Lipoprotein (a): More than a bystander in the etiology of hypertension? A study on essential hypertensive patients not yet on treatment

Hypertension (HTN), is a very common disorder with a substantial impact on public health because of its complications.. Little is known about the association of serum lipoprotein(a)[Lp(a)] elevation with essential hypertension(eHTN)..Patients and This study was conducted on a group of essential hypertensive patients. Laboratory exams consisting of serum creatinine and Lp(a) was measured.. 95 essential hypertensive patients was enrolled to the study. Serum Lp(a) in patients was 46.5±20. In patients an inverse correlation between seum Lp(a) with creatinine clearance was seen (r = -0.175 p<0.05).Significant correlation of serum Lp(a) with age (r =0.191 p<0.05) and also a significant correlation of serum Lp(a) with duration of HTN(known duration of hypertension period) (r =0.362 p<0.05) were found.. Our data suggest that Lp(a) may be involved as a cofactor in essential hypertension, with a mechanism that remains to be elucidated..