Effect of two different intensity of physical activity on circulating endothelial progenitor cells (EPC) in healthy young women

The purpose of this study was to determine the effect of two different intensities of physical activity on circulating endothelial progenitor cells (EPC) in healthy young women. For this purpose, 15 female students from volunteers were randomly selected via questionnaire (group 1: mean age 22 ±1/8 years, BMI 20/81±1/91 kg/m2, n = 8. group 2: mean age 21 ±1/5 years, BMI 20/38 ± 1/66 kg/m2, n = 7). Each group ran 30 minutes at their particular (group 1: 70% HRmax & group 2: 85% HRmax) activity on treadmill. Blood samples were taken from all subjects for measurement of circulating endothelial progenitor cells CD34+ and same Isotype control, white blood cells and platelets before and10minutes after the test. The related T-test (paired) were used for comparisons within a group, to compare variables between groups were used one way of variance analysis (ANOVA) for determining the relationship between variables were used Pearson correlation coefficient. Statistical significance was accepted as a P value of <0.05. Results of this study showed that both intensities of physical activity increased significantly the number of EPC, WBC and Plt, this affects was higher in intensity 85% HRmax, but was not statistically significant. Just was observed significant association between EPC and platelet. In summary, can be expressed that physical activity with intensity 70% and 85% HRmax can increase re-enthotelialisation due to mobilization of EPC, and with attention to significant association between EPC and platelet these cell mobilization may serve as a physiologic repair or compensation mechanism in acute inflammatory injury.