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Diabetes and Obesity - Volume:2 Issue: 1, Spring 2010

Iranian Journal of Diabetes and Obesity
Volume:2 Issue: 1, Spring 2010

  • تاریخ انتشار: 1389/04/25
  • تعداد عناوین: 7
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  • Beman Ali Jalali Khanabadi, Hassan Mozaffari Khosravi, Mohammad AfkhamiArdekani Page 1
    : Oxidative stress is a serious complication in diabetic patients. Black tea and also sour tea contained some flavonoids with antioxidant properties and may be helpful in prevention of lipid oxidation. The aim of this study was to compare the effects of sour tea and black tea on in-vitro copper induced serum lipids oxidizability in diabetic patients.
    MATERIALS AND METHODS: In this sequential double-blind randomized controlled clinical trial, 60 diabetic patients were divided into case and control group randomly. Patients in case group used sour tea, and control subjects used black tea as the same program for 4 weeks. Fasting blood samples were taken at the beginning and end of the study for evaluation of serum lipid oxidizability. Lipid oxidation was followed by the formation of conjugated dienes, in diluted serum, after added Cu2.
    There were no significant differences in serum lipid oxidation parameters between the case and control groups.
    Keywords: Diabetic patients, Sour tea, Black tea, Serum lipid oxidizability
  • Masoud Reza Manaviat, Maryam Rashidi Page 7
    : Pseudoexfoliation syndrome (PEX) leads to some problems in the eye surgery specially cataract surgery. As the prevalence of eye problems is high in diabetic patients, we meant to assess the prevalence of PEX in diabetic patients.
    MATERIALS AND METHODS: In this cross-sectional study, 400 type 2 diabetic patients aged 50 or above who referred to Yazd Diabetes Research Center were selected consecutively in a year. Ophthalmologic examinations were performed with slit-lamp, 3-mirror lens, indirect Ophtalmoscopy and Applanation Goldman Tonometer. The criterion used to diagnose PEX was the presence of pseudoexfoliation material on one or more anterior segment structures.
    Four hundred diabetic patients aged 50 years or above were recruited for the study. Of whom 24 patients were found to have PEX with an overall prevalence of 6%. The results of this study showed that the prevalence of PEX had a direct relationship with the age of participants until the age of 70.
    In our study the prevalence of PEX was 6%. Comparing our results with similar studies in the same region in non-diabetic patients at the same age, the prevalence of PEX in diabetic patients was shown to be less than non-diabetic patients.
    Keywords: Diabetes, Pseudoexfoliation syndrome (PEX), Secondary glaucoma
  • Mohammad Afkhami Ardekani, Laleh Borgian, Javad Mohiti Ardekani, Zohreh Chiti, Maryam Rashidi, Laila Azod Page 12
    : To evaluate the relationship between serum level of testosterone and sex hormone-binding globulin in men with type 2 diabetes.
    MATERIALS AND METHODS: In this case-control study, forty men aged 40-70 with type 2 diabetes mellitus were randomly selected and compared with 40 non-diabetic men. The two groups were matched for their age and BMI. After complete observation and examination, fasting blood sugar, postprandial blood sugar, total and free testosterone, sex hormone-binding globulin and HbA1c were measured.
    The mean serum level of total testosterone was 9.65 ± 2.16 mg/dl in diabetic patients and 12.77 ± 3 mg/dl in non-diabetic subjects which was significantly different (P = 0.0001). The mean value of free serum level of testosterone was significantly higher in non-diabetic group (14.96 ± 4.97 mg/dl) in comparison with diabetic group (9.55 ± 8.14 mg/dl, P = 0.0001).
    In this study we found a lower level of total testosterone, free testosterone, and in lesser extent sex hormone-binding globulin in men with type 2 diabetes comparing to non-diabetic men.
    Keywords: Serum testosterone_Hormone_binding globulin_Type 2 diabetes
  • Mohammad Reza Rezvanfar, Bahman Salehi, Mohammad Rafiee, Faezeh Shirian Page 16
    : To evaluate the relation between major depressions and glucose control index in type 2 diabetes mellitus.
    MATERIALS AND METHODS: One- hundred thirty four patients with type 2 diabetes were enrolled in this study. Hamilton Rating Scale for Depression (HAM-D) and HbA1c were measured in patients. Linear mixed-model analysis was applied to determine the relation between HbA1c levels and depressive symptoms.
    Groups of patients with and without depression were similar in age and BMI. Correlation analysis revealed no significant relationship between HAM-D scores and HbA1c level. Depressive scores were significantly higher in diabetic patients with hypertension (P = 0.0001) and on insulin treatment (P = 0.005). There was a significant positive relationship between HAM-D scores and disease duration. (P < 0.01).
    The findings of this study showed that there was no significant association between the level of depressive symptoms and HbA1c in patients with type 2 diabetes.
    Keywords: Major Depression_Glycemic control_Type 2 diabetes_HbA1c
  • Mohammad Afkhami Ardekani, Maryam Rashidi, Ahmad Shojaoddiny Page 20
    : We aimed to evaluate association between thyroid dysfunction, and lipid profile and glycated hemoglobin in type 2 diabetic patients.
    MATERIALS AND METHODS: This cross-sectional study was carried out in type 2 diabetic patients who referred to Yazd Diabetes Research Center. A total of 1200 type 2 diabetic patients who had thyroid dysfunction according to clinical examinations and laboratory results were chosen as case group and 1200 type 2 diabetic patients who were matched with case in age, sex and duration of diabetes and had no thyroid dysfunction confirmed by clinical and laboratory examination, were chosen as control group. In this study the following variables were measured: Glycosylated hemoglobin (HbA1c), lipid profiles [Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)].
    There was a significant difference between HbA1c (8.9 ±1.99 vs. 7.1±1.02), TG (234.07 ± 88.69 vs. 205.89 ± 58.47), TC (209.56 ± 45.59 vs. 199.48 ± 41.55), LDL (125.05 ± 46.5 vs. 114.5 ± 45.42) and HDL (37.69 ± 16.78 vs. 43.79 ± 20.25) between two groups (P = 0.001). Moreover, a higher proportion of type 2 diabetic patients with thyroid dysfunction had elevated levels of TC (52.3% vs. 43.6%) (P = 0.001), LDL cholesterol (71.8% vs. 64.3%) (P = 0.001), HbA1c (83.8% vs. 35.9%) (P = 0.001) and TG (84.3% vs. 81.2%) (P = 0.02) compared with euthyroid group.
    Our findings indicate that screening of thyroid dysfunction in type 2 diabetic patients is necessary because thyroid dysfunction can produce significant metabolic disturbances.
    Keywords: Type 2 diabetes mellitus_Thyroid dysfunction_Dislipidemia_Glycosylated hemoglobin
  • Farhad Fatehi, Golnaz Malekzadeh, Atefeh Akhavimirab, Maryam Rashidi, Mohammad Afkhami Ardekani Page 27
  • Masoud Reza Manaviat, Zohreh Chiti Page 32
    : Diabetes mellitus has shown a tremendous health and social burden worldwide. Better glycemic control in patients with diabetes can be achieved by improving their knowledge which consequently will prevent developing microvascular and neurological complications. Some studies demonstrate effectiveness of Short Message Service (SMS) for patient education. Regarding exponential growth in mobile phone penetration and its text messaging service in Iran, we decided to evaluate effectiveness of sending SMS in improving knowledge of patients with type 2 diabetes in Yazd, Iran.
    In this randomized controlled trial, 100 patients with messages were sent to the mobile phones of intervention group every other day using an Internet-based messaging system for 45 days. The control group just received the diabetes were randomly allocated into Intervention Group or Control Group. Short invitation messages for taking part in the study and a free physician visit. Knowledge of patients was assessed using a questionnaire with 20 multiple choice questions.
    Eighty one patients (43 intervention group, 38 control group) concluded the study. Mean of correct answers in intervention group improved significantly (P < 0.001) from 7.92 to 11.51 after 45 days, while this difference was not significant in control group. Mean of incorrect answers decreased from 8.00 to 7.00 in intervention group, but it increased from 8.90 to 9.45 in control group. The change of mean score, before and after the intervention, was significantly different between the two groups (P < 0.001).
    SMS is an effective means of conveying information to the patients with diabetes who own a mobile phone. Further studies are suggested to check whether this improvement in knowledge will lead to change in their attitude and/or practice.
    Keywords: Diabetes, Short Message Service (SMS), Patient Education, Knowledge