The Effect of Nettle Extract and Mefenamic Acid in Reducing the Symptoms of Menorrhagia Patients by JointModeling

Menorrhagia is considered as one of the most common gynecological problems in childbearing age of women. Regarding the prevalence of this disease، the study examinesthe effect of Nettle extract in Menorrhagia improvementby statistical modeling. Thestatistical modeling has been performed by data on 100 patients with menorrhagia. 100 patients were randomly assigned to two groups - intervention group (Nettle and Mefenamic acid) and control group (placebo and Mefenamic acid) – with equal size of 50. In this study، joint longitudinal and generalized linear model were used for predicting the probability of recovery of women who participated in the study. Joint modeling with common random effects was performed by controlling variables such as age، body mass index to assess the impact of nettle extract on improving Menorrhagia patient. Based on results the average number of menstrual days in the third month (second cycles after intervention) were (5. 52 ± 1. 44) and (6. 19 ± 1. 82) respectively in Nettle and extract groups. The difference between the two groups was statistically significant (p =0. 023). The chance of improvement who are in Nettle group were 1. 5 times control group، but there was no significant difference of improvement between the two groups (p=0. 347). In general، joint model were more accurate than the conventional models. Probability of improvement was higher in the intervention group than the control group. Using Nettle extract in reducing the number of days of menstrual cycle in patients with menorrhagia has had a positive impact.