TREATMENT OF CORTICAL BRAIN ISCHEMIA WITH USAGE OF ASCORBIC ACID AND AGONIST OF ADENOSINE RECEPTOR (A1)

Today stroke is a leading cause of death in the world. Early treatment can reduce the complications of the disease. The aim of this study was to examine the effect of A1 receptor agonists and Neuroprotective effects of ascorbic acid on brain ischemia. This study was done on temporal lobe of the brain and performed on eight groups of mice. Ischemia was induced by ligation of common carotid artery and after the induction inflammation ischemic area (for a week) medications were given via intraperitoneal injection. Ascorbic acid was injected one week prior to the ischemic in order to evaluate its preventive effect. After completion of the treatment، the brains were removed and fixed specimens were prepared for histological studies. Nissl staining showed more cells necrotic in the ischemic ones. Tunnel tests showed apoptotic cells in the treatment group is far less than the control group. Concurrent treatment of CPA and vitamin C significantly reduced neuronal death in temporal lobe. This study showed that the use of vitamin C and A1 receptor agonist particularly concurrent treatment of these can significantly reduce the damage caused by ischemia، in temporal lobe.