مجله دانشگاه علوم پزشکی سبزوار
سال بیست و ششم شماره 1 (پیاپی 102، فروردین و اردیبهشت 1398)

 Cancer treatment is still one of the main challenges in the field of basic science and clinical science in medicine. Surgery is often the first option in the treatment of cancer, providing the tumor in a way that can be removed. Chemotherapy, radiation therapy, or a combination of both can be used to reduce the tumor in the pre- or post-surgical stage. Hormone therapy, stem cell and bone marrow cell transplantation, and immunotherapy are among other therapeutic approaches. Immunotherapy or the use of the immune system for treatment, after chemotherapy and radiation therapy is one of the most important complementary and effective methods for treating cancer. Immunotherapy such as chemotherapy is systematically done and used to prevent the spread of malignancies, but unlike that only attacks malignant cells and does not effect on normal cells. Cancer, immune therapy with the direct use of immune system components and makes an active immune response such as stimulating the patient's immune system cells and reintroducing these cells to the individual. Indirect stimulation and the use of immune products such as anti-cancer monoclonal antibody to remove tumor antigens is called passive immune therapy. The results from clinical trials confirm the design of combined therapies for cancer treatment, which include a combination of various immune therapies along with chemotherapy or the combination of several therapeutic immunotherapy approaches. The goal of this review article is to concisely review some of the most important recent developments in cancer immunology and immunotherapy, and explain new insights into the mechanisms that underlie cancer immune evasion by which might lead to pathways for identifying novel treatments.

Universities and higher education institutions, as knowledge-based institutions, play a key role in the development of countries and their performance in different domains should be evaluated. Ranking is one of the tools for assessing the performance, competitiveness and success of universities. It is desirable to rank as one of the key missions of the higher education system, so that, with its implementation, we can see the change in the behavior of institutions on the path to the goals of the macro. In this paper, we identified the ranking indixes of the Northeast Universities of Medical Sciences, which extracted from 119 citations of the 27 original codes and categorized into 7 branches. For the ranking of the medical sciences university, the main functions were considered. Is taken to select appropriate criteria based on content analysis and the most important concepts of each criterion were introduced. The results show that the most influential codes of each criterion were standardization, training factors, governance index, research, quality development index.

Soil pollution with heavy metals can decrease Fe availability in human food chain in industrial regions. This research was done to investigation the quality of tomato grown in a soil treated with iron slag and its effect on human health. This research was done in 2016 in a greenhouse experiment in Arak province with 72 pots including: applying 0, 15 and 30 t ha-1 cow manure enriched with 0 and 10% (W/W) iron sludge in a Pb polluted soil (0, 600, 800 and 1000 mg Pb kg-1 soil). At the end of experiment, fruit Fe concentration was measured and Fe daily intake for 4 to 50 years group was calculated. Consumption of 80 g tomato which cultivated in soil treated with 30 t ha-1 enriched cow manure with iron slag can supply 18.4% Fe daily requirement for the children in the range 4 to 8 years. With increasing the Pb soil pollution up to 1000 mg/kg soil, only 12.1% Fe requirement was supplied in this age group. The results of this experiment showed that applying enriched cow manure with iron slag has affect on increasing Fe requirement from tomato consumption. However, tomato cultivation in Pb polluted soil can decrease fruit Fe concentration and thereby, decrease the human Fe intake.

In patients with a Chronic Obstructive Pulmonary Disease(COPD) for which cure is not a realistic goal, maximizing patients’ function and well-being should be a primary objective of care. However, quality of life in COPD patients is lower than normal. Hence well examined the Effect of Educational film On Quality Of Life On Patients With Chronic Obstructive Pulmonary Disease(COPD) The present research is a semi-experimental study that conducted 0n 40 individuals in inner ward Qaen Shohada Hospital in 1395-1396 academic year. Sampling done in frequent references to inner ward of the hospital. Life quality questionnaires (Sf-36) and demographic features Before and one month after the discharge completed. Finally the data obtained from questionnaire was analyzed by means of spss software version 20 at a significant level of 0.05 based on Wilcoxone, pair T- test. 21 (52.5%) female and 19 (47.5%) were men with an average age of 62.6. The mean score of total quality of life, physical and mental dimensions, and all eight dimensions of quality of life, before and after intervention, were significantly different. (P

Memory and learning are one of the most complex brain functions and a mechanism for encoding, storing and recalling learned information. Due to the prevalence of learning disabilities, especially in older adults, the present study aimed to investigate the effect of hydroalcoholic extract of chamomile on avoidance memory levels in rats. In this experimental study, 48 adult male rats were divided into 6 groups: control, control 1 (treatment with normal saline) and control 2 (Shuttle Box) and three experimental groups receiving 200,100, and 400 mg/kg hydroalcoholic extract of chamomile by intraperitoneal injections. All of them were prescribed for 15 days. In this study, the Shuttle Box was used to measure memory and learning. The latency of entering and the time of remaining in a dark chamber of the Shuttle Box were recorded. The results were analyzed by ANOVA and Tukey tests using the SPSS-22 software. The significance level of data was considered as p≤0.05. The results showed that doses of 200 and 400 mg/kg chamomile extract significantly increased the latency of entering the dark chamber and also doses of 100, 200, and 400 mg/kg chamomile extract significantly reduced the time of remaining in the dark chamber of the Shuttle Box in the remembering phase at the level of P≤0.001 compared to the control group. The results of this study showed that chamomile extract strengthens avoidance memory in rats. This effect is probably due to flavonoids, antioxidants and phytoestrogens.

The purpose of present study was investigated of association between the prevalence of metabolic syndrome and physical activity at work, leisure time and during exercise among over 30 years old male students in Sabzevar. 200 male students over 30 years old of University of Applied Sciences in Sabzevar city randomly were selected. Components associated with the metabolic syndrome were measured. The physical activity levels of the participants in the three domains measured by "the Baecke Physical Activity questionnaire". The mean of each component of the metabolic syndrome in three BMI groups were analyzed by ANOVA and Kruskal-Wallis tests. Multinomial logistic regression analysis was used to determine the relationship between metabolic syndrome and its components with physical activity levels. weight, waist circumference, fasting blood glucose, low-density lipoprotein, cholesterol, triglyceride, prevalence of metabolic syndrome significantly were high in overweight and obese subjects than normal weight people but, total physical activity and domains significantly were low (p˂0.05). The risk of increased abdominal obesity, systolic blood pressure, diastolic blood pressure and triglyceride levels were significantly lower in active and relative active people than inactive people (p˂0.05). The chance of having a metabolic syndrome was significantly higher in inactive people during exercise than active peoples (p˂0.05). it seems that in obese and overweight Sabzevar male students the prevalence of metabolic syndrome and its components more than normal weight males. Also, Inactive people are more likely to be exposed to metabolic syndrome and some of its components than active people.

One of the most important environmental pollutants that there is in sewage of different industrials is cyanide to cause pollution of water sources that are dangerous to humans and the environment. Cyanide can be removed in different ways from the aqueous media, but most of these methods are costly. Therefore, the aim of this study is the removal cyanide using iron nanoparticles.

Removal of cyanide from aqueous media using iron nanoparticles in various conditions including the effect of the adsorbent, initial cyanide concentration, contact time and pH were studied in discontinuous phase. In this study, adsorption equilibrium and also the kinetics of the reaction examined.

In the process of sharing discontinuous, the balance was achieved after 120 minutes of contact time and maximum amount of removal cyanide in the pH =11 for cyanide concentration of 2.5 mg/L and 1 gr of nanoparticle over 97% obtained. Also the results showed that the adsorption process fitted with Langmuir isotherm and chemical kinetic fitted with of secondary grade.

According to the findings, iron nanoparticles can be used as a suitable option for removal cyanide from aqueous solution in hazardous waste. Keywords: iron nanoparticles, cyanide, hazardous waste

Sexual satisfaction is a key factor in the quality of life of individuals. Better physical state, mental health, general welfare related on the sexual satisfaction. The purpose of this study was to determine the sexual satisfaction in women referring to comprehensive health centers in Mashhad in 2017. This study was a descriptive-analytic study. The research population consisted of 300 women who referred to comprehensive health centers of Mashhad in 1396 who were selected by available sampling method. Data gathering tool was a standard Golombbog-rightist sexual satisfaction questionnaire whose validity and reliability were confirmed in previous studies. Data analysis using SPSS. 16 and descriptive and inferential statistics were performed with a significant level of 0.05 and a 95% confidence interval. According to the results of the study, there was a significant relationship between sexual satisfaction with income variables, type of home and living with whom (p-Value

Radiopharmaceuticals in nuclear medicine have several applications in medicine such as diagnostic and therapeutic.Radiopharmaceuticals with gamma emitter radionuclides are used more in diagnostics. It is due to the low absorption of gamma gamma in the tissue relative to the particles of beta and alpha. The aim of this research is calculation of effective dose distribution in human body due to injection of 99mTc-Octrotide radiopharmaceuticals (Somatostatine analogue) in mice body.Materials & Effective dose in human body is estimated using MIRD (Medical Internal Radiation dose) phantom and MCNPX for different organs. Energy of gamma source and tally type are considered 140keV and F6 respectively. Effective dose after injection of 99mTc- Octreotide is estimated by MCNPX simulation code. The adrenals and pancreas received the most effective dose relative to the other organs 6mSv/185MBq, 1.5 mSv/185MBq respectively. Discussion and The results showed that the adrenal and the pancreas are the organs of at risk in 99mTc-Octreotide radiopharmaceutical imaging.

The aim of present study was to investigate effects of endurance training on surfactant protein-D in streptozotocin–nicotinamide induced diabetic rats. In this experimental study، thirty-six adult male Wistar rats in the weight range of 200±48gr, randomly assigned in to four groups: healthy control, diabetic control, diabetic endurance training and healthy endurance training. For induction of diabetes, intraperitoneal injection of nicotinamide solution (120 mg/kg) and STZ solution (65 mg/kg) was used. The endurance training protocol was performed for 8-week and Twenty-four hours after the last training session blood serum samples were examined for evaluating reproductive hormones. Data were analyzed using one-way ANOVA and Turkey’s Post Hoc test at 0.05%. Endurance training caused a significant decrease in blood glucose in the endurance diabetic training group compared to the diabetic control group (P=0.000). Serum Protein-D Surfactant (SPD) serum levels in the diabetic control group significantly decreased (P=0.001) and the insulin resistance index (P=0.000) was significantly lower than healthy controls. 8 weeks of endurance training significantly increased in SPD (P=0.041) in endurance diabetic training group compared to diabetic control group. Also, exercise significantly decreased insulin resistance index (P=0.000) and insulin (P=0.029) in endurance diabetic training group compared to diabetic control group. It seems that Endurance training by increasing the levels of serum SPD improve insulin resistance index in type 2 diabetic mice.

Reactive oxygen species (ROS) result in serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. The aim of present study was to investigate the effect of two type sprint and endurance exercise trainings on 8-oxoguanine DNA glycosylase (OGG1) and hydroxy-2'-deoxyguanosine (8-OHdG) levels in the brain and liver of Wistar rats. 24 adult Albino Wistar rats were randomly divided into sedentary control, sprint exercise training, and endurance exercise training groups. Rats in sprint and endurance exercise training groups ran on treadmill for 6 weeks, 6 days per week, at 80 to 100 percent of maximal oxygen consumption. OGG1 and 8-OHdG levels were measured using sandwich ELISA assay. Data analyzed using one way ANOVA at P≤0.05 level. Results showed that both of sprint and endurance exercise trainings result in significant increase in OGG1 levels in brain and liver. Sprint exercise training resulted in greater increase in brain OGG1 than endurance exercise training. However, sprint and endurance exercise training had no significant effect on 8-OHdG levels in brain and liver tissues. OGG1 content correlated negatively with 8-OHdG levels. Collectively, sprint and endurance exercise trainings prevents from genomic structure through an increase in OGG1 contents.

  Anoxic-oxic (A/O) is a new method of wastewater treatment and is being used in Mahdishahr wastewater plant. considering the lack of studies in this area, it seemed necessary to study the performance of A/O system in wastewater treatment. This study was carried out to evaluate the efficiency of Mahdishahr wastewater Treatment Plant. The present cross sectional study was conducted in 2014 during 8 months. Sampling was performed two times per week from the incoming wastewater, aeration pond and effluent. Overall, 200 samples were collected. The efficiency of Treatment Plant was measured by TSS, BOD5, COD, MLSS, MLVSS, and SVI indices in aeration ponds based on standard method. Then the datas were analyzed by statistical analysis. The mean concentrations of BOD5, TSS and COD in influent were 221.6 mg/l, 203.8mg/l and 321 mg/l respectively. The mean concentrations of BOD5, TSS and COD in effluent were 23.65 mg/l, 16.79 mg/l and 34.9 mg/l respectively. According to the results the average removal efficiency of BOD5, TSS and COD were about 87.25%, 91.77% and 87.29% respectively. These results are in accordance with standards of Iranian Department of Environment to be used for agricultural purposes. During the study, the monthly mean for SVI was 67.3 ml/g and the mean for MLSS and MLVSS was 1880 and 1182 mg/l respectively.   in present study, the efficiency of A/O process in COD removals is approximately 89 percent, representing high degradability of wastewater in A/O reactor. In addition, according to the results this method was efficient and the effluent complied with Iranian standards in terms of COD, TSS and BOD5, thus the flow is suitable for reuse or discharge to water courses.

. The new methods of the teaching of cardiovascular system have been surface anatomy educate is necessary for physical examinations in clinic. . The purpose of the present study was to identify of the effectiveness surface in the anatomy education of heart auscultation. A descriptive analytical study was conducted on 34 of the medical students were into divided two group according to sex then separately instructed to the small groups 17 (n=2) the students for teaching of the surface heart auscultation. Before and after education of heart auscultation the surface anatomy, they exactly find proper exact location for heart.. The collected data were analyzed by using pair and t tests. Out of 34 students 10 were male and 24 female , the average age of the students was 21.54± 1.63 in the males whereas it was 20.56± 1.6 in the females. Mean of time to the find correct foci for mitral , tricuspid, aorta and pulmonary of heart auscultation after surface anatomy education was significantly lesser compared with the current or before applying new education method (P < 0.001). Results showed heart auscultation for mitral, pulmonary and aorta was significantly compared better when compared with the result before surface anatomy education. The results showed that teaching of the surface anatomy heart auscultation for medical students result in better finding of exact heart auscultation and decreased the time taking for finding such location.

Despite progress in health, Contamination of lice are considered as a health problem. The aim of this study was to investigate the spatial distribution of Pediculosis in the cities covered by Mashhad University of Medical Sciences in 2016. This study was descriptive and analytical cross sectional. Information from 7453 Pediculosis patients was extracted from the Sina Electronic Health Record in a 4-month period (November 2016 to March 2017). To show the spatial distribution of the disease, was used the GIS software. That was used SPSS software to analyze the data and graph pad software to plot the graphs. The study showed that 91.2% of the total population was women and 64.1% were adolescents aged between 7 and 18 years old. Prevalence rates in elementary and children under the 6 years were 42.6% and 31.8%, respectively, with the highest prevalence. Pediclusis transmission was 64.6% in schools and 46.3% in the direct transmission method. Based on spatial distribution map of Khalilabad, the highest prevalence and Kalat were the least prevalence among Khorasan Razavi counties. Considering the results of this study, it can be said that elementary girls are more likely to expose to contamination. Schools were the most probable places of contamination, and direct contact were the most common way of contamination was obtained. People with higher levels of education were less likely to be infected.

the period of pregnancy and childbirth influences the quality of psychological life and marital satisfaction in addition to physiological changes. According to the importance of effective variables on marital satisfaction, the present research studied the moderating effect of psychological well-being in relation between adaptability and family correlation with marital satisfaction among women with first parturition. it is a descriptive-correlation research. The population of the present research included all women with first parturition in June and August of 2017 in Shahidan-Movini hospital of Sabzevar (420 individuals). 198 individuals were selected by available and voluntary sampling. In order to obtain data, 18-question form of Rief's psychological well-being questionnaire (RSPWB-18) (1989), Olson family correlation and adaptability scale (1999) and Enrich marital satisfaction inventory (1989) were used. Data were analyzed by Pearson correlation coefficient and interactive multiple regression. findings of the present research showed that there are significant relationship between family correlation and marital satisfaction (p

In the last few decades, research has been focused on the use of natural products for cancer therapy, such as crude plant extracts or some of different plant secondary metabolits. The objective of this study was to examine the invitro cytotoxic activities of crude ethanolic extract of leaf and flower buds of Crataegus melanocarpa, on human MCF-7 and HeLa cell lines, with different concentrations, by Dye exclusion and Micro culture tetrazolium test (MTT) assay. The optical density (OD) colored solution was quantified at 570 nm wavelengths by an ELISA Reader, after 24, 48 and 72 h incubation. The results showed that ethanolic extracts, after 48h incubation, at in 5 and 10 mg/ml suppressed the proliferation of cancerous MCF-7 cells by significant diffrence with control group (p

Pistachio hull, a by-product of pistachio processing, is a source of environmental pollution and can cause the health problems. Therefore, it must be treated by proper, sanitary and economical manners. One of the basic parameters for compost valuation is determine the amount of heavy metals. The objective of the present study was to determiner the concentration of heavy metals (pb, Cd, cr, Zn, Ni, Cu ) in the compost produced from mixed pistachio hull and livestock and compare levels of heavy metals with the limits of international and internal standards. This study is a descriptive cross-sectional that in sampling was two-stage in September 2014 and October 2015. Among total from 2 composting pile, compound sampling based, 26 sample were selected. After digestion of the samples, the concentrations of metals (Pb ,Cd, Zn, Cr, Cu, Ni) by means of atomic absorption analysis and the concentration of a component in the sample based on mg/kg dw were reported. The results were analyzed by using Excel and SPSS software. The heavy metals examined in the composted pistachio hull mixed with livestock waste were as follows: pb as 67.09, Cr as 49.58 Cd as 2.84, Cu as 107.95, Zn as 188.24, Ni as 79.75 (mg/kg dw), respectively. Compare the average concentration of heavy metals in samples with Iran and EPA Astandrads showing concentrations of heavy metals in all samples (except metal cu) are less than the standard limit. Based on the results, compost produced from pistachio skin and livestock waste the of heavy metals hygienic standards adhered to and usability of its environmental objectives.