Effect of green tea catechins on PTZ-induced seizure in male mice

Epilepsy is the second most common neurological disorder after stroke. Medicinal herbs containing alternative natural drug and different properties are suitable for designing new drugs to treat epilepsy. The purpose of this study was to examine the effect of intraperitoneal injection of green tea catechins on pentylenetetrazol (PTZ) -induced seizure in male mice.

In this study، 48 NMRI male mice (6 groups of 8 mice each) received different doses of catechin (25، 50، 100،150 & 200 mg/kg) and normal saline (control). After 30 minutes of treatment، all animals were injected PTZ (80 mg/kg، i. p) to induce seizure. Then the seizure onset and the duration of the seizure phases were measured and recorded in the experimental and control groups.

The results of this study showed that some concentrations (100،150 & 200 mg/kg) of catechins delayed the onset (threshold) and stages (1، 2، 3، 4 and 5) of PTZ-induced seizures compared with the control group (P<0. 001).

It seems that an intraperitoneal injection of green tea catechins can delay the seizure onset in different stages of seizure.