فهرست مطالب

Hormozgan Medical Journal
Volume:22 Issue: 1, Jan-Mar 2018

  • تاریخ انتشار: 1396/12/20
  • تعداد عناوین: 8
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  • Golnaz Arbab, Seyed Alireza Sobhani *, Mohammad Reza Kordi, Abbas Ali Gaeini Pages 1-11
    Introduction
    Chronic vascular inflammatory state plays an important role in the pathophysiology of thalassemia. Cross-sectional studies suggest that exercise has anti-inflammatory effects, leading to lower levels of several proatherogenic inflammatory markers. However, this has yet to be confirmed by randomized prospective trials. The present pilot study examined the effect of Concurrent) Training on inflammatory markers of Beta Thalassemia Major Patients.
    Methods
    In this semi-experimental study, 18 patients with Beta Thalassemia major were selected as convenient samples and voluntarily divided in two groups: experimental (n=9) and control group (n=9). The subjects of the experimental group attended the concurrent (Resistance-Endurance) Training for eight weeks (3 Sessions per week and each sessions 90 min). Subject's blood samples were taken before and after training protocol in order to measurement hs-CRP, IL-6, IL-1ᵦ andIL-12 Serum levels. The levels of these markers were measured by using an enzyme-linked Electro immune assay (ELISA) kits. For data analysis the Repeated measures ANOVA, was used. All statistical analysis was performed by SPSS software (V.19). The level of significance was considered P
    Results
    The results indicated reduction of HS-CRP and IL-6 after eight weeks of concurrent training compared to the control group (P
    Conclusion
    The reduction of HS-CRP and IL-6serum level and its natural range in the exercise protocol, can be a regulating response to inflammatory condition in patients under certain exercise conditions without any pathological importance and maybe improved chronic vascular inflammation. We demonstrated that concurrent (resistance-endurance) training is inversely correlated with levels of pro-inflammatory markers in Beta Thalassemia major patients, possibly retarding the process of atherosclerosis andresults showed that immune modulation.
    Keywords: Concurrent Training, Beta Thalassemia Major, Inflammatory Markers
  • Shadan Saberi, Mehdi Nematbakhsh, Aghdas Dehghani * Pages 12-17
    Introduction
    The angiotensin 1-7 (Ang1-7) Mas receptor (MasR) axis, bradykinin (BK) and female sex hormone are involved in releasing of vasodilatory biomarkers including Nitric Oxide (NO). We examined the role of MasR and BK on NO metabolite (nitrite) production response to Ang 1-7 infusion in ovariectomized rats treated with estradiol.
    Methods
    A total of 48 female Wistar rats were divided into 2 main groups; ovariectomized treated with placebo (OVX) and ovariectomized treated with estradiol valerate (OVE) for period of two weeks. Then after anesthetization, the animals of each groups were divided into four subgroups that received MasR antagonist (A779) or , BK, BKξ or vehicle, and they were subjected to Ang1-7 infusion (0, 100, 300 and 1000 ng/kg/min). The level of nitrite (NO metabolite) was measured by Griess method.
    Results
    The serum level of nitrite response to Ang 1-7 administration in OVE group was incrased when compared with OVX group, however when MasR was blocked by A799, the increased nitrite level was abolished. BK also increased the level of nitrite but co administration of BK and A779 did not enhance the nitrite level in both OVE and OVX groups.
    Conclusion
    Estradiol and Bk increase nitrite production in response to Ang 1-7 infusion in condition of MasR presence.
    Keywords: Angiotensin 1-7, Mas Receptor, Nitric Oxide, Bradykinin, Rat
  • Maryam Abbasi Darehbidi, Effat Bambaeichi, Mehdi Nematbakhsh * Pages 18-24
    Introduction
    The production of Reaction Oxygen Species (ROS), lowers cellular antioxidant levels, and enhances oxidative stress in many tissues, especially the liver. Efficient liver function is extremely important to the overall health. The key to helping prevent long-term damage is to decrease oxidative stress. The purpose of this study was to assess the effects of treadmill training with vitamin C or estradiol on nitric oxide metabolite, oxidative stress marker and liver enzymes levels in female rat.
    Methods
    Thirty two female rats were randomly divided into four groups of 8 rats each; consisting of control (Con), training (Tr), training vitamin C (Tr嘫), and training立歩� (Tr) groups. Vitamin C (250 mg/kg/day) was injected three times a week for 6 weeks, and estradiol (0.25 mg/kg/week) was injected for the two first weeks. Training groups performed aerobic exercise on a treadmill 5 days/week for 6 weeks. Serum and liver tissue levels of nitrite and malondialdehyde (MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum were determined.
    Results
    The results showed significant reductions in the serum nitrite in Tr嘫 group (6.33±0.37µmole/l) compared with Con group (9.67± 1.39 µmole/l) and Tr group (9.91± 1.33 µmole/l) groups. While Tr group (0.22±0.02 µmole/l) exhibited lower liver nitrite compared with Con group (0.29±0.01 µmole/l) group. Serum MDA in Tr (6.68±0.31 µmole/l) and Tr嘫 (7.01±0.44 µmole/l) groups was significantly higher than in Con groups (5.20± 0.40 µmole/l).
    Conclusion
    Our findings indicate that the treadmill training program used in this study was able to attenuate the liver oxidative stress but administration of vitamin C or estradiol couldn’t improve liver status.
    Keywords: Estradiol, Oxidative Stress, Nitrite, Liver, Rat
  • Seyed Abdolvahab Taghavi, Najmeh Tehranian, Reza Jamhiri, Shahintaj Aramesh, Mina Mosadegh, Zahra Rezaee, Hedyeh Bahraini, Nasibeh Rozbeh, Fatemeh Bazarganipour * Pages 25-32
    Introduction
    Gestational diabetes is a common problem in pregnancy that affects about 7% of pregnancies. The high intake of iron intake is associated with an increased risk of type 2 diabetes in the general population. The purpose of this study was to determine the association between total iron intake (diet and supplement) and gestational diabetes.
    Methods
    This is a one-year prospective cohort study. 120 pregnant women referred to rural health centers in Bandar Abbas, Hormozgan, Iran were enrolled in the study. The data were collected using a checklist, food frequency questionnaire (FFQ) questionnaire for measurement of iron intake through food. Demographic data was presented as mean±SD or number (%) and final results were presented with Odds Ratio (OR) with 95% confidence interval.
    Results
    The findings showed that hemoglobin level in 6-10 (OR: 2.62 CI: 1.42-4.39) and 24 to 28 weeks (OR: 2.9 CI: 1.43-4.02), the amount of iron intake from the beginning of the pregnancy from 6 to 10 (OR: 2.81 CI: 1.28-3.98) and 16-20 weeks of pregnancy (OR: 2.94 CI: 1.35-5.43) as well as, the amount of iron supplemental ingestion (OR: 2.83 CI: 1.39-4.54) are the most important predictors of GDM.
    Conclusion
    According to the findings of this study and the current national guidelines for the administration of routine iron to all pregnant women, increasing the level of iron by supplement and subsequent increased risk of GDM should be more considered.
    Keywords: Hemoglobin, Iron, Gestational diabetes, Cohort
  • Maryam Moradi, Mona Roozbehani, Jebreil Shamseddin*, Hamid Reza Hashemi Pages 33-37
    Introduction
    Parasitic diseases and infections remain a significant cause of morbidity and mortality in the developing countries all over the world. Gaining data about parasitic infection is necessary to contrive suitable control programs and strategies to prevention and that is main aim of this study. This study evaluated frequency of intestinal parasites in Milad hospital, Tehran, Iran.
    Methods
    During 2015-2016 about 13385 stools and 343 scotch tape samples were collected in Tehran. All specimens examined by direct smear and formalin- ethyl acetate concentration methods. All stool samples were well analyzed to diagnose any proglottids or mature helminthes that can be seen in stool in some conditions. Scotch tape method is an appropriate way to detect parasitic nematode of Enterobious vermicularis.
    Results
    Data showed that 2.7% of cases had at least one parasite in examination. Frequency of parasites reported as B.hominis (1.3%), G.lamblia (0.8%), E.nana (0.3%), E.coli (0.3%), Taenia and C.mesnili (0.1%, 0.1%). Six cases of 343 scotch tape samples were positive for pinworm.
    Conclusion
    Due to high standards of public health in Tehran, frequency of intestinal parasites is lower than other studies conducted in other regions. Demographic, socioeconomic characteristics and education can affect transmission of parasites and may involve in lifecycle completion.
    Keywords: Frequency, Intestinal Parasitic Disease, Iran
  • Arash Nademi, Elham Shafiei *, Esmaeil Fakharian, Abdollah Omidi Pages 38-44
    Introduction
    In Processes Modeling, when there is relatively a high correlation between covariates, multicollinearity is created, and it leads to reduction in model's efficiency. In this study, by using principle component analysis, modification of the effect of multicolinearity in Artificial Neural Network (ANN) and Logistic Regression (LR) has been studied. Also, the effect of multicolinearity on the accuracy of prediction of mental disorders after trauma in patients with Mild Traumatic Brain Injury has been investigated.
    Methods
    In a prospective cohort Study, first, during 6 months period, 100 patients with Mild Traumatic Brain Injury have been selected .Then, by using Primary Covariates and Principle Component Analysis, Logistic Regression and ANN models have been conducted and based on these models prediction have been done. (Receiver Operating Characteristic) ROC curve and Accuracy Rate have been used to compare the strength of model’s prediction.
    Results
    The results revealed that Accuracy Rate for ANN before and after applying principle component analysis are 84.22 and 91.23% respectively, and for Logistic Regression models are 72.33% and 74.89% respectively.
    Conclusion
    The study showed that the Accuracy Rate was higher for models based on Principle Component Analysis including primary covariates; hence, when multicolinearity exists, models that use the principle component for prediction of mental disorders are more effective compare to other methods. Also, ANN Models are more effective than Regression models.
    Keywords: Traumatic, Brain Injury, Mental disorder, Logistic Regression
  • Ali Javadzadeh, Anousheh Haghighi, Farshad Naserifar, Mohsen Arabi, Atefeh Ghanbari, Nahid Kianmehr * Pages 45-51
    Introduction
    Rheumatoid arthritis (RA) is a chronic rheumatologic disease, affecting different aspects of patient life. Although several studies have reported a higher rate of depression among patients with RA, there is still controversy over the underlying risk factors and probable covariates of depression in these individuals. The present study investigated the relationship between disease activity, serum levels of vitamin D, and depression in patients with RA.
    Methods
    In this cross sectional study patients with confirmed RA based on the American College of Rheumatology guidelines entered the study. Disease activity was measured using the Disease Activity Score (DAS). The Hospital Anxiety and Depression Scale (HADS) was also administered to determine the subjects’ level of depression. The Health Assessment Questionnaire (HAQ) was applied for evaluating the subjective disability of the patients in their daily activities. Serum levels of vitamin D, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were also measured.
    Results
    62 patients were enrolled in the study. Depression was present and possibly present in 12 (19.4%) and 15 (24.2%) cases, respectively. According to the results the DAS was inversely associated with vitamin D3 levels (P
    Conclusion
    Higher scores on the HADS were directly associated with lower levels of vitamin D, HAQ score anddisease activity. Nevertheless, no significant association was found with HADS and patients’ sociodemographic characteristics.Targeted approach to psychological aspects and vitamin D levels among patients with RA may have considerable implication for the optimal management of RA.
    Keywords: Rheumatoid Arthritis, Depression, Vitamin D
  • Behzad Shalchi, Masoumeh Esmaeili Shahna * Pages 52-61
    Introduction
    Depression is considered as a disorder that students have a susceptible environment for it and is affected by many factors. Therefore, the purpose of this study was to determine the role of satisfaction of basic psychological needs and family functioning by interdisciplinary role of emotion regulation difficulty in the prediction of depression.
    Methods
    The method used in the study is descriptive approach by structural equation modeling. The sample consisted of 452 (207 boys and 245 girls) students universities Tabriz who were selected using multistage cluster sampling. Then, they filled out depression Questionnaire, satisfaction of basic psychological needs, family Assessment Device and Difficulties in Emotional Regulation Scale. Data were analyzed by using Pearson correlation coefficient, cronbach alpha and structural equation modeling.
    Results
    The results of the study showed that the goodness of fit index (GFI), adjusted goodness of fit index (AGFI), comparative fit index (CFI), is greater than 0.90 and root mean square error of approximation (RMSEA), and root mean square residual (RMR) index is less than 0.05. Therefore, the proposed model has had a very suitable fitness with data. In this study, the most direct effect is the satisfaction of basic psychological needs on depression with a coefficient of -0.38 and satisfaction of basic psychological needs has the most indirect effect through emotion regulation difficulty on depression with a coefficient of -0.12.
    Conclusion
    Based on the results of the present study, it can be concluded that Difficulties in Emotional Regulation As a Mediator of the Relationship between satisfaction of basic psychological needs and family function can explain depression in College Students and, thereby, attention to this matter can lead to the proposal of some recommendations for depression in College Students prevention and treatment.
    Keywords: Psychological Disorder, Emotional Regulation, Depression