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nephropathology - Volume:5 Issue: 4, Oct 2016

Journal of nephropathology
Volume:5 Issue: 4, Oct 2016

  • تاریخ انتشار: 1395/07/10
  • تعداد عناوین: 7
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  • Azar Nickavar* Pages 116-117
  • Naser Mirazi *, Seyedeh, Nahid Movassagh, Mahmoud Rafieian, Kopaei Pages 118-122
    Background
    Materials can cause liver and kidney damage which carbon tetrachloride is one of these substances. Medicinal plants and their essential oils and extracts have been used to a large extent as drugs to better control and management of kidney diseases.
    Objectives
    The aim of this study was to investigate the effect of hydro-alcoholic extract of Avicennia marina leaves in the treatment of renal toxicity induced by carbontetrachloride.
    Methods
    Forty-two male rats were randomly divided into 6 groups (n = 7): control (taking normal saline, 0.5 ml/day, intraperitoneally; i.p.), sham (taking olive oil, 0.5 ml/day, i.p., single dose), injury induced by carbon tetrachloride (CCl4) 1:1 with olive oil, 0.5 ml single dose, i.p.), treated groups 1, 2 and 3: by carbon tetrachloride 1:1 with olive oil, 0.5 ml single dose and 200 mg/kg, 400 mg/kg or 800 mg/kg Avicennia marina extract (AME)/ day for 96 hours, i.p.). By direct blood sampling from the heart, the plasma concentrations of lactate dehydrogenase, blood urea nitrogen (BUN), creatinine and liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were measured. Kidney sections were prepared from all groups and the histological examinations were performed. The results were analyzed using one-way analysis of variance (ANOVA).
    Results
    The results indicated the significant (P
    Conclusions
    Carbon tetrachloride has kidney, liver and cardiac toxicities and mangrove extract is able to inhibit the toxicities of carbon tetrachloride.
    Keywords: Mangrove, Avicennia marina, Kidney, Carbon tetrachloride
  • Sadrollah Mehrabi*, Eslam Askarpour, Farhad Mehrabi, Ramin Jannesar Pages 123-127
    Background
    Nasturtium officinale is a traditional herb that is used for diuresis.
    Objectives
    The aim of this study is to determine the effects of hydrophilic extract of Nasturtium officinale on ethylene glycol-induced renal stone in male Wistar rats.
    Materials And Methods
    In this study 32 male Wistar rats were randomly divided in six groups and studied during 30 days. Two groups of negative and healthy control received 1% ethylene glycol in water respectively. Low and high dose preventive groups, in addition to 1% ethylene glycol, daily gavaged with 750 mg/kg and 1.5 g/kg of extract respectively. All rats were hold in metabolic cages individually in days 0, 15 and 30 and 24-hour urine samples were collected and checked for urinary parameters of stone formation. In 30th day, rats were anesthetized with ether, and after taking serum sample from them, were sacrificed and their kidneys were sent for pathological evaluation and for presence and volume of calcium oxalate crystals.
    Results
    Percentage of calcium oxalate crystals in negative control groups (75%), preventive groups with low dose (28.6%) and high dose (57.1%) in comparison to healthy control group (12.5%) increased (P
    Conclusions
    This research showed that the Nasturtium officinale extract has no significant effects in urinary and chemical parameters efficient in calcium oxalate stone crystals in rat but its extract in low dose has some preventive effect on renal stone formation.
    Keywords: Nasturtium officinale, Calcium oxalate, Ethylene glycol, Nephrolithiasis
  • Akram Ahangarpour, Ali Akbar Oroojan*, Layasadat Khorsandi, Razieh Shabani, Shahnaz Mojaddami Pages 128-133
    Background
    Diabetic nephropathy is defined as a progressive decline in glomerular filtration rate, accompanied by proteinuria. Betulinic acid (BA) employs in the treatment and management of diabetes.
    Objectives
    This study was designed to evaluate the preventive effects of BA on streptozotocinnicotinamide (STZ-NA) induced diabetic nephropathy in male mouse.
    Materials And Methods
    In this experimental study, 60 adult male NMRI mice (20-25 g) were obtained. Type 2 diabetes induced by intraperitoneal (IP) injection of a single dose of STZ (65 mg/kg) 15 minutes after an IP administration of NA (120 mg/kg). Then, mice were divided into six groups; control, diabetes, diabetes BA (10, 20 and 40 mg/kg), and diabetes metformin (200 mg/kg). Twenty-four hours after the last drug administrations, plasma samples were obtained and maintained at −20°C for albumin, blood urea nitrogen (BUN) and creatinine (Cr) measurements. Renal tissue was removed, fixed in 10% formalin solution and stained with hematoxylin and eosin.
    Results
    Plasma albumin level decreased in diabetic mice (P
    Conclusion
    BA has a preventing effect on diabetic nephropathy by amelioration of plasma albumin, BUN, Cr and renal histology changes during diabetic situation.
    Keywords: Betulinic acid, Diabetic nephropathy, Metformin, Diabetes mellitus
  • Davood Arab, Arash Ardestani Zadeh*, Majid Mirmohammadkhani, Azadeh Beiglarzadeh Pages 134-138
    Background
    Prostate-specific antigen (PSA) is a serine protease that is secreted by prostate cells and it is useful as a tumor marker for prostate cancer.
    Objectives
    In this study, the relationship between some of metabolic factors and serum PSA level was investigated.
    Patients and
    Methods
    In this cross-sectional study, patients with urinary symptoms or for screening of the prostate cancer (after 50 years of age or 40 years with a family history of prostate cancer), were evaluated. Collected data included metabolic syndrome factors such as cholesterol (Chol), triglycerides (TG), fasting blood sugar (FBS), and body mass index (BMI), serum PSA level, prostate volume and age.
    Results
    481 patients were enrolled to this study with the average age of 60.69 ± 9.72 years and the average PSA level of 1.70 ng/ml. Data analysis showed that there was a significant relationship between serum PSA level with age (P
    Conclusions
    This study showed that, with increasing age and prostate volume, serum PSA level increased, and an increase in the levels of cholesterol, TG, FBS and BMI did not have significant effect on serum PSA level.
    Keywords: Prostate, specific antigen, Triglycerides, Cholesterol, Fasting blood sugar, Body mass index
  • Mahmoud Mirhoseini *, Nasrin Saleh, Ali Momeni, Fatemeh Deris, Majid Asadi, Samani Pages 139-143
    Background
    Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association.
    Objectives
    This study investigated association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes referring specialty clinic of Shahrekord.
    Patients and
    Methods
    This descriptive, cross-sectional study was conducted on 102 type 2 diabetes patients with dermopathy referring clinic constantly or as outpatient. Dermatological and ophthalmological examinations and examination for nephropathywere done for all patients. Demographic data and results of examinations and patients history, and biochemical tests were gathered and recorded by researcher developed checklists.
    Results
    Mean age of patients was 83.8 2.60 years, of whom 64 (63.7%) were female and 37.3% were male. Prevalence of retinopathy in patients was 4.31% and nephropathy3.33%. In this study, significant associations of diabetic dermopathy with diabetic nephropathy (P = 0.001), with retinopathy (P 0.05).
    Conclusions
    Results of this study confirm the association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes. Since dermopathy is usually developed before retinopathy and nephropathy, dermopathy could be used as a clinical finding in early diagnosis and prevention of retinopathy and nephropathy in diabetes patients.
    Keywords: Type 2 diabetes_Dermopathy_Retinopathy_Nephropathy
  • Azar Nickavar* Pages 144-145