The Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency

Abstract Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates. This study was conducted in Ekbatan hospitals of Hamadan (2009) on 15 favism patients and 60 non-favism ones matched by sex and age. Using Beutler method، the reduced Glutathione (GSH) level of red blood cells was measured. Based on the results، the amount of erythrocyte GSH in favism patients was 14. 99±4. 62 mg/dl and that of controls was 58. 2±10. 59 mg/dl. the results show that the erythrocyte GSH in favism patients is significantly lower than that of non-favism subjects; therefore، the former seems more likely to be afflicted by hemolytic crises owing to the use of oxidant stuff.