CD4+ and CD8+ T cells subsets in patients with allergic rhinitis in comparison to healthy people

Allergic rhinitis (AR) is a common disease in which IgE and T cells have an important role. This study aimed at comparing the frequency of peripheral T cell sublype in patients with allergic rhinitis (AR) and in healthy people. In this experimental case-control study، a total of 30 patients with allergic rhinitis and 30 healthy controls were evaluated for immunologic parameters. The students of Jundishapur University of Medical Sciences، residented in Golestan dormitory were participated in this case-control study. The mean of age ranges of students were 22. 5 ± 3. 3 years. Peripheral blood samples were collected from the students and stained with appropriate monoclonal antibodies. Percentage CD4+T cells، CD8+T cells and the proportion of CD4/CD8 were determined using flow cytometriy technique. In this study haematological methods including standard CBC test were also performed on all blood samples. The data were analyzed and compared statistically in two groups using SPSS software and t test. Mean percentage of CD4+ T lymphocytes increased significantly in case group in comparison with healthy control group (P<0. 05). However، no significant difference was seen in two groups for mean percentage of CD8+ T cells and CD4/CD8 ratio (P>0. 05). The results of CBC test showed the percentage of eosinophils and monocytes were significantly different among two groups (P<0. 05). This study provides evidence that a higher frequency of CD4+T cells is present in the peripheral blood of AR patients and it has probably a role in pathogenesis of the disease. Further investigations require to elucidate the role of CD4+T cells in pathogenesis and treatment of AR.