مجله پزشکی دانشگاه علوم پزشکی تبریز
سال سی و چهارم شماره 3 (پیاپی 99، امرداد و شهریور 1391)

In spite of salt iodization program which began in Iran in 1989، there are controversies regarding the impact of iodine fortification in certain regions of the country such as West Azerbaijan province. The aim of the present study was to re-evaluate urinary iodine excretion and the prevalence of goiter during puberty in female schoolchildren aged 10-17 years in Urmia city.

In this cross-sectional study، 500 female schoolchildren aged 10-17 years were enrolled by random cluster sampling from schools in different educational areas in Urmia. The schoolchildren were classified into 3 groups according to the puberty status: group 1: prepuberty (n=61); group 2: puberty (n=354) and group 3: post puberty (n=85). Urine iodine excretion and prevalence of goiter was evaluated.

The median urinary iodine excretion in groups 1-3 was 125 µg/L، 142 µg/L، and 170 µg/L، respectively. Prevalence of goiter in groups 1-3 was 3. 3%، 14. 6% and 8. 3%، respectively. The prevalence of goiter between group 1 and group 2 was statistically significant (P=0. 03). A significant positive correlation was found between age and urinary iodine excretion (P=0. 008).

This study revealed that 77. 2% of the studied population was iodine sufficient. The highest prevalence of goiter was seen in schoolchildren at puberty (14. 6%) reflecting the high metabolic rate، hormonal alteration during puberty as well as nutritional factors in particularly the demand for higher iodine intake.

knee deformities associated with osteoarthrosis (OA) is a common presenting complaint in the orthopedic clinics. High tibial osteotomy (HTO) is an accepted procedure in the treatment of medial knee osteoarthritis with varus deformity. The methods for HTO include boths; open wedge osteotomy and closed wedge osteotomy. In this study compared the results of HTO with these two methods.

In a descriptive study، 32 patients with genu varus deformity (42 knee) were included. Patients were divided in two age and sex matched groups and treated with open wedge osteotomy or closed wedge osteotomy. Patients in both groups were followed for six month and the results of treatments were compared.

32 patients with genu varus deformity (10 cases (31. 2%) bilateral) including 25 (78. 2%) women and 7 (21. 8%) men were studied. Incidence of main complication after open wedge and closed wedge osteotomy were similarly (12. 5%). The main complication in open wedge was intraarticular fracture and in closed wedge was peroneal nerve Paralysis. There were significant difference in operation time، time of weight bearing and return to daily activities between two groups (p<0. 001). The varus correction angle، the Lysholm and the Tegner Activity score and Insall Salvati Index were not significanty different between two groups. Overall patient’s satisfaction in open wedge surgery was 87. 5% and in closed wedge was 75%.

Results of this study revealed that clinical outcome of patients in open and closed wedged surgery were not different and both methods are successful. However open wedge osteotomy has less neurological complications and higher patient’s satisfaction.

Ulcerative colitis (UC) and Crohn’s disease (CD) are immune mediated disorders of the intestine. Irritable bowel syndrome (IBS) is a functional، multifactorial disease. Several lines of evidence support the hypothesis that a low-grade mucosal inflammatory process may play a role in IBS pathogenesis. In this study we evaluated T cell population in colonic mucosa of IBS and IBD patients.

In analytical descriptive study، 83 patients including 35 patients with ulcerative colitis and 48 patients with IBS compared with 37 healthy volunteers. Tissue samples was tacked by colonic biopsy during colonoscopy and evaluated by histological and Immunohistochemistry (IHC) ways.

Thirty five patients with ulcerative colitis and 48 patients with IBS and 37 samples in patient who were underwent colonoscopy for another reason and they had normal results were also studied. CD4+ and CD8+ T population in IBS patients with similar to healthy volunteers and their ratio were not difference between them but in ulcerative colitis CD4+ T cell counts and ratio of CD4+/CD8+ were significantly higher than healthy volunteer (p<0. 001) and CD8+ counts were lower in comparison of IBS and healthy volunteer (p<0. 001).

Results of this study revealed that a CD4+ and CD8+ T cells infiltration does not have an important role in IBS mucosal immunity dysfunction.