The response of homocysteine and insulin resistance to a single circuit resistance exercise in overweight women

Homocysteine and insulin resistance are two cardiovascular risk factors and the levels of homocysteine can be decreased by insulin and increased by insulin resistance states. The purpose of this research was to determine the homocysteine serum levels and insulin resistance and to investigate the relationship between them after a single circuit resistance exercise in overweight women. Participants of this clinical trial study were inactive women between 30-40 years old who were randomly divided into experimental group (n=12) and control group (n=9). Exercise protocol included 9 exercises with intensity of 40% of participants 1RM. After 12 hours overnight fast, blood levels of homocysteine, insulin and glucose were measured 30 minutes before and immediately after the exercise. Dependent t-test was used to compare the results of pretest and post tests. Indeperdent t-test was used to compare the results between the groups. Pearson correlation coefficient was used to evaluate the relationship between homocysteine and insulin resistance. The analysis of data showed a significant increase in levels of homocysteine and glucose and insulin of serum, and insulin resistance after training in the experimental group (P<0.05). These changes were significant compared with control group. The results of correlation coefficient didn`t show significant relationship between homocysteine and insulin resistance. According to the results obtain from one session circuit resistance which increased the levels of Homocysteine and insulin resistance in serum in overweight women, these exercises might probably increase the risk of cardiovascular disease in long time