Effect of different physical activity intensities on hematopoietic stem cells CD34+ and relationship with some of cardiovascular risk factors in women

The purpose of this study was to determine the effect of two different intensities of exercise on hematopoietic stem cells and relationship with some of cardiovascular risk factors in women.

Fourteen female students from a group volunteers (group 1: mean age 22 ±2 years, BMI 20.81±1.91 kg.m2, n = 7. group 2: mean age 21 ±2 years, BMI 20.38 ± 1.66 kg/m2, n = 7) were randomly selected via questionnaire and each group ran 30 minutes at their (60-75% of Vo2max) on treadmill. Blood samples were taken from all subjects for measurement of hematopoietic stem cells CD34+ and same Isotype control ratio LDL/HDL and Ch/HDL and triglyceride before and 10 minutes after the test. The related t-test (paired) were used for comparisons within a group. To compare variables between the groups were used multivariate analysis of variance test (MANOVA). For determining the relationship between variables Pearson correlation coefficient were used. Statistical significance was accepted as P<0.05.

Results of this study showed that both intensities of exercise increased significantly the number of CD34+ cells, this effect was higher in intensity of 75% VO2max, but was not statistically significant. No significant correlation between CD34+ and ratio LDL/HDL and Ch/HDL and triglyceride was observed.

according to the findings the present study can be expressed that physical activity with intensity 60% and 75% VO2max can increase re-enthotelialisation due to mobilization of CD34+ cells.