levels (p>0.05). Moreover, circuit resistance training by itself also had no significant effect on PDGF levels (p>0.05), but ginseng supplementation alone and in combination with resistance training decreased PDGF levels (p>0.05).

Circuit resistance training in a short period of 6 months may increase circulatory levels of antigenic factors such as VEGF but ginseng supplementation had no effect on antigenic factors. Nonetheless, further studies are warranted in this field.

Electro spinning is a method to produce the submicron nanofiber polymer in fibers produced by this technique have a unique feature in the medical field due to their high porosity and strength, Chitosan has been used as antimicrobial and healing properties, but because of its high viscosity it is unable to form nanofibers by it self. To overcome this problem, the polymers such PEO and PVE are used. Henna extract because of its ability to Boost the growth, antibacterial and healing properties were used to form nanofibers with the above polymers.

The solution of chitosan, polyethylene oxide and henna in ratio ranges of 40/60 up to 10/90 were prepared. Then stabilized on the cell culture medium and then after fibroblast cells were culture on it.

No significant difference was detected between nanofibers cell cultured compared to controls. As healing of burn or wound is the growth of fibroblast cell and inhabitation of wound infection. Thus nanofibers could potentially be used for ulcer healing and bacterial growth prevention. Thereby the chitosan and henna is a candidate because of its anti-bacterial and boost growth boosting effect.

As a result, Chitosan and henna as a candidate anti-bacterial and healing can be used.

Infertility in men is mainly caused by as low or abnormal spermatogenesis and hormonal problems. Because of high costs and potential side effect of routine therapeutic modalities. It seems that use of herbal medicine have fewer side effects; the aim of the study is to examine the effect of palm pollen extract on serum levels of hormones and spermatozoa dynastic cells in adult male mice.

This experimental study was conducted on 40 adult male rats. They were divided into 5 groups 8, in each group that included controls (no treatment), only saline treated and three experimental groups that received aqueous extract of date palm pollen in three different dosages, doses 100, 200 and 400 mg / kg respectively. All prescriptions were done intraperitoneally for 35 days. At the end of experiment animals were phlebotomized from the heart and by separation of serum samples, amounts of testosterone, estrogen, progesterone were counted, and by separation of testicle, the numbers of spermatogonia, spermatocytes and spermatid were counted and the results were analyzed using unilateral ANOVA and Duncan methods.

The results showed that aqueous extracts of palm pollen dose-dependently caused significant increasing the levels of estrogen, progesterone and testosterone and increasing the numbers of spermatocytes and spermatid.

The presence of compounds such as cadmium, zinc, steroids, flavonoids, saponins, lipids, and by substances that inhibiting the enzyme 5- alpha redoctase could increase testosterone and sexual dynastic cells.

Alzheimer's disease is a neurodegenerative disorder accompany with cognitive, behavioral and motoral abnormalities. Several factors affect this multifactorial disease. The most important factors in addition of genetic factors is general educational level of these patients. In this study, 50 patients with Alzheimer's disease were enrolled. After obtaining demographic characteristics including general educational level, alpha wave was analyzed in different lobes using Quantitative Electro Encephalography (QEEG) and Mini Mental State Examination (MMSE) test to determine the cognitive criteria. The mean age of patients was (71.5 ± 6.08 years, the MMSE mean score was (14.79 ± 5.08) and mean educational duration was three years. The QEEG study showed that absolute power of alpha wave has significant association with cognitive functions in different regions of brain (P≤0.05). The results showed; educational level, alpha of parietal and frontal lobes predicted and explained with %68 percission the changes of calculation function in the mal performance of patients with Alzheimer`s disease (P≤0.05). The general education level along with other causes of Alzheimer's disease plays an important role in the development of this disorder. People with higher level of education are less likely to develop the disease.

There are different anesthetic methods for hemodynamic stabilization during lumbar disc surgery. Anesthesias with intravenous drug including propofol-remifentanil and isoflurane have acceptable results inthis regard. In this study we compared the hemodynamic effects of these two anesthesia methods in patients, candidate for lumbar disc surgery.

In this study, 70 patients, who were candidate for lumbar disc surgery underwent general anesthesia using propofol-remifentanil or isoflurane. After induction with lidocaine, propofol and sisatracorium, anesthesia was maintained in isoflurane group with controlled respiration using oxygen and N2O with 50% ratio with isoflurane 1% and in propofol-remifentanil group, with controlled respiration using 100% oxygen with propofol 5 mg/kg/h and remifentanil 0.125 µg/kg/min. Hemodynamic findings during surgery and after surgery were recorded in both groups.

There were no significant differences between groups in their systolic and diastolic blood pressure, heart rate and oxygen saturation. Also, both groups were similar in their return to spontaneous breathing and extubation, time for eye opening and ability of verbal communication, meanwhile, frequency of general presentations such as chill, agitation, degree of post-surgery hypoxia. Nausea and vomiting were not significantly different between two groups.

Anesthesia with both methods; intravenous propofol-remifentanil or inhaled isoflurane in patients who are undergoing lumber disc surgery regarding to heir hemodynamic effects such as hypotension and brady cardia are acceptable.

Deep vein thrombosis is one of the most important complications in patients with spinal cord injury. The aim of this study was to compare the effects of mechanical prophylaxis with or without pharmacological prophylaxis on prevention of deep vein thrombosis in patients with spinal cord injury.

We conduct a double blind clinical trial study with 75 cases. These patients were divided in to three groups which matched by age and sex. In first group, compressive stocking with prophylactic dose of Enoxaparin (40mg daily) was implemented. For second group compressive stocking with prophylactic dose Heparin (5000 u bid SC) was the therapeutic strategy and for the third group only compressive stocking was applied. Collected data was analyzed by statistical methods.

The incidence rate of deep vein thrombosis in hospitalization period for the first group: %12, second group: % 4 and third group was %4. No statistical significant differences was detected between the results of these groups. (p=0.424)

Based on the results of our study, rate of deep vein thrombosis incidence is lower than the other studies. We didnt see any preferences between pharmacologic prophylaxis and mechanical methods on deep vein thrombosis preventive effects.

Recent advances in the field of intensive care have dramatically improved the survival of preterm born infants. The infants who born before 34 weeks of gestational age often have an immature or absent coordination sucking- swallowing and breathe pattern lead to feeding difficulties. In order to improve the efficacy of oral feeding in preterm infants, effective early interventions are needed. The purpose of current study is the effect of oral massage on physiological and behavioral indicators, frequency and duration of independent oral feeding in preterm infants.

In this study forty-Eight Preterm infants, between 28-32 weeks of gestational age who were hospitalized in NICU were randomly divided in two groups; oral massage group and controls. Newborns in oral massage group received, pri and intraoral massages, twice per day, each time for 10 minutes before gavages at least for 10 consecutive days. Outcomes have been assessed and recorded in both groups.

Duration and frequency of independent oral feeding that was assessed for 5 day was significant higher in massage group (p<0.001) (p>0.002). There was no difference in Oxygen saturation, heart rate and behavioral state during oral feeding between two groups.

Oral massage can increase both the duration and frequency of independent oral feedings in preterm infants. However it has no effect on physiological and behavioral parameters during independent oral feeding development.

Miller Fisher Syndrome is an uncommon variant of Guillain-Barre syndrome of then presents with clinical triad of ataxia, areflexia, and ophthalmoplegia. In this report, a 3 year old girl with acute ataxia and areflexia without physical sign of external ophtalmoplegia with sensory axonal neuropathy on electrophysiologic study is presented. Based on clinical and electrophysiologic findings, the diagnosis of Miller Fisher syndrome was made and the patient underwent treatment with intravenous immunoglobulin for five days. With relative resolution of ataxia.