The Effect of a 12 -Week Endurance Training on IL-6, IL-10 and Nesfatin -1 Plasma Level of Obese Male Rats

Exercise Training has been shown to decrease chronic low- grade systemic inflammation in high- fat diet induced obesity. However، the mechanisms mediating its beneficial effects are not fully understood. Therefore، the aim of this study was to investigate the effects of a 12- week endurance training on IL-6، IL-10 and nesfatin -1 in obese male rats. Sixteen male wistar rats (2 months old) were fed a high fat diet for 8 weeks، reaching an average weight of 319 ± 30g. The animals were randomly divided into control (n=8) and 12-week endurance training (T، n=8) groups. Training group was given exercise on motor- driven treadmill at 25 to 30 m/min (0% grade)، 60 min/day، 5 days/week for 12 weeks، and both groups were given “ad libitum”. The Elisa method was used for laboratory analysis of Nesfatin-1، IL-6 and IL-10. The results revealed that the average weight of rats in T group was significantly lower than that of the control group (P=0. 001). A significant decrease was also observed in IL-6 T group (P=0. 04). Nesfatin – 1 plasma level increased in T group (P=0. 001). Despite the fact that IL-10 was lower in T group، the difference was not significant. The results of present study showed that long- term endurance training led to an increase in the anti- inflammatory nesfatin -1، and nesfatin- 1 probably plays a role in energy balance، that is independent of the changes of IL-10 and IL-6 in plasma level.