Clinical Features of Children With Henoch-Schonlein Purpura Risk Factors Associated With Renal Involvement

This study aimed to evaluate renal involvement and factors affecting the prognosis in patients with Henoch-Schonlein purpura (HSP). The outcomes of 107 children diagnosed with HSP who had been followed up for at least 6 months were reviewed. Renal involvement was observed in 26. 1% of the patients. The mean age of the patients with renal involvement was 8. 8 ± 4. 0 years as compared to 7. 1 ± 2. 9 years in the patients without renal involvement (P =. 02). The risk of renal involvement was found to be significantly higher in the patients who were 10 years old and over (P <. 001). In the group with renal involvement، the frequency of scrotal involvement was significantly higher than that of the group without renal involvement (P =. 02). The mean serum immunoglobulin A level of the patients with renal involvements was significantly higher (P =. 04) and the mean serum complement C3 levels was significantly lower (P =. 04) than those of the patients without renal involvement. None of the patients with renal involvement reached end-stage kidney failure. No significant relationship was observed between the development of renal involvement and early steroid treatment. This study proposes that in old children with HSP، elevated serum immunoglobulin A levels، decreased serum complement C3 levels، and scrotal involvement are associated with renal involvement. We failed to find any effect of steroid treatment on development of renal involvement.