The Effects of Helicobacter Pylori Eradication in Blood Level of Biochemical Parameters Related to Coronary Heart Diseases

Backgrounds and Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection worldwide and its possible role in diseases out of digestive systems such as atherosclerotic and peripheral vascular disorders is controversial. The aim of this study was to investigate the effect of eradication of H. pylori infection on serum lipid profile، serum levels of CRP and fibrinogen. In a before and after clinical trial، 114 patients with H. pylori infection during the last 12 months were selected. Serum level of total cholesterol، HDL، LDL، triglyceride C Reactive Protein (CRP) and fibrinogen were measured. After a six weeks period of conventional treatment، measurement of these tests were repeated. A total of 73 patients، 34 males and 39 females with a mean age of 32 ± 10 (19 to 63) years. The mean serum total cholesterol، HDL، LDL، fibrinogen was respectively 259، 110، 289، 49. 6 and 180. 5 mg per deciliter and CRP 90 mg per liter after treatment، respectively، 266، 112، 305، 52. 2 and 181. 1 mg per deciliter and CRP 50 mg per liters. The mean CRP decreased after eradication (p<0. 001). There were no significant changes in most parameters. Mean HDL increased both in men and mean fibrinogen levels decreased in≤ 40 years group. Eradication of H. pylori might be effective in reducing the risk of coronary artery disease. Gender and age are two important factors involved in this field.