Interactive effect of exercise training with ω-3 supplementation on resting levels of TNF-α and IL-10 in Karat Men

Perform heavy exercise training، causing a variety of changes including a reduction in performance. Few human studies have been examined of supplemental ω-3 and exercise، then the aim of this study the interactive effect of exercise and ω-3 on resting levels of TNF-α and IL-10 in elite Karate and compared with untrained. In this quasi-experimental 42 healthy young male elite karate and non-athletes، were randomly divided into study groups. Athletes: 1- ω -3 and exercise، 2- placebo and exercise،3- exercise and non-athletes: 1- ω -3، 2- placebo،3- control. Athletes groups performed Pre-season practice in 65% to 80% VO2 max. Consumption ω -3was 1800mg/day for 4 weeks. Blood sampling done 48 hours before، 12 hours fasting after protocol. TNF-α and IL-10 were measured by ELISA and LDL، HDL Enzymatic methods. Mean level was (P≤0. 05). Exercise training with ω-3 for 4 weeks do not have a significant effect on resting levels of IL-10، TNF- α، HDL و LDL (P>0. 05). Then ω-3 do not have a significant effect in non-athletes (P>0. 05). The results showed that Although the consumption of ω-3 do not significant changes in TNF-α and IL-10، but can was slightly reduced in TNF-α and increase in the that IL-10، that is confirming its positive effects on inflammatory factors. However، more research seems necessary in this context