The effect of 12 weeks of interval aerobic exercise on endothelin-1 concentration of plasma in adult Sprague-Dawley rats

endothelin is vasoconstrictors which are released from endothelium. The aim of the present study was to investigate the effect of alternative aerobic exercise on the endothelin-1 concentration of plasma as an important indicator of increasing cardiovascular diseases specially hypertension in Sprague-Dawley rats. Subjects of this study were 20 adult male Sprague-Dawley rats with the average weight of 250±4 g and age 20±2 months which were kept in the temperature of 25±1 ° C، the humidity level of 20%، with the light cycle of 12 hours illumination، and 12 hours of darkness. Rats were randomly assigned to two groups of experimental (10 rats) and control (10 rats). The subjects of the experimental group participated in a selected interval aerobic exercises for 12 weeks. The results of this study revealed that 12 weeks of alternative aerobic exercises has a significant effect on decreasing endothelin-1 concentration of plasma (p=0. 001)، while no significant change was observed in control group (p=0. 24)، endotheline-1 fluctuations were fignificantly different between exercise and control goup (p=0. 022). so interval aerobic exercise can be effective in prevention of hypertension or other kinds of cardiovascular diseases through influencing on endothelin-1.