CORRELATION BETWEEN EMBRYO IMPLANTION AND FOLLICULAR FLUID SELECTED CYTOKINES AND HORMONE LEVELS IN WOMEN UNDER TREATMENT BY MICROINJECTION TECHNIQUE

Concentrations of certain substances in follicular fluid (FF) may related to fertilization outcome. The study aim was to identify FF markers with which to predict embryo implantation potential. Concentrations of selected hormones، cytokines and growth factors in FF samples obtained during assisted reproduction treatment، Intracytoplasmic Sperm Injection (ICSI) method were related with treatment outcomes. Mean concentrations of 17beta-estradiol (E2)، prolactin (PRL) and insulin-like growth factor (IGF) -I were significantly higher، in treatment attempts leading to a clinical pregnancy as compared with those in which no pregnancy was established. LH، growth hormone (GH)، progesterone، and interleukin-1 (IL-1) concentrations are similar in successful and unsuccessful attempts. Fertilization outcomes were related to FF levels of PRL، E2 and IGF-I. But LH، growth GH، progesterone، and IL-1 are not markers of success.