Assessing Preventive Effect of Volume Expansion in Contrast Induced Nephropathy in Patients Undergoing Cardiac Catheterization

Contrast-induced nephropathy (CIN) is most commonly defined as acute renal failure due to radiographic contrast medium exposure in patients undergoing cardiac cathetrization. In this study we investigated the possible association between volume expansions with N/S in prevention of contrast induced nephropathy. In this clinical trial study 962 patients، allocated in two groups underwent cardiac catheterization، in the first group with 575 patients، we used Normal Saline (N/S) (1-2 cc/kg/hr) but in the second group 387 patients did not use normal saline. We measured serum creatinin before and after Intervention and used T test and Man-Whitney test to analyze data. Mean Age of patients in the first group was 57. 8±10. 5 and in the second group was 57±10. 2 years، (p: 0. 212). Before catheterization Cr in the first group was 0. 94±0. 26 mg/dl and in the second group was 0. 98±0. 26mg/dl (p: 0. 04) that was a meaningful difference. After catheterization in the second group Cr was 1. 07±0. 26 mg/dl and in the first group was 1. 03±0. 30 mg/dl (p: 017) that was not a meaningful difference. Before and after catheterization serum Cr level difference in the first group was 0. 043±0. 44 and in the second group was 0. 132±0. 22 (p≤0. 01) that was meaningful. Based on this study we suggested that hydration with normal saline did not have a significant protective effect in renal performance، and it depends on gender and risk factors.