Submandibular Metastatic Melanoma with unknown origin. A Case Report

The origin of metastatic Melanoma is unknown in approximately 5-10% of the patients. Various suggestions have been made for the primary origin of this lesion. In this article، a rare case of metastatic Melanoma is reported in submandibular area.

A 20 year-old woman was referred with a cystic lump in the submandibular area. She reported a pigmented macule on her lip that was completely regressed at the time of clinical evaluation. Excisional biopsy showed the lesion to be Metastatic Melanoma. The diagnosis was confirmed by Immuno-histochemcial staining for HMB45 and S100 markers. The patient is reported to be free of disease in four-year follow up based on the clinical as well as Para clinical evaluation.

Total excision of the solitary lesion is suggested in patients with metastatic Melanoma with unknown origin and regression of the primary lesion.