Effect of black mulberry (Morus nigra L.) consumption on serum concentrations of lipoproteins, Apo-A1, Apo-B and hs-CRP and blood pressure in dyslipidemic patients

Cardiovascular disease is a leading cause of death in most countries. Dyslipidemia is a modifiable risk factor for this disease; evidence suggests that adding bioactive compounds to the diet can positively affect heart health risk factors. The present study investigated the effect of black mulberry (Persian mulberry) consumption on serum concentration of lipoproteins، Apo-A1، Apo-B، hs-CRP، and blood pressure in dyslipidemic patients. This randomized clinical trial randomly divided 72 patients with lipid disorders that were referred to the Social Security and Bu-Ali Sina clinics in the city of Qazvin into two groups. Individuals in the intervention group consumed 300 g black mulberry juice with pulp daily for 8 wk and the control group continued their usual diet without consuming the juice. At the beginning and end of intervention، fasting blood samples were taken from both groups and serum concentrations of lipoprotein، Apo-A1 and Apo-B، hs-CRP were measured. Blood pressure was measured before and after the study using a mercury manometer. After intervention، Apo-A1 and HDL levels increased significantly and Apo B and hs-CRP levels decreased significantly over the baseline of the intervention group. The means of changes in Apo-A1 and HDL and the ratio of Apo-B/Apo-A1 were significant between the two groups. There was a significant difference between the mean values of hs-CRP of the two groups at the end of the study. Systolic blood pressure decreased significantly from baseline to the end of the study in the intervention group، but there was no significant difference between the mean systolic blood pressure of the two groups at the end of the study. There was no significant effect for other lipid parameters or diastolic blood pressure in the intervention group or between the two groups. Black mulberry consumption by patients with lipid disorders can affect heart health risk factors such as apolipoprotein concentration، blood pressure، and inflammatory markers.