Roger's Syndrome and Report of 3 Cases in Children

An uncommon form of children diabetes is Roger’s syndrome that characterized with Diabetes Mellitus, Megaloblastic Anemia, and sensory neural hearing loss. We described three children with this syndrome from consanguineous Iranian families (2 sibling and 1 cousin). They referred to pediatric ward of Imam Reza Hospital for hyperglycemia, anemia and sensory neural hearing loss. Molecular genetics study revealed novel mutation in SLC19A2 gene. Then we started thiamin and after therapy anemia reversed in all patients and normoglycemia achieved in two of patients but hearing loss persisted Diagnosis of TRMA should be considered in diabetic patients with hearing loss, anemia. Early diagnosis and therapy can ameliorates the diabetes and anemia and also hearing loss.