فهرست مطالب

Multidisciplinary Cancer Investigation - Volume:1 Issue: 4, Oct 2017

Multidisciplinary Cancer Investigation
Volume:1 Issue: 4, Oct 2017

  • تاریخ انتشار: 1396/09/26
  • تعداد عناوین: 5
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  • Maryam Jafari *, Asieh Olfatbakhsh, Kiara Rezaei-Kalantari Pages 1-6
    While male breast cancer (MBC) consists only 1% of all breast cancers in the United States, approximately 2000 men are diagnosed annually and the incidence seems to be slowly increasing. About 50% of men have axillary nodal metastasis at the time of diagnosis. A mean delay of 6 to 10 months occurs in the diagnosis of MBC, which leads to the progression of the disease before presentation. More than 40% of MBCs presen with stage III/IV disease. Therefore, men with MBC have a worse prognosis compared with women. Additionally, as a result of the paucity of breast tissue in males, early chest wall spread occurs. Therefore, it seems that recognition of the symptoms and radiologic features of MBC can improve early detection, the prognosis and survival rate of the disease. A few researches focused on male breast cancer; however, there are many similarities with female breast cancer and some differences. The current study aimed to review the latest information on risk factors, clinical, and radiological features of MBC.
    Keywords: Breast Neoplasms, Male, Mammography, Ultrasonography
  • Hasan Jalaeikhoo, Mohsen Rajaeinejad, Manoutchehr Keyhani, Mohammad Zokaasadi, Morteza Sharifzadeh* Pages 7-11
    Introduction
    Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its effect in regard to the type of treatment was not studied so far. The current study aimed at investigating the effect of uninvolved immunoglobulins suppression on the outcome of patients with myeloma in each individual type of treatment.
    Methods
    In the current retrospective study, 140 myeloma cases diagnosed from 1999 to 2016 were studied. Patients were divided into 2 groups according to the first-line chemotherapy: 58 cases treated with Velcade-based and 81 cases with other agents. In the 2 groups, the effects of immunoglobulin suppression as well as other prognostic parameters on overall survival (OS) and progression-free survival (PFS) were evaluated.
    Results
    The effect of immunoglobulin suppression on patients’ outcome depended on the type of treatment. In the Velcade group, suppression of at least 2 classes of immunoglobulins was significantly related to poorer survival in terms of both OS and PFS. In the non-velcade group, suppression of immunoglobulins showed no significant relationship with OS or PFS.
    Conclusions
    For cases treated with Velcade, suppression of 2 types of immunoglobulins was related to poorer outcomes. Based on the results of the current study, it seemsed that immunoglobulin suppression was a predictive factor rather than a prognostic one. More studies with a larger sample size should be conducted to assess the outcome of patients treated with Velcade and severely suppressed immunoglobulins.
    Keywords: Immunoglobulin, Multiple Myeloma, Bortezomib
  • Akram Sajadian *, Mahsa Rajilahiji, Akram Motaharinasab, Anooshirvan Kazemnejad, Shahpar Haghighat Pages 12-16
    Introduction
    Breast cancer is a tragic experience that accompanies stressful situations for patients. Adjustment with breast cancer has a significant effect on decreasing stress and increasing the patient's quality of life.
    Methods
    In a prospective cross-sectional study, breast cancer patients› experiences were evaluated at Breast Cancer Research Center (BCRC), Motamed Cancer Institut (MCI), Tehran, Iran. To evaluate coping strategies in breast cancer patients, a modified Ways of Coping-cancer Version (WOC-CA) questionnaire was used. A written informed consent was obtained from the patients.
    Results
    From a total of 187 breast cancer patients participated in this study, 177 cases followed up for 6 months later. The mean age of the patients was 47. 3 ± 9. 6 years. Eighty-seven percent of the patients were married, 91% of the subjects had middle and high education and most of them (83%) were housewife. Seven coping strategies were used by the patients after diagnosis and 6 months later. The most commonly used coping strategies after diagnosis included «seeking for social support», «spirituality», and «positive cognitive restructuring» and the least used coping strategy was «detachment». The most frequently used strategies 6 month after the diagnosis were «seeking for social support», «spirituality», «positive cognitive restructuring», and «making changes» and the least commonly used ones included «wishful thinking», and «keeping feelings to self-coping strategies».
    Conclusions
    It seems that clinicians should provide enough information about the treatment and survival before the surgery. The patients concerns about the way of adjustment with the disease, especially religious thinking and advices about the way of coping with breast cancer should be considered.
    Keywords: Spirituality, Breast Neoplasms, Iran
  • Fatemeh Kianinodeh, Mahdi Tabatabaei Seyed *, Atena Alibakhshi, Mahshid Gohari, Kaveh Tari Pages 17-23
    Introduction
    Breast cancer is one of the most common malignancies among Iranian women. Nowadays, the use of traditional medicinal plants has emerged as a tempting complementary to the treatment of breast cancer due to minimal side effects and less documented drug resistance. The aim of this study was to examine the anticancer effects of the essential oils of red clover and mature fruit of Bassia scoparia on MCF-7 cells.
    Methods
    Essential oils were extracted from Bassia scoparia and red clover plants, by a Clevenger condenser and mass spectrometry was performed for qualitative analysis, then MCF-7 and HU02 cells were treated with different concentrations of these essential oils at different time intervals. The viability of cells was measured by the MTT assay. The results were analyzed using the one-way ANOVA and Tukey′s test.
    Results
    Essential oils of Kochia scoparia and red clover have cytotoxic effects on MCF7 cells. The MTT analysis showed decreased cell viability percentage in treated cells (P
    Conclusions
    The findings of this study show that essential oils of Bassia scoparia and red clover have toxic and anticancer effects on MCF-7 cells.
    Keywords: Bassia Scoparia, Red Clover, Cell Viability
  • Homa Dokht Ghanbarzadeh, Mojtaba Mohaddes Seyed * Pages 24-28
    Introduction
    Gastric cancer is the fourth common cancer and the second leading cause of death from cancer worldwide. Omega fatty acids are a group of non-saturated fatty acids of long chains derive from linolenic, linoleic and oleic fatty acids. The current study aimed at examining the possible effects of oral administration of omega-3, -6 and -9 fatty acids on gastric cancer cell apoptosis in patients with gastric adenocarcinoma via the evaluation of BCL2 gene and protein expression.
    Methods
    In the present case-control study, a total of 34 patients with gastric cancer referring to the Endoscopy Clinic at Tabriz University of Medical Sciences were selected and divided into 2 groups (n = 17). In group 1, patients were treated by platinum drugs without any supplementation and in group 2, patients were treated by platinum drugs supplemented with omega-3, -6 and -9 fatty acids over 3 courses, which each lasted 3 weeks. After stomach biopsy, RNA extraction, cDNA synthesis and real-time polymerase chain reaction (RT-PCR) were performed.
    Results
    The results showed that Bcl-2 gene and BCL2 protein expression in patients who received omega-3, -6 and -9 fatty acids with chemotherapy was lower than those of the ones who not received omega fatty acids. Also, there was a significant decrease in Bcl-2 gene expression (P
    Conclusions
    The oral administration of omega-3, -6 and -9 fatty acids with the chemotherapeutic drug cis-platinum in patients with gastric adenocarcinoma could decrease Bcl-2 gene expression and BCL2 protein production in the cancerous gastric tissue.
    Keywords: Fatty Acids, Apoptosis, Stomach Neoplasms, Drug Resistance