مجله دانشگاه علوم پزشکی رفسنجان
سال پانزدهم شماره 1 (پیاپی 84، فروردین 1395)

Aflatoxin B1 is the most toxigenic aflatoxin and one of the most liver carcinogenic agent produced by some of the Aspergillus species. Successful control of this mold growth would be an important step in the prevention of cancer. This study was carried out for evaluating the effect of isolated Lactobacillus acidophilus and Lactobacillus brevis on growth of Aspergillus flavus and reduction of aflatoxin B1.
In this laboratory study conducted in 2014, after identification of lactic acid bacteria (LAB) isolated from a traditional sourdough using polymerase chain reaction, the effect of these isolates on growth of Aspergillus flavus and reduction of aflatoxin B1 was studied by direct competitive ELISA. The effects of incubation time and heat treatment on residue of aflatoxin B1 in present of mentioned isolated LAB were also determined. Results were analysed by using t-test and one way ANOVA followed by LSD test.
After incubation period, the diameter of Aspergills flavus colonies in present of Lactobacillus acidophilus, Lactobacillus brevis and control sample were 1.50, 3.46 and 9.00 cm, respectively. The amount of aflatoxin B1 residue, after 0, 24 and 48 h incubation in present of Lactobacillus acidophilus were 50.60%, 48.93%, 41.24% and in present of Lactobacillus brevis were also 66.26%, 64.40% and 55.61%, respectively. Furthermore, non-viable cells of mentioned isolated LAB reduced the amount of aflatoxin B1, more effective than their viable cells (P By considering the high potential of LAB studied in this project for growth control of Aspergillus flavus and reduction of aflatoxin B1, it is possible to use their biopreservative ability for reduction of cancer risk.

Aerobic exercise or cardio is defined as a physical exercise that causes high oxygen consumption compared to the rest and conducted to increased cardiorespiratory intensity. Different substances, can inhibit pain occurred through opioids, histaminergic, and cholinergic receptors. This study was done to determine the role of aerobic exercise in pain by histamine receptors using formalin test in mice.
In this experimental study, by use of formalin test, the analgesic effect has been used in three groups of control, test one and test two and by ranitidine which is a histamine receptores inhibitor, the analgesic effect of aerobic exercise and the role of histamine receptors were investigated. For this purpose by use of mean score of pain and two way Anova and repeated major in every 5 minute; regarding, formalin test, as a standard pain inducing, was used.
Our result indicated that subcoutanous injection of formalin to the paw of the animal significantly(P The analgesic effects of aerobic exercise may be induced by histamine receptors.

There are some indices for scientometrics including counting the number of scientific publications and the number of citations to these publications. Hirsch Index(H-index)is widely accepted for scientometrics because it has both qualitative and quantitative components for scientometrics. This study evaluated the scientific outputs of faculty members of Rafsanjan University of Medical Sciences through measuring the H-index.
In this cross- sectional study the publications of 160 faculty members of Rafsanjan medical science university were evaluated. Number of articles and citations to these articles were collected through the Web of science and Scopus databases. Data were analyzed using one-way repeated measures ANOVA, followed by Tukey's multiple comparisons test & t-test.
The H-index mean values in this university were 1.27±0.2 (evaluated through Scopus database) and 0.9±0.1 (evaluated through Web of Science database).This index was higher for medical school faculty members compared to the other schools (p These findings demonstrated that H-index value for faculty members in this university was lower than the international standard. In addition, the H-index value was lower in Nursing and Midwifery faculty and also in Dentistry faculty compared to the medical faculty.It is recommended to improve H-index of faculty members of these schools by planning training courses in scientific researches and publications.

The dyestuff manufacturing and textile industries consume a high volume of water and produce a great amount of wastewater containing various toxic substances. Removal of dyes from water by absorption processes has received considerable attention. In the present study, removal of Acid orange7 from aqueous solution using the mesoporous (Mobil Composition of Matter No-41) MCM-41 silica functionalized by diamine group (NH2- MCM-41) was investigated.
This experimental study was done in samples of synthetic and real wastewater from Kerman Kavir baf Sarir factory within six months. In the first place, the nanoporous MCM-41 silica absorbeut was syn the sized and, then it was functionalized by diamine groups. The influence of pH, absorbent amount and time on the removal of Acid orange 7 was evaluated. Then, the optimal conditions for each of these parameters were determined. The same experiments were done for samples of real wastewater. In order to understand the process of absorption, kinetics of absorption isotherms equilibrium was also studied. SPSS software and regression were used to analyze the data.
The highest percentage of Acid orange 7 absorption was observed at pH=4, Retention time of 60Minutes, absorbent amount of 10g/L for synthetic solution with removal efficiency of 82% and for actual solution with the efficiency of 79%. Acid orange 7 dye with density of 60 ml/L resulted in at most 78% removal rate in the real solution.The findings revealed that the removal of Acid orange 7 followed the freundlich isotherm (R2=99%) and the second order synthetic model (R2=98%).
The results showed that the NH2-MCM-41 materials are effective absorbents for the dye removal from textile wastewater, especially AO7 dye.

Neuropathy is a state that resultes from nervous system disease or injury and exposes patients to the various functional complications such as decreased physical activity and its complication such as muscular and cardiovascular diseases. The purpose of the present study was determining the chronic effect of decreased activity by spinal nerve ligation (SNL) on Trk neurotrophin receptors gene expression in sciatic nerve fiber of male rats.
The present study was an experimental research in which ten neuropathic adult male wistar rats in the weight range of 250±20 were randomly divided into two groups including control and SNL. Over six weeks, neuropathic pain behavior tests conducted continually in the two groups. At the end of the sixth week, changes of TrkA, TrkC and TrkB gene expressions in sciatic nerve were measured with Real time PCR technique. The changes in gene expressions were measured with 2- ΔΔCT and were analyzed using independent t-test in the two groups. In order to compare the results of the behavioral tests in the two groups, two-way repeated measures ANOVA was performed.
The behavioral tests demonstrated that decreased activity in the SNL group induced mechanical allodynia and thermal hyperalgesia as well as decreased pain threshold (p The results revealed that decreased activity in the form of SNL was associated with the increased TrkA, TrkB and TrkC gene expressions. Also, it seemed that these neurotrophin receptors changed by neural injury. Although, the precise mechanisms were not well understood.

Today, understanding of systematic reviews and meta-analyses and their practical use is essential for who concerned with society's health. Most of the medical reports invoked to these reviews and statements and it is necessary for scientific experts to be familiar with their performing rules and the way of their writing. The basic sciences specialists and clinical professionals study them to keep up the level of their knowledge on the fields of interest.These articles are often seen as the beginning of the developing clinical guidelines for organizations that provide facilities to carry out a research and it is used to verify and justify further investigation. Some of the journals in the field of health adjust their publishing to this direction. Like other researches, Value of the systematic reviews and meta-analyses of the literature is to answer three questions: 1- what has been done? 2- what has been proven? and, 3- how has been it arranged? Systematic review and meta-analysis of basic sciences and clinical medicine could manage the problems of health system and formulate the guidelines for the collection and conclusions of the completed research, which is contributed to a specific subject or question. Iran is in the position of nineteenth among leading countries in publishing scientific journals related to review and meta-analysis articles. Guidelines developed at the PRISMA; Preferred Reporting Items for Systematic Reviews and Meta-Analyses, included a checklist and a flow chart. Therefore, the present study aimed to inform the Persian language researchers to publish their writing according to PRISMA statement.

Leadership style of head-nurses and clinical competency of nurses have a crucial role in developing of healthcare services quality. Recent studies showed differences between leadership styles and clinical competency of nurses in public and private hospitals. Therefore , this study aimed to assess leadership styles of head-nurses and clinical competency of nurses in public and private hospitals of Ahvaz.
This cross-sectional study was conducted on 67 head-nurses and 335 nurses in public and private hospitals of Ahvaz during 2014. Head-nurses and nurses were selected through census and systemic sampling methods, respectively. Data was collected by Burdens & Metzcus Leadership Behavior questionnaire and Meretoja questionnaire, and was analyzed using chi-square test and independent t-test.
Most of the head-nurses in the public (%52.9) and private (%57.5) hospitals had relationship-oriented leadership style, and no significant difference was observed between leadership styles of the head-nurses in the two kinds of the hospitals (p=0.703). The nurses in the private hospitals (125.32±8.41) had significantly higher clinical competency compared to the nurses in the public hospitals (118.22±9.51) (p=0.002).
The results showed more clinical competency in the nurses of the private hospitals compared to the public hospitals. Due to scanty of studies in this regard, further investigations are recommended.

In recent years Infant Mortality Rate )IMR) has been decreased in the developed countries but this rate is still high in the developing countries. This study aimed to investigate the causes of neonatal mortality.
This descriptive-cross-sectional study was performed on 110 hospitalized neonatal in NICU of Amiralmomenin Educational Hospital of Zabol University of medical sciences. Neonatal Mortality’s Questionnaire was used to collect the data. For data analysis, descriptive statistics was used.
The most common causes of mortality were prematurity and low birth weight.
Special care for premature and low birth weight infant and strengthening health care programs and emphasizing the need to identify high risk groups should be the priorities in decreasing the rate of neonatal mortality.