Acute phase response and antioxidant capacity - Effect of endurance training and detraining in rats
The aim of this study was to examine the acute phase response and total antioxidant capacity following 8 weeks endurance training and 4 weeks detraining and relationship between mentioned markers in rats. Fortyeight rats 3 months were divided randomly into control and experimental groups with age. The experimental training programs were carried out for 8 weeks with five days a week at speed of 15 to 22 meter per minute and duration of 25 to 64 minute. Then, the detraining protocol was performed for 4 weeks. Blood samples were drawn after the 8 weeks endurance training and 4 weeks detraining and after 12 hours overnight fasting. The total antioxidant capacity (TAC) and! 1 antitrypsin were measured by FRAP and Nephlometric methods, respectively. Data was analyzed using ANOVA with repeated measure, independent t-student and pearson correlation coefficient tests at P$ 0.05 level. The results showed the treadmill endurance exercise significantly increased TAC concentrations (P= 0.000) and significantly decrease! 1 antitrypsin concentrations (P= 0.000) compared with age-matched controls. On the other hand, 4 weeks of detraining lead to decrease and increase significant in total antioxidant capacity (P= 0.003) and! 1 antitrypsin (P= 0.002) levels, respectively. Also, significant negative correlation was found between total antioxidant capacity and! 1 antitrypsin. These findings suggest endurance training with moderate intensity and traininginduced adaptations can improved the antioxidant capacity and inflammation and prevents thrombus process and cardiovascular disease. According to these results, long-term endurance training caused an adaptation in inflammatory responses, which may be related to the oxidant/antioxidant balance changes favoring the antioxidants. Furthermore, detraining can reverse endurance training-induced effect in markers related to acute phase.
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