Comparison of single dose and three-day course of cefixime in the treatment of women with uncomplicated acute cystitis referred to health care center in Tehran

The aim of this study was to compare the efficacy of single dose and three days course of cefiximein in the treatment of women with uncomplicated acute cystitis. This clinical trial was done on 70 women with uncomplicated acute cystitis referred to urologic and gynecologic clinic at Bou Ali hospital in Tehran (Iran), which were randomly divided into two groups. The first group (group A) was prescribed one 800 mg dose of cefixime and the 2nd group (group B) was treated with 400mg/day cefixime for 3 days. After one week & 2week of taking the prescribed antibiotics, urine culture was analyzed. Patients with resistant urine culture to cefixime (3 in group A and 2 in group B) were excluded from the study. Data were analyzed using t-test, chi- square and exact Fisher test using SPSS-16 software. The mean (± standard deviation) age of subjects was 29.97 ± 5.65. Seventeen subjects in group A and 21 in group B were married. All subjects, excluding six (1 in group A and 5 in group B), were completely cured. However, recoveries in group A were more than group B, but there was no statistically significant difference. Single 800 mg dose of cefixime is as effective as dose of 400 mg/day for 3days in treatment of women with uncomplicated acute cystitis.