فصلنامه طب مکمل
سال سوم شماره 3 (پیاپی 8، پاییز 1392)

Anxiety disorder is a common، problem that often associated with physiological symptoms. Because of synthetic drugs and medications possess enormous side effects، hence the present study was to investigate anxiolytic effect of seed of Ziziphus jujuba extract (SZJE) in rat using in Elevated plus maze (EPM). Anxiety was measured by the number of entries and duration spent in open and close arm of the EPM following administration of the extracts intraperitoneally (i. p). Total number of entries was measured as an index of locomotor activity. Diazepam (1. 0 mg/kg، i. p.) was used as the positive control. The SZJE at the dosage 50-100mg/kg increased the percentage of time-spent (p<0/05، p<0/001) and at the dosage 100mg/kg increased the percentage of arm entries in the open arms of the EPM (p<0/001) and decreased the percentage of time-spent and the percentage of arm entries in the closed arms of the EPM. The effect of The SZJE at the dosage 100mg/kg did not differ significantly from diazepam. Ad ministration of the extracts in these doses had no effect on locomotor activity. These results suggested that extract seed of Ziziphus jujuba possessed anxiolytic effect at 50-100 mg/kg doses.

A collection of physical and psychological symptoms associate with the menstrual cycle in women during childbearing age is called Premenstrual Syndrome. The aim of this study was to compare the effects of Omega-3 and Perforan on severity mood symptoms in Premenstrual Syndrome. The study was a randomized، double blind، placebo- controlled trial، with three treatment- groups. The subjects of this study (150 students) were divided randomly into three groups include of Omega-3، Perforan group and placebo control group. The subjects took drugs during three subsequent cycles so that they took two capsules daily in the first cycle for one month and in the second and third cycles they took them from eight days before menstruation to two days after it and records the severity of the symptoms of her menstruation in the questionnaire of the symptoms. The severity of premenstrual syndrome was lower in the treatment groups (Omega-3 and Perforan) than in the placebo group. Results showed that there was no statistically significant difference between three groups before the intervention (p=0. 68). But severity of mood symptoms one، two and three months after use of omega-3 were (30. 46، 32. 79 and 24. 06) and one، two and three months after use of perforn were (30. 93، 31. 80 and 23. 64 respectively (p=0. 001). Omega-3 and Perforan significantly reduce the severity mood symptoms of Premenstrual syndrome.

Premenstrual syndrome (PMS) refers to a cyclic appearance of somatic and psychiatric symptoms that affect some women. Finding an effective and safe method for the treatment of PMS has always been a serious concern. The purpose of the present study is to evaluate the effect of omega-3 fatty acids and rose damascena in the treatment of PMS. A randomized placebo controlled clinical trial was performed on 120 women. The women randomly assigned into 3 equal groups. The first group received omega-3 500 mg/day، the second group received rosa damascene 30 drops/day and third group was as control group that received placebo during leuteal phase for 3 consecutive cycles. The severity of each of the symptoms were compared in all groups before and after intervention. Statistical analysis was performed using chi-square tests، fischer exact test، and ANOVA. There were no significant differences among the groups according to age، BMI، level of education، and the severity of primary symptoms. The mean severity of affective and psychological symptoms including tension، depression fatigueability، decreased libido، lack of concentration، crying، suicidal thonghts increased appetite in rosa damascene group were significantly lower than the other groups (p=0. 001)، and the mean severity of physical symptoms including edematous extrimities، breast tenderness، bloating and palpitation in omega-3 group were significantly lower than the other groups (p=0. 001). Headache and forgetfullness have not any meaningfull difference between groups. Rosa damascena and Omega-3 seems to be effective in reducing psychiatric and somatic symptoms of PMS. Therapeutic use of these drugs needs further studies.

The Premenstrual syndrome (PMS) is a combination of distress physical، psychological and behavioral changes that occur in the luteal phase of the menstrual cycle and lead to disordering in individual relationships and normal activities. Since، the etiology of the PMS is not clear، to relief the symptoms of this syndrome، different methods were used. The main object of this project is to compare the effects of 2 different methods of aerobic exercise and vitamin B6 intake on the severity of symptoms of premenstrual syndrome in Non-Athlete girls in 2011-12. Sixty non - athlete girl students aged 18-25 at Khorasgan University were chosen 5 questionnaires and also daily symptoms the were divided into three aerobic exercise، vitamin B6 and control groups randomly. They aerobic exercise constructed for 8 weeks، 3 sessions in a week، and each session 60 minutes done in the University Club. The experimental group (vitamins B6) were used a pill every day for 2 month s. After 1 month s the PMS questionnaire was distributed among the 3 groups again (mid-test) and after 2 month s the posttest was conducted. The results showed that the severity of symptoms reduced after 1 and 2 (P ≤ 0. 001) month s exercise. Also the results indicate that the mean score in decreasing physical، psychological symptoms and total score in Aerobic was more than vitamins B6 and control group (P ≤ 0. 05). The results of this study concluded that aerobic exercise and vitamins B6 intake can reduce the severity of symptoms of premenstrual syndrome.

Dysmenorrehea is one of the most common side effects of IUD. Considering public enthusiasm to the use of herbal medicine and positive effects of cumin on muscle cramps، this study conducted to compare the effects of cumin and mefenamic acid capsules on secondary dysmenorrhea due to IUD. This crossover triple-blind randomized clnical trial study was performed on 100 IUD users who came to 6 health centers in Karaj. Research took place in three stages. In the first stage severity of dysmenorrehea was measured using Visual Analogue Scale (VAS). In the second stage all participants were randomly allocated to mefenamic acid and cumin groups. They took capsules for two consecutive cycle. In the third stage each research unit received the same treatment of the opposite group with replacing the medicine for two more consecutive cycle. Severity of pain was assessed using VAS for 5 cycle. Considering that the maximum efficacy time for cumin was 24 hours and for Mefenamic acid was 6 to 8 hours،the use of drugs in 7 days duringmenstruation،had no effect on subsequent cycles. Data، was analyse by Chi-square and Fisher''s exact test، paired t-test، Wilcoxon،and one way ANOVA. The mean pain intensity before treatment was 4. 28 ± 1. 72 and after treatment was 1. 89 ± 1. 37 and 2. 01 ± 1. 33 in the mefenamic acid and cumin groups. There was a significant difference in decrease of pain intensity in both groups (P<0. 001). There wasn’t a significant difference in decrease of pain intensity between two groups. This study showed that cumin same as mefenamic acid capsules can decrease the severity of dysmenorrehea effectively. Therefore it is recommended to use it in the treatment of secondary dysmenorrhea due to IUD.

Multiple sclerosis affects the patients’ quality of sleep. Acupressure is an inexpensive and non invasive procedure that can be used to control symptoms of the disease. The aim of this study was to investigate the effect of acupressure on quality of sleep in women with MS. In this single blind randomized clinical controlled trial، 100 women were recruited from Esfahan MS association. Subjects were equally divided into two groups of experimental and placebo، by random allocation method. Then P. S. Q. I was used to evaluate the quality of sleep in each group. The members of experimental group were under acupressure in shen men point for 5 minutes bilaterally. In addition، the participants were instructed to perform acupressure in same point once daily for four weeks. Subjects in placebo group were trained to touch the placebo point. The quality of sleep was measured in both groups four weeks after intervention. The data was analyzed by SPSS. The study findings showed no difference in sample characteristics between the experimental and placebo groups. But there were no significant differences in quality of sleep (p=0. 89) at baseline in two groups. There was significant improving on quality of sleep in experimental group compared to placebo group four weeks after intervention (p<0. 0001) This study showed، that acupressure can be effective in improving sleep quality in women with multiple sclerosis.

Nausea is the worst and prevalent complication of chemotherapy. Reduction of this is one of the most important role of oncologist nurses. The purpose of this research is to Investigate the effect of therapeutic touch on anticipatory and acute induced-nausea in breast cancer women in 2013-14 in Isfahan. This is a randomized control trial، one side blind study containing 3 research groups (control، placebo، intervention) done in Seyed Alshohda hospital in Isfahan 2013-14، the study was constructed by the use of random allocation، intervention of Therapeutic touch on breast cancer women and with same medicine regiment among the 3 groups. The data was recorded by demographic form and VAS at anticipatory and acute phase. Data analysis was done by SPSS،v16 and Sign & kruskalwallis. 41% of patients experienced anticipatory nausea. Findings show that therapeutic touch was significantly effective in reducing intensity of acute nausea compare to control and placebo groups after 24h (p<0/0001). But it was not true about anticipatory nausea. Base on findings educating and implementing of TT plane is proposed for clinical nurses to reduced chemotherapy induced acute mausea.

Recently، the herbs with medicinal effects has been subject of attention of many of researchers. The Turkmen people use roasted fruit Elaeagnus Angustifolia powder in sesame oil as home remedy for burn wounds. The aim of study was to report the use of powder fruit Elaeagnus Angustifolia on healing of burn wound. In this descriptive observational study in 2010 by purposeful sampling 40 patients from Aq-Qalla (Turkmen area in Northern Iran) whom has burn wounds degree two were included. The patients used roasted powder of fruit Elaeagnus Angustifolia in sesame oil as remedy. Data analyzed using Chi-square and t-test at significance level p<0. 05. 60 percent of the patients were male and the mean age of them was 21. 9 years. The most cases of burn was due to hot liquid and flame of fire and the most extent area of burn was 9 to 30 percent. In terms of severity، 80 percent of patients had second-degree burn. The less frequency use of Elaeagnus Angustifolia was twice and most one was six times. The recovery period varied from 7 to 14 days. The results showed the users of this traditional remedy achieved to complete recovery and also reported no infection. According to the patients self-reports and the researchers'' observations، the use of roasted powder of Elaeagnus Angustifolia in sesame oil was effective in healing of burn wounds with severity degree two. The researchers believed that merely with randomized clinical observation the effectiveness of Elaeagnus Angustifolia would be evaluated.