فهرست مطالب
Journal of Research in Medical Sciences
Volume:22 Issue: 12, Dec 2017
- تاریخ انتشار: 1396/10/30
- تعداد عناوین: 8
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Page 1BackgroundReading disorder (RD) is one of the important complaints in children with learning disorders (LD) that is prevalent in 4% of children in the United States. Treating this disorder includes education of reading practices and treating psychological disorders, and there are no exact medications prescribed in these children. Memantine has been e?ective in treating memory problems in Alzheimer Dementia, obsessivecompulsive disorder, autism disorder, and other psychological diseases. Te aim of this study is to evaluate the e?ect of memantine in improving RD in children.Materials And MethodsIn this randomized clinical trial, 62 children, with RD in Pediatric Psychiatry Clinics of Noor and Ali-Asghar Hospital in Isfahan from 2015 to 2016, were participated. Tey were randomly assigned to two groups of equal number, one receiving education plus memantine and the other education plus placebo. RD was evaluated at the beginning, 1 and 3 months after intervention by Iranian standard reading and dyslexia test(Nama).ResultsMean (standard deviation) age of participants was 7.55 (0.60) years. Most of the participants were boy (55%), most having parents in 3645-year-old age group (52% and 48% for fathers and mothers, respectively), and also most parents in diploma and bachelor educational group (61% and 60% for fathers and mothers, respectively). Tere were statistical signifcant di?erence in trend of total score (P = 0.034), word chain (PConclusionAdding memantine to educational practices is e?ective in improving RD in school-age children with LD.Keywords: Dyslexia, learning disorder, memantine
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Page 2BackgroundFuzzy logistic regression model can be used for determining in?uential factors of disease. Tis study explores the important factors of actual predictive survival factors of breast cancers patients.Materials And MethodsWe used breast cancer data which collected by cancer registry of Kerman University of Medical Sciences during the period of 20002007. Te variables such as morphology, grade, age, and treatments (surgery, radiotherapy, and chemotherapy) were applied in the fuzzy logistic regression model. Performance of model was determined in terms of mean degree of membership (MDM).ResultsTe study results showed that almost 41% of patients were in neoplasm and malignant group and more than two?third of them were still alive after 5?year follow?up. Based on the fuzzy logistic model, the most important factors in?uencing survival were chemotherapy, morphology, and radiotherapy, respectively. Furthermore, the MDM criteria show that the fuzzy logistic regression have a good ft on the data (MDM = 0.86).ConclusionFuzzy logistic regression model showed that chemotherapy is more important than radiotherapy in survival of patients with breast cancer. In addition, another ability of this model is calculating possibilistic odds of survival in cancer patients. Te results of this study can be applied in clinical research. Furthermore, there are few studies which applied the fuzzy logistic models. Furthermore, we recommend using this model in various research areas.Keywords: Breast cancer, fuzzy logistic regression, mean degree of membership, survival
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Page 3BackgroundRapid and accurate identification and evaluation of antifungal susceptibility pattern of Candida isolates are crucial to determine suitable antifungal drugs for the treatment of patients with vulvovaginitis candidiasis.Materials And MethodsVaginal samples were collected from 150 women with suspicious vaginal candidiasis, and then cultured on Sabouraouds Dextrose Agar with chloramphenicol to isolate Candida species. After identification of Candida isolates using polymerase chain reaction?restriction fragment length polymorphism technique, antifungal susceptibility testing of four azolic antifungal drugs was carried out using broth microdilution method according to the CLSI M27?A3.ResultsCandida species were isolated from eighty suspected patients (61.79%). The most common pathogen was Candida albicans (63.75%). Resistance to fluconazole and ketoconazole was observed in 27.5% and 23.75% of Candida isolates, respectively, and only 2% of Candida isolates were resistant to miconazole. Interestingly, resistance to fluconazole in C. albicans was more than other Candida species.ConclusionThe results indicated that therapy should be selected according to the antifungal susceptibility tests for the prevention of treatment failure and miconazole therapy can be considered as the best therapeutic choice in the
management of vulvovaginitis.Keywords: Azolic antifungal drugs, Candida species, polymerase chain reaction?restriction fragment length polymorphism, vulvovaginitis candidiasis -
Page 4Breast cancer is the most common cancer in women around the world. So far, many attempts have been made to treat this disease, but few e?ective treatments have been discovered. In this work, we reviewed the related articles in the limited period of time, 20002016, through search in PubMed, Scopus database, Google Scholar, and psychology and psychiatry literature (PsycINFO). We selected the articles about the correlation of microRNAs (miRNAs) and breast cancer in the insight into therapeutic applicability from mentioned genetics research databases. Te miRNAs as an e?ective therapy for breast cancer was at the center of our attention. Hormone therapy and chemotherapy are two major methods that are being used frequently in breast cancer treatment. In the search for an e?ective therapy for breast cancer, miRNAs suggest a promising method of treatment. miRNAs are small, noncoding RNAs that can turn genes on or o? and can have critical roles in cancer treatment; therefore, in the near future, usage of these biological molecules in breast cancer treatment can be considered a weapon against most common cancer?related concerns in women. Here, we discuss miRNAs and their roles in various aspects of breast cancer treatment to help fnd an alternative and e?ective way to treat or even cure this preventable disease.Keywords: Breast cancer, chemotherapy, hormone therapy, microRNA, treatment
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Page 5ardiotoxicity is one of the most feared side e?ects of chemotherapy with enhanced morbidity and mortality in survivors. Arrhythmia, heart failure, myocardial ischemia, hypertension, and thromboembolism are commonly reported as side e?ects. Hereby, we are reporting a case of severe mitral regurgitation as a complication of chemotherapyKeywords: Cardiotoxicity, chemotherapy, mitral regurgitation