The acute effect of celecoxib administration on inflammation and oxidative stress following intensive aerobic exercise

The purpose of this study was to examine the effect of acute celecoxib administration on exercise-induced inflammation and lipid peroxidation markers. Twenty untrained, healthy male (age; 25.5±4.5 yr, weight; 72.8±7.9 kg, height; 177.3± 7.2 cm) were randomly assigned to treatment (T) and placebo (P) groups. Blood samples were taken before, immediately, 3h and 24h after exercise. Subjects ran for 30 minutes with 75% VO2max on treadmill and 100 mg celecoxib and placebo administrated immediately and 12h after the second blood sampling to T and P groups respectively. White blood cells (WBC) and creatine kinas (CK) were measured by an autoanalyzer and malondealdehyde (MDA) by HPLC. Data were analyzed using repeated measures analysis of variance (ANOVA) with bonferoni correction and unpaired t-test. WBC levels were significantly increased 3h and decreased 24h after exercise in both groups (P≤0.05), while there was no difference between the two groups, though WBC levels were lower 24h after exercise in the T group than P group. CK levels were significantly increased immediately, 3h and 24h after exercise in both groups (P≤0.05), but there was no difference between the two groups, though CK levels were increased 24h after exercise in the T group than P group. MDA levels were significantly increased immediately after exercise in both groups (P≤0.05) but there was no difference between the two groups, though MDA levels were increased 24h after exercise in T group than P group. Acute celecoxib administration could not affect inflammation and oxidative stress