مجله علوم پزشکی پارس
سال شانزدهم شماره 1 (پیاپی 43، بهار 1397)

 

Alkaline phosphatase and osteocalcin are bone remodeling markers. So that, increased their level is associated with bone formation. On the other hand, continued cigarette smoke is associated with the change in bone remodeling indexes. The present study aimed to assess the effect of 3 months aerobic training on alkaline phosphatase (ALP) and osteocalcin as bone remodeling markers in smoker males.

Thirty two sedentary age-matched (42 ± 2 years of old) males’ cigarette smokers were recruited in this study by accessible sampling and were randomly divided into experimental (n = 16) and control (n = 16) groups. The experimental group performed 12 weeks of aerobic exercise (3 days per week / 60-80 % of maximum heart rate) and control subjects did not exercise training. Pre and post training of anthropometrical markers, fating serum osteocalcin and ALP were measured in 2 groups. The ANKOVA test was used to evaluate the statistical significance of the changes. The change less than 0.05 were considered significant.

Significant decreases were observed in anthropometrical markers by aerobic training in exercise group (p < 0.05). Aerobic training induced significant increase in serum osteocalcin (p = 0.011) and ALP (p = 0.019) in experimental group, but these variables did not change in control group (p > 0.05)

long term aerobic training in presence continued cigarette smoking can be improved bone formation in smoker males.

Many surgical operations require tracheal intubation for anesthetizing the patients. Intubation and extubation are usually associated with complications in patients. Reducing these complications increases surgical efficiency and also patient satisfaction with surgery. Analgesics are used to reduce these complications. Therefore, the present research was conducted to compare the effects of Lidocaine and pethidine on reducing post-extubation complications in patients referred to operating theatres in Peymaniyeh Hospital in Jahrom.

This clinical trial was carried out on 210 patients who were randomly put into the pethidine, Lidocaine, and control groups. After the surgical procedures and before removing the endotracheal tube, the first group received 20 mg of pethidine, the second group 2ml of Lidocaine, and the third group did not receive any drug. Post-extubation complications such as sore throat, coughing, nausea and vomiting, straining, laryngospasm, transient hypoxemia, and strained voice were compared. The information was analyzed using SPSS 11.5 and descriptive statistical tests (mean and percentage) and inferential statistical tests (chi-square, t-test, ANOVA, etc.)

Patients who received pethidine suffered less straining (p=0.032) and sore throat (p=0.046), but there were no significant differences between the two experimental groups in laryngospasm, transient hypoxemia, nausea and vomiting, coughing, and strained voice. The Lidocaine and the control groups did not differ significantly in post-extubation complications (p>0.05). Furthermore, a larger number of the patients in the pethidine group developed sore throat compared to the Lidocaine group (p=0.049).

Although pethidine was more effective in reducing pain than Lidocaine, yet it did not decrease many of the complications. Therefore, the best method is to concurrently use low doses of both pethidine and Lidocaine.

CYP17A1 and CYP19A2 enzymes are key proteins in constructing and regulating steroid hormones such as cortisol, testosterone and estrogen. But the effect of exercise on these two proteins in ovary tissue has not been investigated yet. The purpose of present study was investigating the effect of swimming training on CYP17A1 and CYP19A1 gene expression in ovary tissue of healthy Wistar rats.

20 two months healthy Wistar rats, mean weight of 180±20 gr were selected and divided to two groups of exercise (n=10) and control (n=10) randomly. Exercise group performed swimming five days in a week for 6 weeks. Statistical test of Mann-Whitney was used for data analysis.

CYP17A1 and CYP19 gene expression increased significantly in exercise compared to control group (P=0.05).

regarding the role of CYP17 and CYP19 in steroid hormone synthesis, probably six weeks of swimming can be an important non pharmacological intervention for treatment of ovulation and infertility problems

 

Silver nanoparticles have a wide range of aplications in medical sciences which their efects depend on their size. Synthesis of Silver nanoparticles is very valuable due to its numerous applications in detection of pathogens, cancer therapy and targeted drug delivery. The purpose of this research is to production of silver nanoparticles by using the aerial parts extract of Ferulago angulata extract and Check Antimicrobial activity of nanoparticles. Material and

To achieve this purpose, the obtained extract from Ferulago angulata Plant, was exposed to the silver nitrate solution of 0.1 molar with different concentrations for duration of 24,48, 72 and 96 hours. After changing the color to brown, by using UV-visible, DLS, SEM, TEM, XRD and FTIR analyses the existence of Nano silver particle was proved.

The UV-visible spectroscopy showed that silver nanoparticles had an absorption peak at 450 nm. By considering the results of conducted analyses, the mean diameter of particles was 19 nm and the size of particles about 3 to 62 nm and were spherical shape. Finally, the antimicrobial activity of silver nanoparticles against the Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa was investigated and proved.

The obtained results show the good functioning of this plant for the synthesis of nanoparticles clearly. So, It can be useful in the treatment of many diseases transmitted by the bacteria in the medical field

lipid profile disorders are important in children because they plays an important role in future cardiovascular atherosclerotic disorders. Lack of sufficient data in this regard in Fars province was the reason of performing this study. 500 healthy children were gathered from Kavar schools with systematic randomized method sampling. Body measurements and lipid profile were checked with standard methods. Data were analyzed by SPSS software. We find that 35% of children have at least one abnormal lipid profile tests. 34.7% had low HDL, 7% had high total cholesterol, 13.6% had high triglyceride and 10.6% had high non HDL cholesterol. Among these abnormalities, high total and high non HDL cholesterol were more prevalent in girls. The most associated factors were body weight, height and waist circumference. 35% of children have at least one abnormal lipid profile tests and cholesterol disorders were more prevalent in girls. We suggest early screening, early diagnosis and treatment of these abnormalities in children which need prevention of risk factors such as obesity and inactivity.

There are several reports on the therapeutic effects of curcuma longa in traditional medicine such as anti inflammatory, antinocieptive , antioxidant ,anti carcinogenic and hepatoprotective effects. Therefore, In this study we investigated the the analgesic effect of this Plant in experimental models of acute and chronic Pain as compare to Sodium Salicylate. Curcuma Longa extract were prepared using percolation method. Different dose of root extract (100/200/300 mg/ kg i. p ) and sodium salicylate (300 mg/kg i. P) were given. The analgesic activity was assessed in experimental models of acute pain (tail flick) and chronic pain (used formalin test).
Findings: All dose of extract and sodium salicylate had analgesic effect than control group in tail flick test& second of phase formalin test (P<0.05). It seems that Curcuma Longa induces its inhibitory effect on acute and chronic Pain

purpose of this study was to evaluate the effectiveness of AEBT therapy on reducing anxiety and experiencing avoidance of Mixed Trichotillomania، Skin picking disorder and Nail biting with three month follow up This study was a single-subject experimental design with multiple step-line based and follow-up on six patients (two patients for each disorder) with 10 sessions over the course of three month follow up، Samples were selected using purposeful method. Data was gathering through Massachusetts Hospital – Hair pulling Scale، Keuthen Skin Picking Scale، Beck Anxiety Inventory، Acceptance and Action Questionnaire and Malone- Massler Nail biting scale. The results of this study showed that Acceptance Enhanced Behavioral Therapy can reduce anxiety in patients with trichotillomania، skin picking and Nail biting، as well as experimental avoidance in patients with trichotillomania and skin picking decreased and the results were maintained during the follow-up period، but reduction of experimental avoidance in Nail biting was not significant and requires further studies on this subject

Introduction Leishmaniasis is a parasitic disease caused by a number of Leishmania species which is manifested in two forms: cutaneous (cutaneous or CL) and visceral (Kala-azar). The disease is transmitted by the bite of the infected sand flies. The present study aimed at analyzing the epidemiology of cutaneous leishmaniasis and the factors affecting it over the time period from 2012-2016 in South Khorasan Province.
Methods This cross-sectional study was conducted through a descriptive methodology. The subjects included patients diagnosed with CL and treated between 2012-2016. The collected data were statistically analyzed using SPSS v. 21.
Results The average age of the patients was 75.17 ± 89.26. Each patient had approximately 2 lesions on average, with a mean size of 59.1 ± 12.2 [mm]. About 62% of the subjects (263 people) were male. The most frequent cases were observed in 2015 and the least ones occurred during 2014, respectively. Only 3 cases were Afghan citizens while the remaining were Iranians. Patients’ residences were almost evenly distributed.
Discussion and Conclusions The results showed that there has been no decrease in the number of patients over the last few years in South Khorasan. Considering the relatively high incidence of CL in the province and its rising trend, more attention should be paid to educational programs and preventive measures.