Journal of Advanced Biomedical Sciences
Volume:5 Issue: 4, 2016

Hemangiopericytoma is an uncommon vascular tumor derived from the pericytes of Zimmermann. . The most common location of the tumor is pelvic retroperitoneum and musculoskeletal system of the lower extremities. It is rarely seen in the head and neck area. In addition, only 0.8% to 3% of all orbital tumors and less than 5 % of primary sinonasal tumors are primary hemangiopericytoma, which demonstrates that the orbital and sinonasal cavities are rare locations for this tumor.
Case: 2 cases of primary orbital and sinonasal hemangiopericytoma that were successfully treated through surgery were reported.
Hemangiopericytoma is an uncommon vascular tumor which has a potentially malignant behavior. Histopathologic features alone do not predict the biologic behavior of the tumor but the increased cellularity, necrosis, hemorrhage and more than 4 mitotic figures per 10 high power field, may elicit a diagnosis of malignant hemangiopericytoma . The local recurrence and the distant metastasis might also occur with an incomplete excision. The lung, bone and liver are the most common sites of distant metastasis. Thus, the long-term follow-up is recommended after the surgical removal of the tumor.

Despite widespread usage of ionizing radiation in medical diagnosis and treatment methods, development of radio-protective agents is important in modulating normal tissue damages. The inherent toxicity of synthetic compounds and the confirmation of low toxicity of natural compound in accordance with long – term usage of medicine have led many researchers to investigate the radio-protective abilities of natural compounds. Hesperidin (HES) is a flavanone glycoside, belonging to the flavonoid family found in human diet abundantly and noted for its many beneficial effects. However, hesperidin has fewer protective effects than synthetic compounds and less toxicity and possibility of oral administration. That is why it can be offered as a suitable radio-protector in radiotherapy patients, radiation workers, astronauts, and the public.

Industrial pollution including trace elements is the ability to exert many biological effects such as cancer and inflammatory diseases on humans. Therefore, in this study, some of the inflammation and cancer awareness factors such as P53 and IL6 and some blood indices are examined along with trace elements to which people are normally exposed.
The population includes 45 workers subjected to trace elements who are studied in comparison with the control group with some biochemical parameters such as WBC, RBC, and CRP. In addition, gene expressions of p53 and IL6 are measured by Real time PCR technique.
The results show that the gene expressions of IL6 and P53 increases significantly (P –Value p53=0.00, IL6=0.0037). Furthermore, the number of red and white blood cells demonstrate a substantial upsurge. The level of liver enzymes of ALT and AST grows. Additionally, ALP reduces and CRP is negative in all the subjects. (P = 0.001).
The results confirm that industrial pollution is able to induce some changes in gene expressions of P53, IL6, and some blood parameters. It may create serious risks for people who will be exposed to pollution in the future.

Prevention and control of brucellosis is necessary to identify the influential factors. Therefore, this study has aimed to investigate the effective factors in preventive behaviors of brucellosis in ranchers of Charaoymaq County.
In this cross-sectional study, 200 ranchers participated who were selected via stratified random sampling from 5 health centers. To collect information, a questionnaire was used based on health belief model. The data analysis was performed, using SPSS 21, statistical tests of linear regression analysis, and correlation and description tests at a significance level of p In this study, there was a significant correlation between education level and preventive behaviors and among the structures of health belief model. According to regression analysis of health belief model structures, the strongest predictors of behavior were tips to action, self-efficacy, and perceived susceptibility.
Based on these results, using educational models can be effective in identifying factors influencing health behaviors. The findings of this study also showed that tips to action, self-efficacy, and perceived susceptibility are the most important predictors of behavior, and special attention must be paid to designing and implementing educational interventions on them.

Nowadays, development of drug resistance against chemical antimicrobial drugs has attracted attention using medicinal plants in treatment of infections. The aim of this study is to evaluate the antimicrobial effects of two species of Centaurea plant’s essential oil on drug resistant clinical isolates of three pathogenic isolates.
The studied plants were collected from Marand city in East Azerbaijan, Iran and were confirmed as Centaurea Depressa M.B. and Centaurea Cyanus L. by botanists of Iran Agriculture Organization. The essential oil of these plants (Stems and leaf) were extracted via steam distillation method by Clevenger, and their antimicrobial effects were studied by well diffusion method in the abovementioned bacteria. The components of essential oil were identified by injection to gas chromatography linked to mass spectrometry (GC/M).
The results of this study prove that the essential oils from the abovementioned plants have bactericidal effects. The most antibacterial effect is observed in Escherichia coli strains. The results of GC/MS chromatography reveal that the essential oils of Centaurea Depressa M.B. and Centaurea Cyanus L. have 28 and 32 compounds, respectively.
This study confirmed that the grasses could be used in medicinal plants group with antibacterial properties. However, their effects in vivo must be evaluated and the most effective component of them must be identified carefully so that they can be applied commonly as an alternative synthetic drug in treating infections.

Non-alcoholic fatty liver disease, characterized by the deposition of fat in liver cells, can cause fibrosis, cirrhosis, and liver cell damage if not controlled. The aim of this study is to compare the effects of medication therapy and exercise training with diet on liver enzyme levels and liver sonography in patients with non-alcoholic fatty liver disease (NAFLD).
In this quasi-experimental study, female patients with non-alcoholic fatty liver were randomly divided into two groups: medication therapy (n = 10) and exercise therapy (n = 10) for 8 weeks. During this period, the exercise group performed exercise training three days a week for 90 minutes per session. The drug was given to the medication group. In both groups, the diet was 500 calories less than their daily energy. Before and after intervention, blood tests and liver sonography were executed. All statistical analyses were done using SPSS for Windows version 20. Comparisons between and within groups were performed by Student's t-test and Wilcoxon test on paired and unpaired data. P In both groups, liver enzyme levels and disease severity in sonography reduced significantly (p The findings of the present research showed that both methods of therapy have the same effect on reducing the severity of NAFLD.

Pseudomonas aeruginosa is a common cause of nosocomial infection. OprD protein is a specific protein regulating the uptake of carbapenem antibiotic. Loss of OprD is the main mechanism of Pseudomonas Aeruginosa resistance to carbapenem. In this study, the presence of OprD gene is investigated in isolated Pseudomonas Aeruginosa in burn patients of Ghotboddin hospital in Shiraz.
Material & 66 Pseudomonas Aeruginosa were isolated from wound specimens of 250 burn patients. Strain characteristics were confirmed by biochemical tests. Antibiogram was done via disc diffusion method. Finally, OprD gene was investigated by PCR.
Isolated Pseudomonas Aeruginosa showed more sensitivity to chloramphenicol and colicitin and more resistance to ciprofloxacin, gentamycin, cefotaxim, ceftazidin, imipenem, meropenem, and erythromycin. 61 percent of isolates were positive for OprD gene by PCR.
The findings of this study revealed that Colicitin and chloramphenicol are more effective in treatment of Pseudomonas Aeruginosa infections in burn patients, and deletion and mutation in OprD gene cause bacterium resistance to carbapenem antibiotic.

Gastric cancer is 2-4 folds higher in men than women. Sex hormones are one of the leading causes of sexual dimorphism in incidence of gastric cancer. The aim of this study is to compare Cathepsin D and Caspase-7 gene expressions in the gastric tissue of normal men and women.
In this cross-sectional study, gastric antrum tissue samples were collected from 21 healthy females and 21 males in the three age groups including 35, 35-50, and over 50 years. Following RNA extraction and cDNA synthesis, the expressions of genes were compared between men and women via semi-quantitative Reverse Transcription-PCR method. The obtained data were analyzed, using the statistical T-Test and ANOVA.
Statical analyses confirmed that the expression of Cathepsin D gene was significantly higher in men under 35 than those in the range of 35-50 years (p=0.04). In addition, the expression of Cathepsin D gene was significantly 10 folds in pre-menopause than post-menopause women and men (post-menopause women and men as one group) (p=0.008). Furthermore, the expression of Cathepsin D gene between men and women was significant at borderline (p=0.056).
The findings of the present research indicate that the expression of Cathepsin D is higher in pre-menopause than post-menopause women and men, and is greater in men under 35 than those in the range of 35-50 years.

Campylobacter can be transmitted through the raw milk. The purpose of this study was to determine the prevalence of Campylobacter genus and Campylobacter jejuni (C. jejuni) species in raw milk samples.
In this study, 72 samples of raw milk were collected of the platforms milk in the Amol city in summer. Phenotypic identification of Campylobacter genus and C. jejuni species using microbiology laboratory methods and molecular identification of this bacterium using Multiplex- Polymerase Chain Reaction (M-PCR) were performed. The data was calculated using the SPSS 16.0 software and the Fisher's exact test (p Among the 72 samples, 13.88% of samples were contaminated with C. jejuni and 2.77% were contaminated with Campylobacter genus. The highest prevalence rate for this bacterium was in July (20.83%) and the lowest prevalence rate was in September (12.5%). The significant difference between the prevalence of the Campylobacter genus and C. jejuni species in raw milk samples in various months of summer was not observed (p = 0.07).
This study showed the raw milk contamination with Campylobacter, and thereby the sanitation in the dairy food production places and the use of fast and accurate method to identify this bacterium is important.

Diabetes mellitus has different side effects on various tissues of the body. This study was conducted to determine the effect of hydroalcoholic extract of Dracocephalum kotschyi on blood glucose and lipid profile of streptozotocin-induced diabetic rats.
In this experimental study, 48 male Wistar rats (200-250 g) randomly divided into 6 equal groups. Normal control and control diabetic received distilled water, whereas the control group received the hydroalcoholic extract of Dracocephalum kotschyi (120 mg/Kg bw). Three treatment diabetic groups received 40, 80 and 120 mg/Kg bw of hydroalcoholic extract of Dracocephalum kotschyi, respectively. All rats were treated orally by gavage which continued daily for 21 days. The level of blood glucose and lipid profile was measured at the end of the study in different groups.
The Mean blood glucose in the extract treatment groups decreased significantly compared to the diabetic control. The mean of total cholesterol in the treatment groups with 80 and 120 mg/Kg bw of the extract were 105.8±9.73 and 102.73±8.75 mg/dl respectively, that reduced significantly compared to the diabetic control (135.2±12.15 mg/dl). The mean of triglyceride in the treatment groups with 80 and 120 mg/Kg bw of the extract were 177.81±13.47 and 164.86±12.53 mg/dl that reduced significantly compared to the diabetic control (206.75±17.42 mg/dl).
The extract of Dracocephalum kotschyi probably has reduced the blood glucose and lipid profile in diabetic mellitus.

The axial role of the oxidative stress in the pathophysiology of Parkinson disease has been identified. On the other hand, the learning and memory impairment in Parkinson disease has a distinguished outlook. Since Saffron has antioxidative stress effects, the aim of the present study is to investigate the improving effects of Saffron extract on the spatial memory parameters in the experimental models of Parkinson disease in male rats.
Methods & Materials: In this experimental study, 35 male rats weighing approximately 250±50 gram were randomly divided in five equal groups: control, sham (saline ascorbat), Parkinson's model (injection of 6-OHDA, 2/5 μg/ μl) and 2 groups of Parkinson's model saffron extract pretreatment (5 and 10 μg/rat for 5 days). The Parkinson’s induction model was made by intracerebral injection of 6 – hydroxy dopamine. The Morris Water maze was used for studying the spatial learning and memory. The data analysis was performed by using One-Way ANOVA.
Intracerebral injection of 6- hydroxy dopamine increased the time latency required for finding the hidden platform and damaged the spatial memory (P The Saffron extract is able to restore the spatial memory parameters such as the time latency and the distance travelled for finding the hidden platform in Parkinson's rats as compared to the level of the control group.

Klebsiella Pneumoniae is one of the most important infection bacteria of the Enterobacteriaceae family. It is also the second factor of hospital bacteremia due to the gram negative bacteria after Escherichia coli. In this research, this bacteria with the private 16SrDNA gene, was identified through PCR-ELISA technique.
In this method the dNTP labeled with Digoxigenin was used for amplifying the specific gene. Streptavidin was loaded in ELISA plate, and then the specific Biotinylated probe was used to connect the Polymerase Chain Reaction (PCR) product. Biotinylated probe was connected to the streptavidin and the amplified gene was attached to the probe. Finally, the digoxigenin antibodies were used to identify the PCR product. The reaction was measured with an ELISA reader.
16SrDNA of Klebsiella pneumoniae was amplified using the gene specific primers resulted in a fragment of the bp 260. The results of PCR-ELISA showed that this technique does not cross-react with the bacteria in their families. Additionally, the sensitivity of 6.0 ng was evaluated.
In this research, PCR-ELISA technique was known as an accurate and rapid test for the detection of infection agents by using the specific gene. PCR-ELISA can act as an alternative method instead of time-consuming, less sensitive, and expensive techniques such as culture bacteria in blood agar plates, Macconkey agar, Realtime PCR and differential biochemical tests which are currently used in the research labs.

The purpose of the current study was investigation the effectiveness of group transdiagnostic therapy on anxiety, depression, cognitive strategies of emotional regulation, and general performance in women with comorbid anxiety and depression in Ahwaz, Iran.
The population of this study was all women patients who referred to the Health Services Center of Ahwaz Oil Industry, (from December 2013 to May 2014). The sample consisted of 45 patients with comorbid anxiety and depression who were selected by simple, random sampling method and were assigned to experimental, placebo, and control groups. Prior to the intervention, the questionnaire was completed by all three groups. The experimental group received eight sessions of group therapy. The control group received no intervention, and placebo group, like the experimental group, only attended the eight sessions.
The results of MANCOVA and Benferoni post hoc showed that in the experimental group, anxiety, depression, and negative cognitive strategies of emotional regulation decreased and positive cognitive strategies of emotional regulation increased, compared with the placebo and the control groups. In addition, a significant improvement was achieved in the general performance of the experimental group; however, no noticeable differences were found between the placebo and the control groups in terms of the variables.
Group transdiagnostic therapy is effective in reducing symptoms of anxiety and depression and improving emotional regulation.

Although ionizing radiation is effective in the diagnosis of illnesses, it is dangerous from the perspective of protection for patients and radiographers working in radiology sections. Therefore, knowledge, understanding, and application of radiation protection can play an important role. The aim of this study is to assess the knowledge, attitude, and practice of the radiation protection principles in radiation workers in medical imaging centers and hospitals in Fasa, Fars, Iran.
The present study is a cross-sectional one among all 50 radiation workers employed in radiology departments of this city. A questionnaire was the means of evaluation which contained demographic information and questions about the knowledge, attitude, and practice of radiology staff regarding the radiation protection. All of the completed questionnaires were analyzed, using SPSS19 software.
Radiographers’ participation rate was 100%, and the mean score of knowledge, attitude, and practice of radiation workers in the field of radiation protection was 42.36, 62.4, and 48.54, respectively. Depending on the degree of their knowledge, there was no statistically significant difference between the radiographers’ age, gender, and work experience, and the relationship between the following factors was not substantial.
The results showed that by increasing the level of education, the awareness of radiation workers increases, too. To raise awareness of radiation protection for radiation workers, it is better to hold training courses.

Diabetes mellitus is one of the most common endocrine disorders affecting millions of people worldwide. Here, the effects of co-administration of zinc and vanadium sulfate on blood glucose levels in diabetic animals were studied. Notably, the study on the effects of the separation of zinc and vanadium has been done previously.
Moderate diabetic hyperglycemia was induced by streptozotocin (STZ) 40 mg/kg, ip injection. Five groups were selected (n=5), Group I: As normal group, during the trial did not receive any drug treatment and consumed tap water during 45 days. Group II: As control diabetic group, received STZ 40mg/kg, ip injection and consumed tap water, but they did not receive any drug treatment. The diabetic animals (STZ 40mg/kg, ip) with 500-600 mg/dl blood glucose levels were randomly divided into three groups: Group IIIAs under treatment 1, used drinkable water containing 1mg/ml of vanadium sulfate. Group IV: As under treatment 2, used drinkable water (0.25 mg/ml zinc sulfate). Group V: As under treatment 3, used drinkable water (1mg/ml of vanadium sulfate and 0.25 mg/ml zinc sulfate).
FBS remained high in group II (468±55.32mg/dl), whereas in group III vanadium reduced the FBS level to 209.2±32.29 mg/dl. In group IV zinc reduced the FBS level to 216.4±10.44 mg/dl. In group V vanadium and zinc sulfate reduced the FBS level to 139.2±92.9 mg/dl.
Zinc and vanadium sulfate separately can lower the blood sugar and their simultaneous oral administration has stronger impact on lowering the blood sugar.