Prostate specific antigen staining intensity in prostatic adenocarcinoma correlates with serum prostate specific antigen, Bandar Abbas, Iran
Author(s):
Abstract:
Introduction
Prostatic adenocarcinoma is one the most common malignances and the second cause of death in males due to cancer. Prostate Specific Antigen (PZSA) serum level is the first marker to screen such patients. We aimed in this study، to assess the intensity of prostatic adenocarcinoma tissue staining with PSA staining method. Methods
In this corss-sectional study، prostatic adenocarcinoma patients referred to pathology department of Shahid Mohammadi hospital، Bandar Abbas، during 2009-2010، were investigated. The samples were first stained with H&E staining. If adenocarcinoma was confirmed then PSA staining with IHC method was carried put. Normal prostate tissue and negative control with non granular tissue and non-grander tissue were considered as positive and negative controls، respectively. Collected data was analyzed with SPSS 16، using descriptive methods and Chi-square test. Results
Mean age of the patients was 73. 63±10. 70، varying from 54 to 91 years. Grade of the tumors varied from 2 to 10، where the most frequent grade was 7. Results showed that as the degree of PSA staining decreased، serum PSA level increased (P=0. 017). Conclusion
Results demonstrated that the intensity of PSA staining with IHC has a reverse correlation with serum PSA level، whereas higher gleasons grading associated with increased PSA serum levels.Keywords:
Language:
Persian
Published:
Hormozgan Medical Journal, Volume:16 Issue: 5, 2012
Pages:
349 to 354
magiran.com/p1134559
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!