Gender Difference in the Serum Levels of Total Nitric Oxide Metabolites, Nitrite, and Nitrate in Cisplatin-induced Nephrotoxicity in Rats
Author(s):
Abstract:
Background
Nephrotoxicity is the most common adverse effect of cisplatin therapy in clinic، which also disturbs the nitric oxide system. Cisplatin-induced nephrotoxicity may be gender-related; nevertheless، no information has been well documented regarding the gender-specific influences of cisplatin on nitric oxide metabolites. In order to narrow this gap، this study was designed to determine the gender difference in the serum levels of total nitric oxide metabolites (NOx)، nitrite، and nitrate in cisplatin-induced nephrotoxicity in rats. Methods
25 male and female rats were randomly divided into 4 groups. The male groups 1 and 3 were received saline (control) and a single dose of cisplatin (7 mg/kg)، respectively. The female groups 2 and 4 also received similar treatments. One week later، the blood samples were obtained and the animals were sacrificed for pathological investigation. Findings
The serum levels of NOx (group 1 = 22. 43 ± 3 mmole/liter، group 3 = 50. 71 ± 7. 52، P < 0. 05)، and nitrite (group 1 = 13. 2 ± 2. 1 mmole/liter، group 3 = 37. 7 ± 4، P < 0. 05) in male animals treated with cisplatin was significantly higher than the control group. Such finding was not seen in female rats. The intensity of kidney tissue damage in male rats was also more marked compared with the female animals. Conclusion
The effect of cisplatin on nitric oxide metabolites could be gender related، and nitrite is more influenced by cisplatin than nitrate. More studies may be needed for clarifying the exact mechanisms.Keywords:
Cisplatin , Adverse effects , Nitric oxide , Sex , Rats
Language:
Persian
Published:
Journal Of Isfahan Medical School, Volume:30 Issue: 214, 2013
Pages:
1967 to 1975
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